Habitual physical exercise has beneficial effects on telomere length in postmenopausal women

Kim, Jung‐Ha; Ko, Jae‐Hong; Lee, Duk Chul; Lim, Inja; Bang, Hyoweon

doi:10.1097/gme.0b013e3182503e97

Cited by 49 publications

(51 citation statements)

References 53 publications

(48 reference statements)

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“…Given the observed shifts in substrate oxidation in the present study with a relatively small sample size, it would be of interest to investigate the manipulation of CHOs in pre-exercise feeding in addition to supplementation during exercise. It is yet to be determined what effect this would have on self-selected exercise, however the current study looked to replicate recommended habitual submaximal fixed-duration exercise in females [54].…”

Section: Discussionmentioning

confidence: 99%

Effect of Galactose Ingestion Before and During Exercise on Substrate Oxidation, Postexercise Satiety, and Subsequent Energy Intake in Females

Duckworth

Backhouse

O’Hara

et al. 2015

Journal of the American College of Nutrition

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Abbreviations CHO = carbohydrate, GLU = glucose, GAL = galactose, PLA = placebo, GI = glycemic index, FFA = free fatty acid, EE = energy expenditure, TEE = total energy expenditure, AUC = area under the curve. 2 AbstractObjective: To examine the effects of consuming a galactose carbohydrate (CHO) drink on substrate oxidation, post-exercise satiety and subsequent energy intake. Methods:Nine recreationally active eumenorrheic females undertook three trials, each consisting of running for 60-minutes at 65% VO 2peak followed immediately by a 90-minute rest period. Prior to (300 ml) and at every 15 minutes during exercise (150 ml), participants consumed either a glucose (GLU: GI 89) or galactose (GAL: GI 20) drink each containing 45g of CHO, or an artificially-sweetened placebo (PLA). Following the rest period, participants were provided with an ad-libitum test lunch and asked to record food intake for the remainder of the day.Results: Plasma glucose was significantly greater throughout exercise and rest following the GLU trial compared with the GAL and PLA trials (P<0.05), however there were no differences in CHO oxidation. Hunger was significantly lower (P<0.05) throughout the GAL compared to the GLU and PLA trials. There were no significant differences between trials for energy intake during the post-exercise meal. Overall net energy balance for the 24-hours was negative in both the GAL (-162±115 kcal; P<0.05 vs. GLU) and PLA trials (-49±160 kcal). Conclusions:Results demonstrate that ingesting a solution containing galactose before and during exercise can positively impact post-exercise satiety and energy balance throughout the day, compared to a more readily available and widely consumed form of CHO. Despite this, there appears to be no apparent benefit in consuming a CHO beverage on fuel utilization for this moderate exercise intensity and duration.

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Section: Discussionmentioning

confidence: 99%

Effect of Galactose Ingestion Before and During Exercise on Substrate Oxidation, Postexercise Satiety, and Subsequent Energy Intake in Females

Duckworth

Backhouse

O’Hara

et al. 2015

Journal of the American College of Nutrition

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“…No total dos discursos analisados chama a atenção o fato de que as opiniões sobre o envelhecimento e saúde estão quase sempre articuladas, conforme é possível verificar na Sobre a questão do antienvelhecimento, estudos têm argumentado sobre os efeitos positivos do exercício associados à preservação do tamanho dos telômeros, à função da telomerase e à produção de respostas antiinflamatórias em seres humanos (Cherkas et al, 2008;Kim, Ko, Lee, & Bang, 2012 Segundo Moreira & Nogueira (2008), a experiência de envelhecer também é subjetiva, ou seja, ela é vivida no mundo de forma ambígua, com seus aspectos negativos e positivos. Apesar dela se entrelaçar a valores socioculturais que preconizam o belo, o novo, o produtivo, no caso das Hebes contemporâneas o exercício físico é apontado como recurso utilizado para construir um envelhecimento resignificado, ao menos no que diz respeito à estética e à produtividade.…”

Section: Discussionunclassified

Health, physical exercise and fear of aging: anti-aging problematizations in amateur bodybuilders speeches

