volume 28, issue 17, P5209-5222 2008
DOI: 10.1128/mcb.00360-08
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Abstract: ORAI1 is a pore subunit of the store-operated Ca 2؉ release-activated Ca 2؉ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of the Orai1 gene. The results of immunohistochemical analysis showed that ORAI1 is expressed in lymphocytes, skin, and muscle of wild-type mice and is not expressed in Orai1 ؊/؊ mice. Orai1 ؊/؊ mice with the inbred C57BL/6 background showed perinatal lethality, which was overcome by crossing them to outbred ICR mi…

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