Hair regrowth in alopecia areata patients following Stem Cell Educator therapy

Li, Yanjia; Yan, Bowei; Wang, Hepeng; Li, Heng; Li, Quanhai; Zhao, Dong; Chen, Yana; Zhang, Ye; Li, Wenxia; Zhang, Jun; Wang, Shanfeng; Shen, Jie; Li, Yunxiang; Guindi, Edward; Zhao, Yong

doi:10.1186/s12916-015-0331-6

Cited by 61 publications

(62 citation statements)

References 51 publications

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“…Stem cell educator therapy has shown some initial success 203 . This approach uses a closed-loop system to isolate mononuclear cells derived from patients with alopecia areata, allows them to interact with human cord blood-derived multipotent stem cells, and then returns the “educated” cells into the patient’s circulation.…”

Section: Discussionmentioning

confidence: 99%

Alopecia areata

Pratt

King

Messenger

et al. 2017

Nat Rev Dis Primers

553

528

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Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair bearing sites. Patchy alopecia affecting the scalp is the most common type. Alopecia areata affects nearly 2% of the general population at some point during their lifetime. Skin biopsies of alopecia areata affected skin show a lymphocytic infiltrate in and around the bulb or the lower part of the hair follicle in anagen (hair growth) phase. A breakdown of immune privilege of the hair follicle is thought to be an important driver of alopecia areata. Genetic studies in patients and mouse models showed that alopecia areata is a complex, polygenic disease. Several genetic susceptibility loci were identified associated with signaling pathways that are important to hair follicle cycling and development. Alopecia areata is usually diagnosed based on clinical manifestations, but dermoscopy and histopathology can be helpful. Alopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the near future.

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Section: Discussionmentioning

confidence: 99%

Alopecia areata

Pratt

King

Messenger

et al. 2017

Nat Rev Dis Primers

553

528

View full text Add to dashboard Cite

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“…Thus, AA frequently remits spontaneously, presumably as a result of reestablishment of HF IP [1]. One major challenge of future AA therapy should be, then, to accelerate and promote this process (for detailed review, see [1,4,5,13,43,44]) (Fig. 2).…”

Section: Aa Disease Immunopathogenesismentioning

confidence: 99%

Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies

Gilhar

Schrum

Etzioni³

et al. 2016

Autoimmunity Reviews

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One of the most common human autoimmune diseases, alopecia areata (AA), is characterized by sudden, often persisting and psychologically devastating hair loss. Animal models have helped greatly to elucidate critical cellular and molecular immune pathways in AA. The two most prominent ones are inbred C3H/HeJ mice which develop an AA-like hair phenotype spontaneously or after experimental induction, and healthy human scalp skin xenotransplanted onto SCID mice, in which a phenocopy of human AA is induced by injecting IL-2-stimulated PBMCs enriched for CD56+/NKG2D+ cells intradermally. The current review critically examines the pros and cons of the available AA animal models and how they have shaped our understanding of AA pathobiology, and the development of new therapeutic strategies. AA is thought to arise when the hair follicle’s (HF) natural immune privilege (IP) collapses, inducing ectopic MHC class I expression in the HF epithelium and autoantigen presentation to autoreactive CD8+ T cells. In common with other autoimmune diseases, upregulation of IFN-γ and IL-15 is critically implicated in AA pathogenesis, as are NKG2D and its ligands, MICA, and ULBP3. The C3H/HeJ mouse model was used to identify key immune cell and molecular principles in murine AA, and proof-of-principle that Janus kinase (JAK) inhibitors are suitable agents for AA management in vivo, since both IFN-γ and IL-15 signal via the JAK pathway. Instead, the humanized mouse model of AA has been used to demonstrate the previously hypothesized key role of CD8+ T cells and NKG2D+ cells in AA pathogenesis and to discover human-specific pharmacologic targets like the potassium channel Kv1.3, and to show that the PDE4 inhibitor, apremilast, inhibits AA development in human skin. As such, AA provides a model disease, in which to contemplate general challenges, opportunities, and limitations one faces when selecting appropriate animal models in preclinical research for human autoimmune diseases.

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“…After injection of the cultured bulge and DP cells into deep dermis, epidermis forming ability of the cells was assessed. The authors suggested their methodology as a relevant source of bioengineered hair follicles for hair transplantation therapies in alopecia [120].…”

Section: Preliminary Hair Follicle Generation Studies and Obstacles Imentioning

confidence: 99%

Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet-rich plasma, low-level light therapy, and stem-cell therapy with variable outcomes are reviewed in this chapter.

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Hair regrowth in alopecia areata patients following Stem Cell Educator therapy

Cited by 61 publications

References 51 publications

Alopecia areata

Alopecia areata

Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies

Cosmetic Procedures in the Treatment of Alopecia

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