Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics
Punyawee Dulyayangkul,
Thomas Beavis,
Winnie WY Lee
et al.
Abstract:Amikacin and piperacillin/tazobactam are frequent antibiotic choices to treat bloodstream infection, which is commonly fatal and most often caused by bacteria from the familyEnterobacterales. Here we show that two gene cassettes located side-by-side in and ancestral integron similar to In37have been “harvested” by insertion sequence IS26as a transposon that is already globally disseminated among theEnterobacterales. This transposon encodes the enzymes AAC(6’)-Ib-cr and OXA-1, reported, respectively, as amikaci… Show more
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