A detailed assessment of the macroscopic and microstructural cyclic deformation behavior of Haynes 188" has been conducted under various isothermal and thermomechanical conditions over the temperature range 26 to 1000°C.A fully reversed mechanical strain range of 0.8% was examined with constant mechanical strain rates of 109s-' and 104s-'. Particular attention was given to the effects of dynamic strain aging (DSA) on the stress-strain response. Detailed transmission electron microscopy was conducted to examine the deformation substructures and establish correlations with the cyclic macroscopic behaviors. Although DSA was found to occur over a wide temperature range between approximately 300 and 700°C the microstructural characteristics and deformation mechanisms responsible for DSA varied considerably and were dependent upon temperature. In general, the operation of DSA processes led to a maximum of the cyclic stress amplitude at -65O"C, and was accompanied by pronounced planar slip, the generation of stacking faults and high dislocation density. DSA was evidenced through a combination of phenomena, including serrated yielding, an inverse dependence of maximum cyclic hardening with strain rate (6), and an instantaneous inverse 8 sensitivity.The TMF cyclic hardening behavior exhibited unique behaviors in comparison to the isothermal response, predominantly at the minimum TMF temperature extremes.