“…In addition, the P6 site tends to be an allosteric one since classical downstream proteins bound here do not interact with AT 2 R [8] , [79] , [80] . Hence, regulators targeting P6 may show greater selectivity and less toxicity as the common advantage for allosteric modulators [81] , [82] , [83] , [84] , [85] , [86] . Notably, the result of virtual screening are shown for possible ligand binding mode for P6 but their bioactivity was not confirmed by experiments.…”