Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror

Yang, Hao; Xi, Lei; Samuelson, Sean R.; Xie, Huikai; Yang, Lily; Jiang, Huabei

doi:10.1364/boe.4.000427

Cited by 41 publications

(29 citation statements)

References 23 publications

(21 reference statements)

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“…In fact, such control occurs naturally with MEMS devices driven by linear signals, since the MEMS device's forces follow Hooke's law of springs [44]. In Fig 3 II(c) the non-uniform and blurred measurements result in a banded matrix with varying band-width.…”

Section: B Directional Control Of Tof Sensingmentioning

confidence: 99%

Directionally Controlled Time-of-Flight Ranging for Mobile Sensing Platforms

Tasneem

Wang

Xie

et al. 2018

Robotics: Science and Systems XIV

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Abstract-Scanning time-of-flight (TOF) sensors obtain depth measurements by directing modulated light beams across a scene. We demonstrate that control of the directional scanning patterns can enable novel algorithms and applications. Our analysis occurs entirely in the angular domain and consists of two ideas. First, we show how to exploit the angular support of the light beam to improve reconstruction results. Second, we describe how to control the light beam direction in a way that maximizes a well-known information theoretic measure. Using these two ideas, we demonstrate novel applications such as adaptive TOF sensing, LIDAR zoom, LIDAR edge sensing for gradient-based reconstruction and energy efficient LIDAR scanning. Our contributions can apply equally to sensors using mechanical, optoelectronic or MEMS-based approaches to modulate the light beam, and we show results here on a MEMS mirror-based LIDAR system. In short, we describe new adaptive directionally controlled TOF sensing algorithms which can impact mobile sensing platforms such as robots, wearable devices and IoT nodes. Creating TOF sensors for personal drones, VR/AR glasses, IoT nodes and other miniature platforms would require transcending the energy constraints due to limited battery capacity. Recent work has addressed some aspects of TOF energy efficiency with novel illumination encodings. For example, by synchronizing illumination patterns to match sensor exposures [1], low-power reconstruction can occur for scenes with significant ambient light. Additionally, spatio-temporal encodings have been shown to be efficient for both structured light illumination [30] and TOF illumination as well [29]. I. INTRODUCTIONIn this paper, we demonstrate new efficiencies that are possible with angular control of a TOF sensor. We demonstrate this with a single LIDAR beam reflected off a microelectromechanical (MEMS) mirror. The voltages that control the MEMS actuators allow analog (continuous) TOF sensing angles. As a modulator, MEMS mirrors have well-known advantages of high-speed and fast response to control [32].

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Section: B Directional Control Of Tof Sensingmentioning

confidence: 99%

Directionally Controlled Time-of-Flight Ranging for Mobile Sensing Platforms

Tasneem

Wang

Xie

et al. 2018

Robotics: Science and Systems XIV

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“…An ovarian tumor model was established by injecting 5 × 104 of SKOV3 luciferase gene positive human ovarian cancer cells orthotopically (right side) and subcutaneously (left side), respectively. Figure 4 shows the reconstructed FMT images along the transverse and sagittal planes for a tumor-bearing mouse Intraperitoneal (IP) injected with 290pmole NIR-830-ATF68-IONP, a peptide conjugated molecular probe loaded with both near-infrared dye and iron oxide nanoparticles that can target tumor cell receptors [28,29]. We can see that the tumors are well reconstructed in both cases.…”

Section: Animal Experimentsmentioning

confidence: 99%

FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery

Yang

Dai

et al. 2015

Photonics

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Abstract:We described a novel handheld device (termed FMTPen) for three-dimensional (3D) fluorescence molecular tomography (FMT). The FMTpen is characterized by its bendable structure and miniaturized size (10 mm in diameter) that can be potentially used as an intraoperative tool for the detection of tumor margins and for image-guided surgery. Several phantom experiments based on indocyanine green (ICG), an FDA approved near-infrared (NIR) fluorescent dye, were conducted to evaluate the imaging ability of this device. Two tumor-bearing mice were systematically injected with tumor-targeted NIR fluorescent probes (NIR-830-ATF68-IONP and NIR-830-ZHER2:343-IONP, respectively) and were then imaged to further demonstrate the ability of this FMT probe for imaging small animals.

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“…PAI is an emerging biomedical imaging technique that combines the optical contrast with an increased ratio of imaging depth to spatial resolution capable of providing anatomical, functional, molecular properties of biological tissue with a high resolution [22][23][24][25][26][27][28][29][30][31][32]. In PAI, images are formed through detecting pulsed laser-induced wideband acoustic waves.…”

Section: Introductionmentioning

confidence: 99%

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

et al. 2017

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It is highly desirable to develop novel approaches to improve patient survival rate of pancreatic cancer through early detection. Here, we present such an approach based on photoacoustic and fluorescence molecular imaging of pancreatic tumor using a miniature multimodal endoscope in combination with targeted multifunctional iron oxide nanoparticles (IONPs). A novel fan-shaped scanning mechanism was developed to minimize the invasiveness for endoscopic imaging of pancreatic tumors. The results show that the enhancements in photoacoustic and fluorescence signals using amino-terminal fragment (ATF) targeted IONPs were~four to six times higher compared to that using non-targeted IONPs. Our study indicates the potential of the combination of the multimodal photoacoustic-fluorescence endoscopy and targeted multifunctional nanoparticles as an efficient tool to provide improved specificity and sensitivity for pancreatic cancer detection.

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Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror

Cited by 41 publications

References 23 publications

Directionally Controlled Time-of-Flight Ranging for Mobile Sensing Platforms

Directionally Controlled Time-of-Flight Ranging for Mobile Sensing Platforms

FMTPen: A Miniaturized Handheld Fluorescence Molecular Tomography Probe for Image-Guided Cancer Surgery

Targeted Molecular Imaging of Pancreatic Cancer with a Miniature Endoscope

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