Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Ajjemami, Maria; Ouatou, Sanaa; Charoute, Hicham; Fakiri, Malika; Rhaissi, Houria; Benrahma, Houda; Rafiey, Hassan; Barakat, Abdelhamid

doi:10.1186/s40200-015-0160-3

Cited by 14 publications

(28 citation statements)

References 43 publications

(48 reference statements)

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“…The patients carried -1131 T > C SNP was associated with increased TG level, waist circumference, fasted glucose and reduced HDL levels. These data confirmed the association of -1131 T > C variants with the predisposition to metabolic syndrome [ 50 ].…”

Section: Apoa5 Gene Polymorphisms On Obesity and The Metabolic Syndrosupporting

confidence: 84%

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

Kong

Peng

2018

Lipids Health Dis

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Apolipoprotein A5 (apoA5) has been identified to play an important role in lipid metabolism, specifically in triglyceride (TG) and TG-rich lipoproteins (TRLs) metabolism. Numerous evidence has demonstrated for an association between apoA5 and the increased risk of obesity and metabolic syndrome, but the mechanism remains to be fully elucidated. Recently, several studies verified that apoA5 could significantly reduce plasma TG level by stimulating lipoprotein lipase (LPL) activity, and the intracellular role of apoA5 has also been proved since apoA5 is associated with cytoplasmic lipid droplets (LDs) and affects intrahepatic TG accumulation. Furthermore, since adipocytes provide the largest storage depot for TG and play a crucial role in the development of obesity, we could infer that apoA5 also acts as a novel regulator to modulate TG storage in adipocytes. In this review, we focus on the association of gene and protein of apoA5 with obesity and metabolic syndrome, and provide new insights into the physiological role of apoA5 in humans, giving a potential therapeutic target for obesity and associated disorders.

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Section: Apoa5 Gene Polymorphisms On Obesity and The Metabolic Syndrosupporting

confidence: 84%

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

Kong

Peng

2018

Lipids Health Dis

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“…We found that the -1131T>C polymorphism was significantly associated with MetS. This association has been previously reported among some European, Asian, and African populations [12,[24][25][26][27][28][29][30]. The -1131C allele has also been shown as a risk factor for MetS among obese adolescents [30].…”

Section: Discussionsupporting

confidence: 85%

“…A haplotype consisting of the −1131C, c.56C, c553G, and c.1259T alleles has been shown to be associated with the MetS in Morracan patients [29]. Additionally, a haplotype which contains the minor alleles of -1131T>C, IVS3+476G>A, and c.1259T>C was shown to be higher in patients with hypertriglyceridemia than the control subjects [34].…”

Section: Discussionmentioning

confidence: 94%

Association of Apolipoprotein A-V Gene Polymorphisms and Lipid Metabolism in Mongolian Patients with Metabolic Syndrome

Chuluun-Erdene,

Dagdan,

Sengeragchaa

et al. 2017

Cent. Asian j. Med. Sci.

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Objectives: Our study determined the genetic effect of Apolipoprotein A-V (APOA5) gene polymorphisms on lipid parameters in patients with metabolic syndrome (MetS). Methods: 160 patients with MetS and 144 healthy individuals were selected for the case and control groups, respectively. APOA5 gene polymorphisms (-1131T>C, IVS3+476G>A, c.1177C>T, c.1259T>C) were genotyped using PCR-RFLP. Results: Serum levels of total cholesterol and triglyceride were higher in the MetS group than the control group (p=0.028, p<0.001), while high density lipoprotein levels was lower in the MetS group than the control group (p=0.048). The -1131C allele frequency was higher in the MetS group than the control group (p=0.048). Results of regression analysis showed that APOA5−1131C carriers had increased incidences of MetS (OR=1.87, p=0.010). The frequency of the haplotype C-A-T-C was higher in the MetS group than the control group (p=0.027). In the MetS group, the triglyceride level was significantly higher in the minor allele carriers of -1131T>C, IVS3+476G>A, c.1177C>T. Conclusion: Our results suggest that, among the APOA5 SNPs, the C allele of -1131T>C polymorphism is a risk factor for MetS.

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“…In our previous study, we reported the association of APOA5 variants (rs651821 and rs3135506) with MetS and its traits [19]. Other studies reported the involvement of rs662799 (−1131T>C) in MetS [15,20,21].…”

Section: Introductionmentioning

confidence: 85%

Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

et al. 2020

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Apoliprotein protein A5 (APOA5) has been linked to metabolic syndrome (MetS) in several populations. In North Africa, only the Tunisian and Moroccan populations were investigated. Our aim is to assess the association between APOA5 gene variant (rs662799) and haplotypes with MetS in Tunisian population and to perform a meta-analysis in North Africa. A total of 594 Tunisian participants were genotyped for polymorphism rs662799 using KASPar technology. Two polymorphisms rs3135506 and rs651821 in APOA5 gene genotyped in our previous study, were used in addition to rs662799 to assess the haplotype association with MetS. The genotype of 875 participants was used for the meta-analysis. Statistical analyses were performed with R software. The rs662799 increases the risk of MetS under the dominant (p= 0.018) and the additive models (p= 0.028) in the Tunisian population. After stratification of the cohort following the sex and the geographic origin, a positive association of rs662799 with MetS was found for participant from the Northern region and for the women group. Only the haplotype AGT showed a significant association with MetS by decreasing the risk of the disease.The meta-analysis reported a significant association of rs662799 and rs3135506 with MetS.Our results showed a significant association between the APOA5 gene variants rs662799 and haplotypes with MetS and its traits in Tunisia. An impact of the sex and the geographic origin on the genotype distribution was highlighted. Our funding emphasizes the role of APOA5 in the development of MetS in North Africa.

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Haplotype analysis of the Apolipoprotein A5 gene in Moroccan patients with the metabolic syndrome

Cited by 14 publications

References 43 publications

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

New insights into apolipoprotein A5 in controlling lipoprotein metabolism in obesity and the metabolic syndrome patients

Association of Apolipoprotein A-V Gene Polymorphisms and Lipid Metabolism in Mongolian Patients with Metabolic Syndrome

Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

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