Halo congenital nevus

Abstract

A 24-year-old woman noted a depigmented halo around a pigmented lesion that had been present on her abdomen since birth. The halo and the central pigmented zone showed no change during the following year. Light and electron microscopic studies disclosed an uninflamed nevus extending to the deep reticular dermis; peripherally, the basal layer of the epidermis was depigmented. These findings indicate that a halo may develop about an uninflamed nevus that does not involute, and that the nevus may show the specific histopathology of congenital nevus.

Leukoderma In Association with Giant Congenital Nevi: Report of Two Cases

“…An immunolo gic mechanism has been postulated for the development of this hypopigmentation based on both the hispathology of the lesions and the association between vitiligo and halo nevi mentioned above. In the study by Berger and Voorhees, as well as in other studies [4,19,22], a dense lymphohistiocytic infiltrate in the dermis surrounding halo nevi has been observed.…”

“…Congenital nevi, in con trast to melanoma, have rarely been associated with pig ment loss. Patients with congenital halo nevi in the absence of an associated melanoma have been observed [4][5][6]. Reported here are two patients with giant congenital nevi associated with leukoderma who have been followed at the Pigmented Lesion Clinic (PLC) at the Massachusetts Gen eral Hospital.…”

Leukoderma In Association with Giant Congenital Nevi: Report of Two Cases

“…An immunolo gic mechanism has been postulated for the development of this hypopigmentation based on both the hispathology of the lesions and the association between vitiligo and halo nevi mentioned above. In the study by Berger and Voorhees, as well as in other studies [4,19,22], a dense lymphohistiocytic infiltrate in the dermis surrounding halo nevi has been observed.…”

“…Congenital nevi, in con trast to melanoma, have rarely been associated with pig ment loss. Patients with congenital halo nevi in the absence of an associated melanoma have been observed [4][5][6]. Reported here are two patients with giant congenital nevi associated with leukoderma who have been followed at the Pigmented Lesion Clinic (PLC) at the Massachusetts Gen eral Hospital.…”

Halo balloon cell nevus

“…Presenting clinically with a halo, and histologically showing an admixture of nevocellular nevus cells and a lytnphocytic infiltrate wilh a trtarked decrease in the atnount of stainable melanin in the surrounding epidermis, our case shows the classic features of an inflatntnatory halo nevus (2,3,10,11). A variety of lesions in addition to melanocytic nevi have been described as clinically with a halo, including blue nevi, neutoid nevi, congenital nevi, tnalignant tnelanotna and neurofibromata (3,10,12,13).…”

Melanocytic Nevi

“…Though usually single (Kopf et al 1965), multiple halo nevi have been reported (Jhung et al 1973). A majority of the halo nevi occur after birth, but congenital halo nevi are known to occur (Brownstein et al 1977).…”

“…The number of Langerhans' cells is increased (Swanson et al 1968), a process similar to that which occurs in vitiligo. Although recent electron microscopic (Jacobs et al 1975) and immunologic studies (Copeman et al 1973) favor an inflammatory immune reaction as the tnechanism of halo nevus, in some cases no inflammatory reaction is seen (Brownstein et al 1977, Gautheir et al 1975.…”

Leukoderma In Association with Giant Congenital Nevi: Report of Two Cases

“…An immunolo gic mechanism has been postulated for the development of this hypopigmentation based on both the hispathology of the lesions and the association between vitiligo and halo nevi mentioned above. In the study by Berger and Voorhees, as well as in other studies [4,19,22], a dense lymphohistiocytic infiltrate in the dermis surrounding halo nevi has been observed.…”

“…Congenital nevi, in con trast to melanoma, have rarely been associated with pig ment loss. Patients with congenital halo nevi in the absence of an associated melanoma have been observed [4][5][6]. Reported here are two patients with giant congenital nevi associated with leukoderma who have been followed at the Pigmented Lesion Clinic (PLC) at the Massachusetts Gen eral Hospital.…”

Halo balloon cell nevus

“…Presenting clinically with a halo, and histologically showing an admixture of nevocellular nevus cells and a lytnphocytic infiltrate wilh a trtarked decrease in the atnount of stainable melanin in the surrounding epidermis, our case shows the classic features of an inflatntnatory halo nevus (2,3,10,11). A variety of lesions in addition to melanocytic nevi have been described as clinically with a halo, including blue nevi, neutoid nevi, congenital nevi, tnalignant tnelanotna and neurofibromata (3,10,12,13).…”

Melanocytic Nevi

“…Though usually single (Kopf et al 1965), multiple halo nevi have been reported (Jhung et al 1973). A majority of the halo nevi occur after birth, but congenital halo nevi are known to occur (Brownstein et al 1977).…”

“…The number of Langerhans' cells is increased (Swanson et al 1968), a process similar to that which occurs in vitiligo. Although recent electron microscopic (Jacobs et al 1975) and immunologic studies (Copeman et al 1973) favor an inflammatory immune reaction as the tnechanism of halo nevus, in some cases no inflammatory reaction is seen (Brownstein et al 1977, Gautheir et al 1975.…”

Leukoderma In Association with Giant Congenital Nevi: Report of Two Cases

“…An immunolo gic mechanism has been postulated for the development of this hypopigmentation based on both the hispathology of the lesions and the association between vitiligo and halo nevi mentioned above. In the study by Berger and Voorhees, as well as in other studies [4,19,22], a dense lymphohistiocytic infiltrate in the dermis surrounding halo nevi has been observed.…”

“…Congenital nevi, in con trast to melanoma, have rarely been associated with pig ment loss. Patients with congenital halo nevi in the absence of an associated melanoma have been observed [4][5][6]. Reported here are two patients with giant congenital nevi associated with leukoderma who have been followed at the Pigmented Lesion Clinic (PLC) at the Massachusetts Gen eral Hospital.…”

Halo balloon cell nevus

“…Presenting clinically with a halo, and histologically showing an admixture of nevocellular nevus cells and a lytnphocytic infiltrate wilh a trtarked decrease in the atnount of stainable melanin in the surrounding epidermis, our case shows the classic features of an inflatntnatory halo nevus (2,3,10,11). A variety of lesions in addition to melanocytic nevi have been described as clinically with a halo, including blue nevi, neutoid nevi, congenital nevi, tnalignant tnelanotna and neurofibromata (3,10,12,13).…”

Melanocytic Nevi

“…Though usually single (Kopf et al 1965), multiple halo nevi have been reported (Jhung et al 1973). A majority of the halo nevi occur after birth, but congenital halo nevi are known to occur (Brownstein et al 1977).…”

“…The number of Langerhans' cells is increased (Swanson et al 1968), a process similar to that which occurs in vitiligo. Although recent electron microscopic (Jacobs et al 1975) and immunologic studies (Copeman et al 1973) favor an inflammatory immune reaction as the tnechanism of halo nevus, in some cases no inflammatory reaction is seen (Brownstein et al 1977, Gautheir et al 1975.…”