Hamartoma of mature cardiac myocytes: a cardiac tumour with preserved contractility

A connective tissue pericardial hamartoma: A case report with literature review of cardiac hamartoma

“…Hamartoma is considered one of the rarest primary benign cardiac tumors which consists of overgrowth of a mixture of adult tissue with the capability for malignant transformation [2] . It was described initially in 1951 [6] , and until March 2022, only 34 cases were mentioned in the literature ( Table 1 ) [6] , [7] , [8] , [9] , [10] , [11] . Only two of them are located in the pericardium [6] , [9] .…”

“…Furthermore, in this study, we included all the 34 cases of epicardial, myocardial, and endocardial hamartoma in one table ( Table 1 ). We classified them according to the following: Year, Age, Sex, Location, Presentation, and Management ( Table 1 ) [6] , [7] , [8] , [9] , [10] , [11] .…”

A Rare Case of Cardiac Mesenchymal Hamartoma and Comprehensive Review of the Literature With Emphasis on Histopathology

“…In most prior studies, cardiac muscle differentiation of the muscular component of the cardiac hamartoma was assumed without ruling out smooth muscle components by staining for SMA (Table 1). 2,3,7,9,[12][13][14]16,17,[19][20][21][22]29 Striations of cardiomyocytes were infrequently described, and in 1 case the absence of cross striation was explicitly noted. 7 Galeone et al 15 reported "positive staining confirm[ing] the presence of cardiac myocytes, detected by antibodies to desmin and alpha-smooth actin"-while classifying the lesion as HMCM.…”

“…Forty-seven relevant cases of cardiac hamartoma were identified in the literature between 1970 and 2020 (Table 1). 2,3,7,9,[12][13][14]16,17,[19][20][21][22]29 The patient's ages ranged from 4 weeks to 74 years of age. Of the 47 cases, 23 were in pediatric patients and 24 were in adult patients.…”