Hamartoma of the Breast in a Man: First Case Report

Ravakhah, Keyvan; Javadi, Nader; Simms, R.

doi:10.1046/j.1524-4741.2001.20079.x

Cited by 33 publications

(25 citation statements)

References 5 publications

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“…Six patients were above 35 years of age, and six patients were under 35. Three cases of breast hamartoma have been reported in the literature, which could also be seen in males (8)(9)(10). All patients in our series were female.…”

Section: Discussionmentioning

confidence: 64%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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Objective: Breast hamartomas are benign breast tumors, which are observed very rarely. We aimed to share our surgical approaches and a comparison of preoperative and postoperative pathology results of patients applying to breast polyclinics. Materials and Methods:Out of 32.000 patients approximately, we reviewed data of 12 patients with the diagnosis of breast hamartoma retrospectively, who had applied to the breast polyclinic between dates of March 2007 and October 2012.Results: All patients were female and their average age was 35 (17-58 years). Four of the hamartomas were detected in the right breast, and eight in the left breast. The average diameter of lesions was 7.3 cm (3-21cm). The diameter in our three cases was above 10 cm, and they were evaluated as giant hamartomas. All our cases underwent a fine needle aspiration biopsy (FNAB) or a core biopsy preoperatively. When the reports of preoperative biopsies performed on patients who had applied due to a palpable mass and the postoperative pathology reports were compared, it was detected that they showed a substantial correlation. Conclusion:Hamartomas are benign tumors of the breast. The rate of preoperative diagnosis is high when physical examination, imaging and histopathology approaches are taken in combination. Although very rare, a surgical excision should be performed due to the malignant change in tumors. Hamartomların dördü sağ memede sekizi sol memede saptandı. Lezyonların ortalama çapı 7,3 cm idi (min-maks; 3-21). Üç olguda lezyon çapı 10 cm üzerinde olup bu olgular dev hamartom olarak değerlendirildi. Olgularımı-zın hepsine preoperatif ince iğne aspirasyon biyopsisi (İİAB) veya kor biyopsi yapıldı. Ele gelen kitle ile başvuran hastalara yapılan preoperatif biyopsi ile postoperatif patoloji raporları karşılaştırıldığında büyük oranda korelasyon gösterdikleri tespit edildi.Sonuç: Hamartomlar memenin iyi huylu tümörleridir. Fizik muayene, gö-rüntüleme ve histopatolojinin birlikte ele alınmasıyla preoperatif tanı konma oranı yüksektir. Çok nadir de olsa malign değişim göstermesi sebebiyle cerrahi eksizyon yapılmalıdır.

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Section: Discussionmentioning

confidence: 64%

Surgical Approach to Breast Hamartoma and the Diagnostic Accuracy in Preoperative Biopsies

Tatar¹,

Erözgen²,

Tüzün³

et al. 2013

J Breasth Health

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“…Its exact incidence is not yet known as there have not been more than 35 cases of MH described in the literature, mainly as case reports [2][3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20]. The aetiopathogenesis of MH remains unclear, although there is a probable impact of female steroid hormones on cellular growth as all cases except one occurred in women [19]. Its prevalence is highest among postmenopausal women [7,16] where it may persist for several years [8,9].…”

Section: Case Reportmentioning

confidence: 99%

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Kajo¹,

Žúbor

Danko³

2010

Breast Care

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Background: Myoid (muscular) hamartoma (MH) of the breast is a rare benign tumour-forming lesion composed of differentiated mammary glandular and stromal structures, fatty tissue, and areas of smooth muscle. It is considered to be a variant of mammary hamartoma. Case Report: We report the case of a 46-year-old woman with MH, and provide a literature review explaining the origin of smooth muscle cells. Histologically, the tumour consisted of fibrolipomatous stroma containing ductal and lobular structures of the mammary gland located mainly at the tumour borders. The glandular structures showed signs of micro- and macrocystic changes, apocrine metaplasia, and adenosis. The dominant feature was the presence of a fascicular formation of spindle cells, predominantly in central parts, with incursion between glandular structures. Immunohistochemically, foci of smooth muscle tissue were positive for desmin, smooth muscle actin, and h-caldesmon. Oestrogen and progesterone receptors (PR) showed positive expression which was markedly higher for PR. There was negative expression of CD34, S-100 protein, and CD10. Conclusions: The origin of smooth muscle cells in MH is unknown. However, it is presumed to be derived from hormonally responsive breast stromal cells by smooth muscle metaplasia, based on evidence of hormone receptor expression in the lesion.

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“…Breast hamartomas are uncommon, benign, slow growing lesions of breast: the reported incidence is 0.7% of benign breast tumours in women [2]. The first report on the topic was by Arrigoni et al in 1971 [3].…”

Section: Discussionmentioning

confidence: 99%