Haloperidol-loaded polysorbate-coated polymeric nanocapsules decrease its adverse motor side effects and oxidative stress markers in rats

Benvegnú, Dalila Moter; Barcelos, Raquel Cristine Silva; Boufleur, Nardeli; Pase, Camila Simonetti; Reckziegel, Patrícia; Flores, Fernanda Cramer; Ourique, Aline Ferreira; Nora, Magali Dalla; Silva, Cristiane de Bona da; Beck, Ruy Carlos Ruver; Burger, Marilise Escobar

doi:10.1016/j.neuint.2012.06.015

Cited by 24 publications

(9 citation statements)

References 45 publications

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“…This is probably owing vectoring of the drug through the nanocapsules, the drug not undergo extensive hepatic metabolism and thus generating less toxic metabolites. Similar findings were obtained with haloperidol nanoencapsulado demonstrated the beneficial effects of nanocapsules the engine system, and resulting in lower oxidative damage in brain regions compared with free drug (Benvegnú et al 2012).…”

Section: Discussionsupporting

confidence: 82%

Clozapine linked to nanocapsules minimizes tissue and oxidative damage to biomolecules lipids, proteins and DNA in brain of rats Wistar

et al. 2014

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Clozapine, atypical antipsychotic, can change oxidative stress parameters. It is known that reactive species, in excess, can have a crucial role in the etiology of diseases, as well as, can potentiating adverse effects induce by drugs. The nanocapsules have attracted attention as carriers of several drugs, with consequent reduction of adverse effects. This study aimed to evaluate histopathology and oxidative damage of biomolecules lipids, proteins and DNA in the brain of Wistar rats after treatment with nanocapsules containing clozapine. The study consisted of eight groups of male Wistar rats (n = 6): saline (SAL), free clozapine (CZP) (25 mg/Kg i.p.), blank uncoated nanocapsules (BNC), clozapine-loaded uncoated nanocapsules (CNC) (25 mg/Kg i.p.), blank chitosan-coated nanocapsules (BCSN), clozapine-loaded chitosan-coated nanocapsules (CCSN) (25 mg/Kg i.p.), blank polyethyleneglycol-coated nanocapsules (BPEGN), clozapine-loaded polyethyleneglycol-coated nanocapsules (CPEGN) (25 mg/Kg i.p.). The animals received the formulation once a day for seven consecutive days and euthanized in the eighth day. After euthanasia, the brain was collected and homogenate was processed for further analysis. The histopathology showed less brain tissue damage in nanocapsules-treated groups. The lipid peroxidation and carbonylation of proteins showed a significant increase (p < 0.05) induced by CZP. CNC and CPEGN groups obtained a reduction membrane of lipids damage and nanocapsules-treated groups showed significant improvement protein damage. CZP was able to induce genetic oxidative damage, while the nanocapsules causing less damage to DNA. The findings show that different coatings can act protecting target tissues decreasing oxidative damage, suggesting that the drug when linked to different nanocapsules is able to mitigate the harmful effects of clozapine.

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Section: Discussionsupporting

confidence: 82%

Clozapine linked to nanocapsules minimizes tissue and oxidative damage to biomolecules lipids, proteins and DNA in brain of rats Wistar

et al. 2014

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“…In this case, the negative zeta potential value is close to zero as a consequence of the chemical composition (polyester coated by polysorbate 80), in which stabilization mechanism is based on the steric hindrance effect. 13,34 The reproducibility of size distribution batch-to-batch shows that the formulation is kinetically stable, ie, the system has a delayed aggregation phase separation. The PCL used in the nanocapsule formulation has -COOH end groups, which can present an acidbase balance forming carboxylates, rendering the surface negatively charged.…”

Section: Resultsmentioning

confidence: 99%

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Quintans-Júnior

Frank

Lima

et al. 2017

IJN

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Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials.

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“…The main advantages of nanocapsules towards drug delivery applications were sustained release property, incremental drug selectivity, improved bioavailability and alleviation of drug toxicity [80]. In addition, polymeric nanocapsules enhance the safety and efficacy of drugs by increasing their aqueous solubility, protecting them from degradation, controlling release, enhancing bioavailability and tissue selectivity [81][82][83][84]. The diversified applications of nanocapsules in various fields includes, agrochemicals, genetic engineering, cosmetics, wastewater treatments, adhesive component applications, delivery of the drug to tumours, radiotherapy and as liposomal nanocapsules in food science/ agriculture [85].…”

Section: Nanocapsules For the Treatment Of Ramentioning

confidence: 99%

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Janakiraman

Krishnaswami

Rajendran

et al. 2018

Materials Today Communications

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A B S T R A C TRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10 were responsible for the induction of inflammation in RA patients. Drawbacks such as poor efficacy, higher doses, frequent administration, low responsiveness, and higher cost and serious side effects were associated with the conventional dosage forms for RA treatment. Nanomedicines were recently gaining more interest towards the treatment of RA, and researchers were also focusing towards the development of various anti-inflammatory drug loaded nanoformulations with an aid to both actively/passively targeting the inflamed site to afford an effective treatment regimen for RA. Alterations in the surface area and nanoscale size of the nanoformulations elicit beneficial physical and chemical properties for better pharmacological activities. These drug loaded nanoformulations may enhances the solubility of poorly water soluble drugs, improves the bioavailability, affords targetability and may improve the therapeutic activity. In this regimen, the present review focus towards the novel nanoparticulate formulations (nanoparticles, nanoemulsions, solid lipid nanoparticles, nanomicelles, and nanocapsules) utilized for the treatment of RA. The recent advancements such as siRNA, peptide and targeted based nanoparticulate systems for RA treatment were also discussed. Special emphasis was provided regarding the pathophysiology, prevalence and symptoms towards the development of RA.

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Haloperidol-loaded polysorbate-coated polymeric nanocapsules decrease its adverse motor side effects and oxidative stress markers in rats

Cited by 24 publications

References 45 publications

Clozapine linked to nanocapsules minimizes tissue and oxidative damage to biomolecules lipids, proteins and DNA in brain of rats Wistar

Clozapine linked to nanocapsules minimizes tissue and oxidative damage to biomolecules lipids, proteins and DNA in brain of rats Wistar

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

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