Harnessing the Antibacterial Properties of Fluoridated Chitosan Polymers against Oral Biofilms

Rahayu, Dien Puji; Draheim, Roger Russell; Lalatsa, Aikaterini; Roldo, Marta

doi:10.3390/pharmaceutics14030488

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…The use of injectable or hand-moldable hydrogels should be a clinically practical approach [1,2], especially in structurally complex tissue defects such as osteoarthritis and periodontal pockets [7,10]. Although topical antibiotics are an ideal way to treat infections, effectively reducing drug doses and achieving adequate concentrations in areas of bacterial infection, the challenges posed by drug resistance remains unresolved [43,44]. In this study, different ratios of mucoadhesive methacrylated chitosan and bioactive gelatin were prepared, after which three phenolic compounds (TA, GA, and PG) were added to the hybrid hydrogel.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications

et al. 2023

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The thermoresponsive drug-loaded hydrogels have attracted widespread interest in the field of medical applications due to their ease of delivery to structurally complex tissue defects. However, drug-resistant infections remain a challenge, which has prompted the development of new non-antibiotic hydrogels. To this end, we prepared chitosan-methacrylate (CTSMA)/gelatin (GEL) thermoresponsive hydrogels and added natural phenolic compounds, including tannic acid, gallic acid, and pyrogallol, to improve the efficacy of hydrogels. This hybrid hydrogel imparted initial crosslinking at physiological temperature, followed by photocuring to further provide a mechanically robust structure. Rheological analysis, tensile strength, antibacterial activity against E. coli, S. aureus, P. gingivalis, and S. mutans, and L929 cytotoxicity were evaluated. The experimental results showed that the hybrid hydrogel with CTSMA/GEL ratio of 5/1 and tannic acid additive had a promising gelation temperature of about 37 °C. The presence of phenolic compounds not only significantly (p < 0.05) enhanced cell viability, but also increased the tensile strength of CTSMA/GEL hybrid hydrogels. Moreover, the hydrogel containing tannic acid revealed potent antibacterial efficacy against four microorganisms. It was concluded that the hybrid hydrogel containing tannic acid could be a potential composite material for medical applications.

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Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications

et al. 2023

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“…Fluorinated chitosan has a comparable effect to sodium fluoride but contains less fluoride ions, suggesting that it can reduce the dosage of fluoride required for treatment. It also has higher antibacterial activity and very low cytotoxicity (Rahayu et al, 2022).…”

Section: Biomimetic Mineralization Effect Of Chitosan 41 Chitosan's G...mentioning

confidence: 99%

Chitosan as a biomaterial for the prevention and treatment of dental caries: antibacterial effect, biomimetic mineralization, and drug delivery

Qu,

Ma,

et al. 2023

Front. Bioeng. Biotechnol.

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Dental caries is a chronic, progressive disease caused by plaque, influenced by multiple factors and can damage the hard tissues of the teeth. In severe cases, it can also lead to the onset and development of other oral diseases, seriously affecting patients’ quality of life. The creation of effective biomaterials for the prevention and treatment of dental caries has become one of the relentless goals of many researchers, with a focus on inhibiting the production of cariogenic plaque and retaining beneficial bacteria, guiding and promoting the reconstruction of dental hard tissues, and delaying the progression of existing caries. Chitosan is a natural cationic polymer extracted from the shells of crustaceans and shellfish. Since its discovery, chitosan has shown to have various biological functions such as antibacterial, biomimetic mineralization, drug delivery, etc., making it one of the most promising biopolymers for new caries prevention and materials of prostheses. Therefore, this article provides an overview of the anti-caries applications of chitosan, which mainly covers the basic research on the application of chitosan in caries prevention and treatment since 2010, with a focus on categorizing and summarizing the following characteristics of chitosan as a caries prevention material, including its antibacterial effect, biomimetic mineralization effect and delivery ability of caries prevention drugs and vaccines. It also explores the limitations of current research on chitosan as a caries prevention biomaterial and the difficulties that need to be focused on and overcome in the future to provide theoretical reference for the clinical implementation of chitosan as a caries prevention biomaterial.

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Enhancing the antibacterial effect of chitosan to combat orthopaedic implant-associated infections

Rahayu

Mori

Yusuf

et al. 2022

Carbohydrate Polymers

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Harnessing the Antibacterial Properties of Fluoridated Chitosan Polymers against Oral Biofilms

Cited by 5 publications

References 51 publications

Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications

Synergistic Effect of Thermoresponsive and Photocuring Methacrylated Chitosan-Based Hybrid Hydrogels for Medical Applications

Chitosan as a biomaterial for the prevention and treatment of dental caries: antibacterial effect, biomimetic mineralization, and drug delivery

Enhancing the antibacterial effect of chitosan to combat orthopaedic implant-associated infections

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