Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Veselý, Petr; Stračina, Tibor; Hlaváčová, Miroslava; Halámek, Josef; Kolářová, Jana; Olejníčková, Veronika; Mrkvicová, Veronika; Paulová, Hana; Novàkovâ, Marie

doi:10.1016/j.jphs.2018.11.004

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…Detailed analysis of QT duration in rabbit protocols with drug-induced long-QT or short-QT syndrome indicated the possible effect of acute mechano-electrical function on long-QT syndrome–related arrhythmogenesis ( Nimani et al, 2021 ). Generally, this feature is a basic marker used in a wide range of proarrhythmic research studies, including those conducted in transgenic rabbit models ( Baczkó et al, 2020 ), larval zebrafish models ( Barrett et al, 2021 ), and guinea pig isolated heart models ( Vesely et al, 2019 ). So-called QT/RR coupling and—though rarely used—HRV analysis can be successfully evaluated in such studies, as previously shown in the context of haloperidol administration in isolated Sprague Dawley rat and guinea pig models ( Janousek et al, 2017 ; Vesely et al, 2019 ).…”

Section: Ecg Analysismentioning

confidence: 99%

“…Generally, this feature is a basic marker used in a wide range of proarrhythmic research studies, including those conducted in transgenic rabbit models ( Baczkó et al, 2020 ), larval zebrafish models ( Barrett et al, 2021 ), and guinea pig isolated heart models ( Vesely et al, 2019 ). So-called QT/RR coupling and—though rarely used—HRV analysis can be successfully evaluated in such studies, as previously shown in the context of haloperidol administration in isolated Sprague Dawley rat and guinea pig models ( Janousek et al, 2017 ; Vesely et al, 2019 ). The prolonged QT duration was found in the methylazoxymethanol acetate rat model of schizophrenia, which has indicated the models’ applicability for investigating the risk factors of ventricular arrhythmias and sudden cardiac death in patients treated with antipsychotics drugs ( Stracina et al, 2016 ).…”

Section: Ecg Analysismentioning

confidence: 99%

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Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

et al. 2022

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Cardiovascular system and its functions under both physiological and pathophysiological conditions have been studied for centuries. One of the most important steps in the cardiovascular research was the possibility to record cardiac electrical activity. Since then, numerous modifications and improvements have been introduced; however, an electrocardiogram still represents a golden standard in this field. This paper overviews possibilities of ECG recordings in research and clinical practice, deals with advantages and disadvantages of various approaches, and summarizes possibilities of advanced data analysis. Special emphasis is given to state-of-the-art deep learning techniques intensely expanded in a wide range of clinical applications and offering promising prospects in experimental branches. Since, according to the World Health Organization, cardiovascular diseases are the main cause of death worldwide, studying electrical activity of the heart is still of high importance for both experimental and clinical cardiology.

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Section: Ecg Analysismentioning

confidence: 99%

Section: Ecg Analysismentioning

confidence: 99%

Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

et al. 2022

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“…Blocking I Kr channels QTc prolongation [26][27][28] Haloperidol [29][30][31][32] Ziprasidone [32,33] Moderate risk Amisulpride (oral)…”

Section: Chlorpromazinementioning

confidence: 99%

“…Blocking I Kr channels QTc prolongation [34,35] Clozapine [36,37] Flupentixol [38] Haloperidol (oral) [29][30][31][32] Olanzapine [26,39,40] Pimozide [32,40,41] Quetiapine [32,40,42] Risperidone [32,40] Thioridazine [28,32,40,43] Mesoridazine [32,33] Perphenazine [28] Trifluoperazine [28] Sertindole [40] Sulpiride [40] Low risk…”

Section: Chlorpromazinementioning

confidence: 99%

Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia

Vaiman

Shnayder²,

Zhuravlev³

et al. 2022

IJMS

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Antipsychotics (AP) induced prolongation of the QT interval in patients with schizophrenia (Sch) is an actual interdisciplinary problem as it increases the risk of sudden death syndrome. Long QT syndrome (LQTS) as a cardiac adverse drug reaction is a multifactorial symptomatic disorder, the development of which is influenced by modifying factors (APs’ dose, duration of APs therapy, APs polytherapy, and monotherapy, etc.) and non-modifying factors (genetic predisposition, gender, age, etc.). The genetic predisposition to AP-induced LQTS may be due to several causes, including causal mutations in the genes responsible for monoheme forms of LQTS, single nucleotide variants (SNVs) of the candidate genes encoding voltage-dependent ion channels expressed both in the brain and in the heart, and SNVs of candidate genes encoding key enzymes of APs metabolism. This narrative review summarizes the results of genetic studies on AP-induced LQTS and proposes a new personalized approach to assessing the risk of its development (low, moderate, high). We recommend implementation in protocols of primary diagnosis of AP-induced LQTS and medication dispensary additional observations of the risk category of patients receiving APs, deoxyribonucleic acid profiling, regular electrocardiogram monitoring, and regular therapeutic drug monitoring of the blood APs levels.

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“…Flufenamic acid NSAID 14 0.137 ± 0.017 (EC50) Hypertension and congestive heart failure (Miyamori et al, 1985) 600 mg >350 (without First Pass Effect)* Haloperidol Antipsychotic 10 30 (TC) Prolongation of QT interval, torsades de pointes, sudden cardiac death (Meyer-Massetti et al, 2010;Fernandes et al, 2018;Vesely et al, 2019) (Basyigit et al, 2005;Lu et al, 2015;Okeahialam, 2015) 500 mg/day i.v. Prolongation of QT interval, torsades de pointes, bradycardia, asystole (Malizia et al, 1980;Danze and Langdorf, 1991;Luzza et al, 2006) 16.2 mg/L >60 18 (EC50) AV block, ventricular premature contraction and/or ventricular tachycardia (rats) (Lee et al, 1972(Lee et al, , 1974Lin et al, 1992) 1300 mg (65 kg human, 20 mg/kg i.v.…”

Section: >20*mentioning

confidence: 99%

A Bitter Taste in Your Heart

2020

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The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel function varies between individuals and is underpinned by naturally occurring T2R polymorphisms, which have also been associated with disease. Recent studies have reported the expression of T2Rs and their downstream signaling components within non-gustatory tissues, including the heart. Though the precise role of T2Rs in the heart remains unclear, evidence points toward a role in cardiac contractility and overall vascular tone. In this review, we summarize the extra-oral expression of T2Rs, focusing on evidence for expression in heart; we speculate on the range of potential ligands that may activate them; we define the possible signaling pathways they activate; and we argue that their discovery in heart predicts an, as yet, unappreciated cardiac physiology.

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Haloperidol affects coupling between QT and RR intervals in guinea pig isolated heart

Cited by 8 publications

References 29 publications

Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia

A Bitter Taste in Your Heart

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