Haematological profile of dengue fever

Tahlan, Anita; Bhattacharya, Amrita

doi:10.18203/2320-6012.ijrms20175456

Cited by 12 publications

(17 citation statements)

References 5 publications

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“…We found thrombocytopenia to be the most important abnormality which correlated well with findings of Patel K et al [12]. and Tahlan A et al [13] . Decrease in platelet occurs due to depression of bone marrow or direct infection of the megakaryocytes by virus leading to increased destruction of the platelets or the presence of antibodies directed against the platelets [9] .…”

Section: Discussionsupporting

confidence: 92%

Hematological parameters and aminotransferase changes in dengue infection

Saara¹,

Kudchi²,

Begum³

2019

Int. J. Clin. Diagn. Pathol.

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Background: Dengue is a viral disease that is caused by dengue virus. The incidence of dengue has rapidly increased over the last few years. Classical dengue fever presents as fever, generalized body ache, myalgia, arthralgia, and headache. The hematological parameters such as hemoglobin (Hb), hematocrit (Hct), WBC count, differential WBC counts and platelet count vary each day of the fever in dengue patients. This study was undertaken to study the various hematological parameters and aminotransferases and their correlation with severity of dengue. Methods: Descriptive study of 100 patients admitted in KBNTGH, Kalaburagi was carried out to evaluate the hematological parameters and changes in aminotransferase levels. Results: 58 were male and 42 were female and the age ranged between 1yr-75yr. The haemoglobin was found to be decreased in 28% of the cases, whereas in 19% of the cases hematocrit was found to be increased. 52% of the cases had a decreased leucocyte count and 66% showed increased lymphocyte percentage. Decrease in platelet count was seen in 87 cases. 85 showed increased AST levels and 67 showed increased ALT levels. Conclusion:Dengue is a self-limiting disease. Peripheral blood parameters are very helpful for disease monitoring and can be useful in prediction of prognosis. Liver involvement is also seen and is related to severity of dengue. These indicators, if rightly and timely assessed can be of value for better care of complicated cases

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Section: Discussionsupporting

confidence: 92%

Hematological parameters and aminotransferase changes in dengue infection

Saara¹,

Kudchi²,

Begum³

2019

Int. J. Clin. Diagn. Pathol.

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“…This was similar to study done by Shekar et al in which thrombocytopenia was seen in 61% cases 10 . While in studies done by Gajera et al and Tahlan A et al platelet count <1 lakh/ mm 3 was seen in 81% and 67.39% cases respectively 12,14 .…”

Section: Hematological Profilementioning

confidence: 83%

Evaluation of Hematological and Biochemical Profile of Early Dengue Patients

Gitika¹,

Garg²,

Gill³

2018

IJCMR

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Introduction: Dengue infection has been identified as the fastest spreading mosquito-borne viral disease by World Health Organization. This study is an attempt to elucidate the positive laboratory profile of serologically diagnosed early dengue patients so as to facilitate early diagnosis, treatment and management. Material and methods: A total of 100 cases diagnosed as dengue based on rapid immunological card tests (NS1 antigen and Ig M antibodies) were analyzed for haematological and biochemical parameters. Haematological parameters included haemoglobin, hematocrit, TLC, DLC, platelets count and peripheral blood smear. Biochemical parameters including serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin (T. Bil.) and Alkaline phosphatase (ALP). Result: Haemoglobin ranged from 6.4-17.0 gm/dl. Hematocrit was raised in 06 (06%) cases. Thrombocytopenia (Platelets count <1lakh/mm 3) was seen in 54 (54%) cases. TLC <4,000/ mm 3 was seen in 43 (43%) cases and >11,000/mm 3 was seen in 09 (09%) cases. Lymphocytosis and neutrophilia were seen in 40 (40%) and 14 (14%) cases respectively. On peripheral blood smear reactive and plasmacytoid lymphocytes seen. AST, ALT, ALP and Bilirubin were deranged in 64 (64%), 60(60%), 12(12%) and 02(02%) cases respectively. Conclusion: Haemoconcentration, leucopenia, thrombocytopenia, lymphocytosis, and raised liver enzymes SGOT and SGPT along with reactive/ plasmacytoid lymphocytes on peripheral smear gives enough clues to test for dengue serology so that dengue cases can be diagnosed in their initial stages and prompt management can be started to prevent complications of dengue fever.

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“…It is a WHO criteria for DHF. 8,11,17 Cause for thrombocytopenia includes Platelet consumption, activation by surface band C3 + Ig G with complement moderated lysis, peripheral sequestration, destruction due to antibodies against viral antigens on platelets and direct damage to megakaryocyte precursors with decreased production 1,4,5,11,14,17 .…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Dengue needs to be diagnosed early as there is no specific therapy. 3,4 Clinical features are of limited utility in diagnosing impending rapidly developing severe dengue and have to be supplemented by certain lab tests for accurate and early diagnosis of progression. [2][3][4][5][6][7] Severe dengue is characterized by thrombocytopenia (<1 lakh/cumm) preceding rise in hemocrit.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Clinical features are of limited utility in diagnosing impending rapidly developing severe dengue and have to be supplemented by certain lab tests for accurate and early diagnosis of progression. [2][3][4][5][6][7] Severe dengue is characterized by thrombocytopenia (<1 lakh/cumm) preceding rise in hemocrit. 2,3,6,7 Thrombocytopenia is a consistent feature in dengue and a major reason for hospitalisation due to the risk of bleeding.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do the small blood cells have a big impact as prognosticators in dengue – A study

Joshi¹,

Divyashree²,

Tanjore³

et al. 2020

JDPO

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Dengue is an arboviral disease endemic in India. Severe dengue has a high morbidity. The progression to severe dengue may be diagnosed by clinical and lab parameters, are of the useful lab tests is platelet count, as thrombocytopenia is a consistent feature in dengue. There is confusion about the role thrombocytopenia in dengue. Our study aims to study the platelet count patterns and its relevance to severity of dengue. Materials and Methods: We conducted a study on 132 dengue positive cases with relevant hematology data in November 2016. Results: We had predominance of young people and males in the study group. Thrombocytopenia was uniform across the ages and sexes. Severe thrombocytopenia constituted 56%, had significant association with atypical lymphocytosis, rise in hematocrit and antibody patterns. Conclusion: Platelet counts are marker of dengue, can serve as predicators of severity, platelet count monitoring helps guide transfusion therapy.

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Haematological profile of dengue fever

Cited by 12 publications

References 5 publications

Hematological parameters and aminotransferase changes in dengue infection

Hematological parameters and aminotransferase changes in dengue infection

Evaluation of Hematological and Biochemical Profile of Early Dengue Patients

Do the small blood cells have a big impact as prognosticators in dengue – A study

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