Halogenated aromatic hydrocarbon-induced suppression of the plaque-forming cell response in B6C3F1 splenocytes cultured with allogenic mouse serum: Ah receptor structure activity relationships

Immunotoxicity of environmentally relevant mixtures of polychlorinated aromatic hydrocarbons with methyl mercury on rat lymphocytes in vitro

“…In addition, the concentrations of TCDD (1 and 15 pg/ml) used in our study did not suppress lymphocyte proliferation to B and T cell mitogens. The immunosuppressive effects of commercial Aroclor PCB mixtures, PCDDs, and PCDFs at high exposure levels have been demonstrated in experiments with animals [2,3,19–21]. The present study with low environmental levels of PCB or PCDD/PCDF mixtures revealed no suppressive effects on the proliferative function of rat peripheral blood and lymphoid lymphocytes to T and B cell mitogens.…”

Immunotoxicity of environmentally relevant mixtures of polychlorinated aromatic hydrocarbons with methyl mercury on rat lymphocytes in vitro

“…In addition, the concentrations of TCDD (1 and 15 pg/ml) used in our study did not suppress lymphocyte proliferation to B and T cell mitogens. The immunosuppressive effects of commercial Aroclor PCB mixtures, PCDDs, and PCDFs at high exposure levels have been demonstrated in experiments with animals [2,3,19–21]. The present study with low environmental levels of PCB or PCDD/PCDF mixtures revealed no suppressive effects on the proliferative function of rat peripheral blood and lymphoid lymphocytes to T and B cell mitogens.…”

Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.

“…The TEF for each 2,3,7,8-substituted congener compared to TCDD is variable among cell types, laboratory animal species, target organs, and responses. Research in our laboratory has extensively investigated the immunotoxicity-derived TEFs for several HAHs in mouse models (47)(48)(49)(50); TEFs for inhibition of the plaque-forming cell response to trinitrophenyl-lipopolysaccharide by 2,3,4,7,8pentachlorodibenzofuran in C57BL/6, DBA/2, and B6C3F1 mice varied by approximately 7-fold, and in some assays this congener was more potent than TCDD. Over a broader spectrum of responses, TEFs for individual PCDD/ PCDF congeners can vary by over 100-fold.…”

Regulation of PreB Cell Apoptosis by Aryl Hydrocarbon Receptor/Transcription Factor‐Expressing Stromal/Adherent Cells

“…Indeed, the developing immune system appears to be particularly susceptible to AhR ligands (38)(39)(40). In some, but not all model systems, immunosuppression induced by PAH or HAH is dependent on AhR activation (22,25,28,41).…”

Immunotoxicity of environmentally relevant mixtures of polychlorinated aromatic hydrocarbons with methyl mercury on rat lymphocytes in vitro

“…In addition, the concentrations of TCDD (1 and 15 pg/ml) used in our study did not suppress lymphocyte proliferation to B and T cell mitogens. The immunosuppressive effects of commercial Aroclor PCB mixtures, PCDDs, and PCDFs at high exposure levels have been demonstrated in experiments with animals [2,3,19–21]. The present study with low environmental levels of PCB or PCDD/PCDF mixtures revealed no suppressive effects on the proliferative function of rat peripheral blood and lymphoid lymphocytes to T and B cell mitogens.…”

Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.

“…The TEF for each 2,3,7,8-substituted congener compared to TCDD is variable among cell types, laboratory animal species, target organs, and responses. Research in our laboratory has extensively investigated the immunotoxicity-derived TEFs for several HAHs in mouse models (47)(48)(49)(50); TEFs for inhibition of the plaque-forming cell response to trinitrophenyl-lipopolysaccharide by 2,3,4,7,8pentachlorodibenzofuran in C57BL/6, DBA/2, and B6C3F1 mice varied by approximately 7-fold, and in some assays this congener was more potent than TCDD. Over a broader spectrum of responses, TEFs for individual PCDD/ PCDF congeners can vary by over 100-fold.…”

Regulation of PreB Cell Apoptosis by Aryl Hydrocarbon Receptor/Transcription Factor‐Expressing Stromal/Adherent Cells

“…Indeed, the developing immune system appears to be particularly susceptible to AhR ligands (38)(39)(40). In some, but not all model systems, immunosuppression induced by PAH or HAH is dependent on AhR activation (22,25,28,41).…”

Immunotoxicity of environmentally relevant mixtures of polychlorinated aromatic hydrocarbons with methyl mercury on rat lymphocytes in vitro

“…In addition, the concentrations of TCDD (1 and 15 pg/ml) used in our study did not suppress lymphocyte proliferation to B and T cell mitogens. The immunosuppressive effects of commercial Aroclor PCB mixtures, PCDDs, and PCDFs at high exposure levels have been demonstrated in experiments with animals [2,3,19–21]. The present study with low environmental levels of PCB or PCDD/PCDF mixtures revealed no suppressive effects on the proliferative function of rat peripheral blood and lymphoid lymphocytes to T and B cell mitogens.…”

Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach.

“…The TEF for each 2,3,7,8-substituted congener compared to TCDD is variable among cell types, laboratory animal species, target organs, and responses. Research in our laboratory has extensively investigated the immunotoxicity-derived TEFs for several HAHs in mouse models (47)(48)(49)(50); TEFs for inhibition of the plaque-forming cell response to trinitrophenyl-lipopolysaccharide by 2,3,4,7,8pentachlorodibenzofuran in C57BL/6, DBA/2, and B6C3F1 mice varied by approximately 7-fold, and in some assays this congener was more potent than TCDD. Over a broader spectrum of responses, TEFs for individual PCDD/ PCDF congeners can vary by over 100-fold.…”

Regulation of PreB Cell Apoptosis by Aryl Hydrocarbon Receptor/Transcription Factor‐Expressing Stromal/Adherent Cells

“…Indeed, the developing immune system appears to be particularly susceptible to AhR ligands (38)(39)(40). In some, but not all model systems, immunosuppression induced by PAH or HAH is dependent on AhR activation (22,25,28,41).…”