Harmonic acoustics for dynamic and selective particle manipulation

Yang, Shujie; Tian, Zhenhua; Wang, Zeyu; Rufo, Joseph; Li, Peng; John, D.; Xia, Jianping; Bachman, Hunter; Huang, Po‐Hsun; Wu, Mengxi; Chen, Chuyi; Lee, Luke P.; Huang, Tony Jun

doi:10.1038/s41563-022-01210-8

Cited by 101 publications

(69 citation statements)

References 40 publications

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“…However, in previous studies, the E-E mode was often used to generate a pure SSAW in the microchannel placed on the substrate of a SAW device, where frequency or phase control of the IDTs had been employed to change the positions of the standing wave nodes and thus the particles or cells captured by the nodes could be manipulated. [49][50][51] However, these situations are different from the major objective and the key driving principle of the research reported herein.…”

Section: Introductionmentioning

confidence: 85%

Droplet transportation by adjusting the temporal phase shift of surface acoustic waves in the exciter–exciter mode

Sui

Dong

et al. 2022

Lab Chip

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Section: Introductionmentioning

confidence: 85%

Droplet transportation by adjusting the temporal phase shift of surface acoustic waves in the exciter–exciter mode

Sui

Dong

et al. 2022

Lab Chip

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“…The device created a wide range of measurable force-generating behaviors by simulating various tissue conditions. For the cell phenotyping study, Yang et al [ 44 ] presented harmonic acoustics for noncontact, dynamic, selective (HANDS) particle manipulation by applying time-effective Fourier synthesized harmonics for the control of particles. They used the platform to quantify cell–cell adhesion forces among various cancer cell lines and found that the adhesion strength is decreased as the metastatic potential is increased.…”

Section: Microfluidic Devices In Cancer Researchmentioning

confidence: 99%

Applications of Microfluidics and Organ-on-a-Chip in Cancer Research

et al. 2022

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Taking the life of nearly 10 million people annually, cancer has become one of the major causes of mortality worldwide and a hot topic for researchers to find innovative approaches to demystify the disease and drug development. Having its root lying in microelectronics, microfluidics seems to hold great potential to explore our limited knowledge in the field of oncology. It offers numerous advantages such as a low sample volume, minimal cost, parallelization, and portability and has been advanced in the field of molecular biology and chemical synthesis. The platform has been proved to be valuable in cancer research, especially for diagnostics and prognosis purposes and has been successfully employed in recent years. Organ-on-a-chip, a biomimetic microfluidic platform, simulating the complexity of a human organ, has emerged as a breakthrough in cancer research as it provides a dynamic platform to simulate tumor growth and progression in a chip. This paper aims at giving an overview of microfluidics and organ-on-a-chip technology incorporating their historical development, physics of fluid flow and application in oncology. The current applications of microfluidics and organ-on-a-chip in the field of cancer research have been copiously discussed integrating the major application areas such as the isolation of CTCs, studying the cancer cell phenotype as well as metastasis, replicating TME in organ-on-a-chip and drug development. This technology’s significance and limitations are also addressed, giving readers a comprehensive picture of the ability of the microfluidic platform to advance the field of oncology.

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“…[36][37][38][39] Ultrasound shows great promise as a method to wirelessly navigate micro/ nanorobotics. [40][41][42][43][44][45][46][47][48][49][50][51][52] Specially, MBs filled with gas are excellent for focusing ultrasound, and in response to ultrasound, MBs typically form aggregations. [53][54][55][56][57][58] Dayton et al demonstrated the use of acoustic radiation forces to trap groups of MBs when they were exposed to a flow field.…”

Section: Introductionmentioning

confidence: 99%

“…[ 36–39 ] Ultrasound shows great promise as a method to wirelessly navigate micro/nanorobotics. [ 40–52 ] Specially, MBs filled with gas are excellent for focusing ultrasound, and in response to ultrasound, MBs typically form aggregations. [ 53–58 ] Dayton et al.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Controlled Swarmbots Under Physiological Flow Conditions

Fonseca

Kohler

Ahmed

2022

Adv Materials Inter

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Navigation of microrobots in living vasculatures is essential in realizing targeted drug delivery and advancing non‐invasive surgeries. Acoustically‐controlled “swarmbots” are developed based on the self‐assembly of clinically‐approved microbubbles (MBs). Ultrasound is noninvasive, penetrates deeply into the human body, and is well‐developed in clinical settings. This propulsion strategy relies on two forces: the primary radiation force and the secondary Bjerknes force. Upon ultrasound activation, the MBs self‐assemble into microswarms, which migrate toward and anchor at the containing vessel's wall. A second transducer, which produces an acoustic field parallel to the channel, propels the swarms along the wall. Noting that human arteries have a blood flow 5–19 cm s−1, powerful features of cross‐ and upstream swarmbot navigation are demonstrated against physiologically‐relevant flow rates that reach 16.7 cm s−1. Additionally, controlled navigation of swarmbots is shown within mice blood and under pulsatile flow conditions of 100 beats per minute (bpm); an adult human heart at rest executes between 60 and 100 bpm. This capability represents a much‐needed pathway for advancing preclinical research.

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Harmonic acoustics for dynamic and selective particle manipulation

Cited by 101 publications

References 40 publications

Droplet transportation by adjusting the temporal phase shift of surface acoustic waves in the exciter–exciter mode

Droplet transportation by adjusting the temporal phase shift of surface acoustic waves in the exciter–exciter mode

Applications of Microfluidics and Organ-on-a-Chip in Cancer Research

Ultrasound‐Controlled Swarmbots Under Physiological Flow Conditions

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