Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo

Nordlund, James J.

doi:10.1001/archderm.116.6.690

Cited by 11 publications

(4 citation statements)

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“…More support for the role of central melanin is forthcoming from the observations of patients with depigmenting disorders who display the Vogt-Koyanagi-Harada syndrome (Nordlund et al, 1980). This includes aseptic meningitis, dysacousia, and uveitis that can be attributed to the missing melanin function in the meninges, the inner ear, and the eye, respectively; hence, an absence of melanin in the pituitary could cause endocrine disturbances, such as the alopecia, which is also commonly observed in those patients.…”

Section: Discussionmentioning

confidence: 99%

Hypophysial and Meningeal Melanocytes in the Zucker Rat

Fetissov¹,

Barcza²,

Meguid

et al. 1999

Pigment Cell Research

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Melanocytes have not been described in the pituitary of mammals or in the meninges of the rat. In this paper, we report the presence of the cluster of melanocytes in the intermediate lobe of the pituitary and around the median eminence of the hypothalamus forming an 'infundibulo-hypophysial circle', and also describe the characteristics of meningeal melanocytes in Zucker rats. In the leptomeninges, numerous melanocytes were found on the ventrolateral surface of cerebral hemisphere in the area of the middle cerebral artery. Pigment granules were also observed in the surrounding tissue outside the melanocytes as well as incorporated in the cytoplasm of neural and epithelial cells. Electron microscopy revealed that melanosomes in hypophysial and meningeal melanocytes were in different (II-IV) stages of maturity. In the leptomeninges of Zucker rats, HMB-45 immunoreactivity was found in round non-melanosome-containing cells, while no HMB-45 reaction was found in the leptomeninges of the albino rat. We conclude that both obese and lean Zucker rats possess functionally active melanocytes in the meninges and the pituitary and transfer pigment granules to neighboring cells. The distributions of melanocytes in proximity to blood vessels in the leptomeninges and in the 'infundibulo-hypophysial circle' suggest an endocrine secretory function.

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Section: Discussionmentioning

confidence: 99%

Hypophysial and Meningeal Melanocytes in the Zucker Rat

Fetissov¹,

Barcza²,

Meguid

et al. 1999

Pigment Cell Research

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“…There is strong evidence that cell-mediated immunity plays an important role in the disease. Reports of patients with VKH disease who developed limited vitiligo following inflammatory erythema suggest an immune reaction to the pigment cells [5, 6, 7]. Hague [5]described a patient who had faint erythema on the margin of vitiligo in 1944.…”

Section: Discussionmentioning

confidence: 99%

“…Hague [5]described a patient who had faint erythema on the margin of vitiligo in 1944. A 10-year-old boy with VKH disease was noted to have a rash accompanied by petechiae on his right eye lid and right forehead that preceded the vitiligo in these areas [6]. Vitiligo occurring with an inflammatory erythema on the face in VKH disease has also been reported in a 35-year-old Japanese woman, 2 years after the onset of bilateral uveitis and dysacousis [7].…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease: Extensive Vitiligo with Prodromal Generalized Erythroderma

Wong

Ng²,

Lee³

1999

Dermatology

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The occurrence of vitiligo with prodromal erythema in Vogt-Koyanagi-Harada (VKH) disease is rarely observed. We describe a 68-year-old Chinese woman who developed extensive vitiligo 6 months after the onset of a generalized erythroderma and 12 months after the onset of acute bilateral uveitis. She also had a 4-year history of psoriatic plaques on the trunk which resolved completely without recurrence 15 months after the onset of erythroderma. The extensive cutaneous inflammation prior to the onset of vitiligo in our patient with VKH disease has not been reported before and strongly suggests an immunologic etiology for VKH disease.

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“…Associated with Koebnerisation. Other cutaneous abnormalities like leukotrichia, premature grey hair, 3 halo nevi 4 and alopecia areata 5,6 may be associated with vitiligo. Peak age of incidence of vitiligo in children is the first two decades of life.…”

Section: Introductionmentioning

confidence: 99%

Clinical Study of Vitiligo in Paediatric Population

Chekuri¹,

Pinjala²,

Thakur³

et al. 2016

jebmh

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Vitiligo is an acquired pigmentary anomaly of the skin manifested by depigmented white patches surrounded by a normal or a hyperpigmented border. We studied the clinical profile of vitiligo in paediatric population in Osmania General Hospital over a period of one year from February 2011 to January 2012. METHODS A total of fifty cases of children attending the vitiligo clinic of DVL Department at OGH, Hyderabad were studied. All the children attending the clinic were screened and the sample obtained on fulfilment of the selection criteria. Thirty consecutive adult patients attending the same clinic were taken as controls. This study attempts to identify and understand the features of vitiligo in the paediatric population like clinical spectrum of the disease, demographic features, associated diseases, familial predisposition and to compare all the above to the same features in adult vitiligo patients. RESULTS Out of 50 cases the mean age of the children in the study group was 9.71 yrs. while that of adults in control group was 30.26 yrs. The male female ratio in children was 2.1:2.9 and 7:9 in adults. The predominant site was the extremities mainly the lower limbs followed by face. 60 % of the cases were stable. Trauma was commonest predisposing event associated with 20% of children. CONCLUSIONS In our study the mean age of children at presentation was higher than other studies. Sex distribution was not significant. Course of the disease was found to be stable. The incidence of predisposing factors was found to be higher in children like trauma, febrile illness and contact with colours/paints, etc. The most common clinical variety was generalised and high incidence of dental caries was noted in the study group.

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Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo

Cited by 11 publications

References 0 publications

Hypophysial and Meningeal Melanocytes in the Zucker Rat

Hypophysial and Meningeal Melanocytes in the Zucker Rat

Vogt-Koyanagi-Harada Disease: Extensive Vitiligo with Prodromal Generalized Erythroderma

Clinical Study of Vitiligo in Paediatric Population

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