Hair Graying in Substance Addiction

Reece, Albert Stuart

doi:10.1001/archderm.143.1.116

Cited by 40 publications

(35 citation statements)

References 6 publications

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“…Although these signal accomplishments are valuable and widely acknowledged, long-term agonist-based treatments have also been shown to be associated with appreciable mortality rates in both the medium (Brugal et al, 2005) and longer term (Hser et al, 1993;Caplehorn et al, 1996;Caplehorn & Drummer, 1999;Hser et al, 2001;Gibson et al, 2008;Davstad et al, 2009) and to be associated with an immunosuppressive (Pillai et al, 1991;McCarthy et al, 2001;Li et al, 2002;Suzuki et al, 2002;Cabral, 2006) state that includes a compensatory immunostimulation (Reece, 2007a(Reece, , 2007b(Reece, , 2007c(Reece, , 2007d, which may mollify with time (Novick et al, 1989;Ochshorn et al, 1989) to suppress cell replication (Zagon et al, 2002) and likely stem cell division (Reece & Davidson, 2007) and particularly affects the brain (Eisch & Harburg, 2006;Canales, 2007;Drake et al, 2007;Kolodziej et al, 2008). Addiction to various drugs including opiates has also been shown to be associated with a number of other changes such as osteoporosis (Kim et al, 2006), hair graying (Reece, 2007b), neuropsychiatric deficits (Dyer & White, 1997;Galarneau et al, 2006;Reece, 2008aReece, , 2008bReece, , 2008cSchreiber et al, 2008), and dental abnormalities (Carter, 1978;Fan et al, 2006;Reece, 2007aReece, , 2007bReec...…”

Section: Introductionmentioning

confidence: 99%

“…The present report has been prepared as part of a series of reports of a clinical audit of the NIT experience of this clinic (Reece, 2007a(Reece, , 2007b(Reece, , 2007c(Reece, , 2007d and as a companion article to another from this clinic related to absolute and standardized relative mortality rates to address these gaps in the literature. The study is structured as a naturalistic clinical audit and so does not have the advantages conferred by randomization.…”

Section: Introductionmentioning

confidence: 99%

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Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine

Reece

2009

Journal of Substance Abuse Treatment

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine

Reece

2009

Journal of Substance Abuse Treatment

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“…Addiction has also been shown to be associated with various other disorders which are frequently associated with age-related degenerative change including osteoporosis, 15 neuropsychiatric co-morbidity 16 and suppression of neurogenesis by opiates, 17 cannabinoids, alcohol and stimulants, dilutional anaemia, 18,19 reduced sperm counts, 20,21 accelerated hair greying, 22 and coronary calcification. 23 Furthermore, addicts of all kinds are well known to have a high mortality.…”

Section: Introductionmentioning

confidence: 99%

Dentition of addiction in Queensland: poor dental status and major contributing drugs

Reece¹

2007

Australian Dental Journal

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Background: Although it is said that drug addiction is associated with poor dental health, there is little research in this area. In particular, there is little work comparing the effects of the different drugs of addiction. Methods: A cross-sectional patient survey of dental health was undertaken in a family practice comparing opiate and other drug addicts (DA) with non-addicts (NA). The age range was restricted to 19-45 years. Damaged teeth were counted and a semi-quantitative score applied to severity to allow the calculation of an overall dental index. A medical review only was undertaken; recognized dental diagnostic criteria were not applied. Results: There were 233 and 47 respondents in the DA and NA groups, respectively. The mean ages and gender ratios were similar in both groups. DA used more addictive drugs than NA (all P<0.001). DA had more absent, traumatized, major cavitated and extracted teeth (all P<0.05). Addicts had a worse severity index (P<0.02) and dental index (13.13±24.00 vs. 4.74±16.03; P<0.005). Furthermore, dental pathology developed in DA at younger ages than in NA with 56.8% vs. 5.4% of patients younger than 38 years having dental indices more than 10 respectively (OR = 22.98, 95% CI = 5.57-200.65, P<0.0000001). At multivariate analysis age, gender, and dose and/or duration of tobacco, methadone, morphine, and alcohol were significantly associated with these pathologies. Conclusion: These data are consistent with published dental reports and basic science information that drug addiction has a deleterious effect on dental health, that in addiction this effect is rapid and severe, and that tobacco, methadone, morphine and alcohol contribute importantly to these changes.

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“…Smoking was reported to be significantly associated with hair greying, and impairment of stem cell regenerative capacity with substance abuse was postulated to lead to greying of hair [31,32].…”

Section: Aetiopathogenesismentioning

confidence: 99%

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

Nigam¹,

Nigam²

2017

Pigmentary Disorders

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Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greying is a feature in a number of well recognised syndromes. A number of other conditions have also been observed to be associated with premature greying of hair.

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Hair Graying in Substance Addiction

Cited by 40 publications

References 6 publications

Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine

Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine

Dentition of addiction in Queensland: poor dental status and major contributing drugs

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

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