ORAI1 is a pore subunit of the store-operated Ca 2؉ release-activated Ca 2؉ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of the Orai1 gene. The results of immunohistochemical analysis showed that ORAI1 is expressed in lymphocytes, skin, and muscle of wild-type mice and is not expressed in Orai1 ؊/؊ mice. Orai1 ؊/؊ mice with the inbred C57BL/6 background showed perinatal lethality, which was overcome by crossing them to outbred ICR mi…
scite is a Brooklyn-based startup that helps researchers better discover and evaluate scientific articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by researchers from dozens of countries and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.