Hand grip strength: A reliable, reproducible, cost-effective tool to assess the nutritional status and outcomes of cirrhotics awaiting liver transplant

Daphnee, D.K.; John, Sheila; Vaidya, A; Khakhar, Anand; Bhuvaneshwari, S.; Ramamurthy, Anand

doi:10.1016/j.clnesp.2017.01.011

Cited by 22 publications

(11 citation statements)

References 20 publications

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“…Contrary to the CST, the prognosis value of HGS has been demonstrated in many works in patients with cirrhosis. HGS is an independent factor of mortality [33,34], but weakly correlates with muscle mass and quality assessed on cross-sectional imaging [35]. These results imply that the complementarity of a quantification with a functional approach is needed.…”

Section: How To Correctly Assess Muscle Function and Mass In Patientsmentioning

confidence: 97%

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Buchard¹,

Boirie²,

Cassagnes³

et al. 2020

Nutrients

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Malnutrition is a common comorbidity in patients with cirrhosis. Its prognostic value is indisputable as it greatly affects the evolution of liver diseases. It has a major impact on both morbi-mortality before and after liver transplantation. Being now integrated in the definition of malnutrition and recognized as a new entity in the international classification of diseases, physicians have taken great interest in sarcopenia. Its negative consequences on the fate of patients with cirrhosis are well-demonstrated. The concept of frailty has recently been enlarged to chronic liver diseases as symptoms of impaired global physical functioning. In this article, we will discuss the definitions of malnutrition and emphasize its links with sarcopenia and frailty. We will show the relevance of frailty and sarcopenia in the course of liver diseases. The emerging role of muscle depletion on the cardiorespiratory system will also be highlighted. The importance of body composition will be demonstrated and the main tools reviewed. Finally, we adapted the definition of malnutrition to patients with cirrhosis based on the assessment of sarcopenia together with reduced food intakes.

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Section: How To Correctly Assess Muscle Function and Mass In Patientsmentioning

confidence: 97%

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Buchard¹,

Boirie²,

Cassagnes³

et al. 2020

Nutrients

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show abstract

“…Patients with NAFLD have been shown to have higher odds for low muscle strength on HGS measurements irrespective of sociodemographic characteristics, weight, metabolic syndrome, and concurrent illnesses [ 81 ]. In patients with cirrhosis, studies have confirmed a correlation between decreased HGS and increasing mortality [ 82 , 83 ].…”

Section: Vitamin Dmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?

Mikolašević¹,

Pavić²,

Kanižaj

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology. However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed. Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD. Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD. Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of physical activity and nutritional interventions such as vitamin D supplementation. This review aims to report recent evidence concerning the links between sarcopenia and NAFLD and methods to assess sarcopenia.

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“…The functional assessments included HGS 21,22 and the SPPB 23 . A Jamar digital dynamometer was used to measure HGS, and the average of three readings from the dominant hand was recorded and poor HGS defined as <27 kg for males and <16 kg for females 3 .…”

Section: Methodsmentioning

confidence: 99%

The inter‐ and intrarater reliability and feasibility of dietetic assessment of sarcopenia and frailty in potential liver transplant recipients: A mixed‐methods study

et al. 2020

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Sarcopenia and frailty are associated with poorer outcomes in potential liver transplant (LT) recipients. We examined the reliability and feasibility of dietitians assessing sarcopenia and frailty. Seventy‐five adults referred for LT underwent assessments of muscle mass (abdominal CTs), physical function (handgrip strength; HGS, short physical performance battery; SPPB), and frailty (Liver Frailty Index; LFI). Inter‐ and intrarater reliability and agreement were assessed in subsets of patients using intraclass correlation coefficients (ICCs) and Bland‐Altman plots. CTs were analyzed by a dietitian and two independent experts, two dietitians assessed function and frailty. Feasibility assessed system, patient, and profession factors (staff survey). Inter‐ and intrarater reliability for CT‐defined low muscle were excellent (ICCs > 0.97). Reliability between dietitians was excellent for HGS (0.968, 95% CI, 0.928–0.986), SPPB (0.932, 95% CI, 0.798–0.973), and LFI (0.938, 95% CI 0.861–0.973). Bland‐Altman analysis indicated excellent agreement for HGS. All transplant clinicians valued sarcopenia and frailty in LT assessments and considered the dietitian appropriate to perform them. Seven saw no barriers to implementation into practice, while five queried test standardization, learning from repeat testing, and resource cost. Dietetic assessments of sarcopenia and frailty are reliable, feasible, and valued measures in the assessment of potential LT recipients.

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Hand grip strength: A reliable, reproducible, cost-effective tool to assess the nutritional status and outcomes of cirrhotics awaiting liver transplant

Cited by 22 publications

References 20 publications

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?

The inter‐ and intrarater reliability and feasibility of dietetic assessment of sarcopenia and frailty in potential liver transplant recipients: A mixed‐methods study

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