Teixeira¹,

Caminha²

2017

motricidade

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ARTIGO ORIGINAL | ORIGINAL ARTICLE RESUMOArgumentos científicos favoráveis à aplicação do exercício físico como intervenção sobre "envelhecimento" insistem em se apoiar num conceito de saúde biológico. Considerando a hegemonia desse discurso na Educação Física, questiona-se em que medida deve-se aceitar que a relação saúde/envelhecimento permaneça resumida à mera busca pela manutenção de capacidades fisiológicas? O objetivo foi analisar as problematizações produzidas sobre a relação saúde e exercício físico por um grupo de mulheres fisicamente ativas da cidade do Recife, Pernambuco-Brasil, tendo como cenário suas opiniões sobre o processo de envelhecimento. Quarenta e cinco fisiculturistas amadoras foram selecionadas a partir da técnica snowball sample. Elas responderam individualmente um roteiro de entrevista com imagens seguindo a técnica photo elicitation. Utilizou-se a análise de discurso proposta por Foucault. Verificou-se que o grupo compreende a relação saúde/envelhecimento como forma de construir identidades, ultrapassando a visão negativa da velhice como processo negativo vital. O medo de envelhecer denota a presença de autocontrole centrado nas práticas de saúde ao longo da vida. O exercício físico exerce um papel que transcende o mero controle de variáveis biológicas, sendo um recurso para fortalecer a experiência de se ver e se sentir mais jovem. Palavras-chave: Saúde, exercício físico, medo de envelhecer, discursos, mulheres, fisiculturistas. ABSTRACTScientific arguments in favour of applying physical exercise as an intervention on "aging" insists on relying on the biological concept of health. Considering the hegemony of this concept in physical education, the present study questions in what extent it must be accepted that the relationship between health/aging remains summarized in the mere search for maintaining physiological capabilities? The aim was to analyse the problematizations on the relationship between health and exercise in a group of physically active women from the city of Recife, Pernambuco, Brazil, in the context of aging process. Forty-five amateur bodybuilders were selected utilizing the sample snowball technique. They answered an interview guide with pictures according to the photo elicitation technique, individually. It was utilized the speech analysis proposed by Foucault. The group understands the relationship health/aging as a way to build identities, overcoming the negative perception of old age as vital and negative process. The fear of aging denotes the presence of self-centred healthcare practices carried over the years. Physical exercise plays a role that transcends the mere control of biological variables, being a resource to strengthen the experience to look and feel younger.

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“…34,35). In addition, metabolic biochemical stress, such as states of insulin resistance or low adiponectin, is associated with shorter telomere length (36,37). Targeting the comorbidity between psychologic stress and metabolic stress might be more powerful than reducing them individually, as they are often interdependent (31).…”

Section: Reducing Biochemical Stressmentioning

confidence: 99%

“…Exercise may be one of the important factors shaping apparent or actual lengthening, as it is related to greater numbers of na€ ve cells as well as longer telomere length (36,46). Increasing well-being through dampening stress and concomitant increases in growth and restorative factors might induce a specific pattern of adhesion molecule-stimulated trafficking patterns and result in cells with longer telomeres-either more na€ ve cells or fewer senescent cells.…”

Section: Increases In "Younger" Cellsmentioning

confidence: 99%

How “Reversible” Is Telomeric Aging?

Epel

2012

Cancer Prevention Research

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A critical question in human health is the malleability of telomere length. Telomere length, sampled at one point during adult life, is predictive of certain types of cancer and other immune and metabolicrelated diseases. We now know from basic studies that the telomere/telomerase maintenance system plays a causal role in accelerating biologic aging and promoting disease processes. One can develop short telomeres for a multitude of reasons. Historical factors such as genetics, prenatal conditions, and early adversity, contribute to adult telomere length; however, current stress and lifestyle are also associated. If these modifiable predictors are causal factors in telomere shortening, there is a tremendous opportunity to improve maintenance and possibly even lengthen telomeres with behavioral interventions. This minireview discusses our current understanding of telomere lengthening and questions facing the field. Several small-scale stress reduction/wellness studies show promising findings, suggesting that cell aging can be slowed or reversed in vivo over short periods. Moreover, possible mechanisms are discussed, that take into account actual telomeric lengthening, such as that which occurs through telomerase-mediated elongation, or mechanisms resulting in "pseudo-telomeric lengthening" as might occur from changes in cell type distribution. There is a strong need for more translational clinical to bench research to address mechanistic questions in experimental models. In addition, well-designed intervention research that examines both telomeres and potential mediators of change can further enhance our understanding of malleability, mechanism, and clinical implications of telomere lengthening. Cancer Prev Res; 5(10); 1163-8. Ó2012 AACR.A rapidly growing body of research suggests that one snapshot measure of leukocyte telomere length is predictive of age-related physiologic decline, onset of diseases of aging, such as cancer and dementia, and early mortality (1-3). Thus, it is not surprising that when people learn about telomeres, one of the most common questions is "Can telomeres be lengthened?" The answer is not so simple. While the quick answer is "yes," it is one that requires qualification and explanation. Here, we review what is known so far about telomere lengthening in humans, with respect to stress reduction interventions in particular, and address important questions to understand the mechanisms of apparent telomere lengthening. Telomeres Shorten . . . and LengthenTelomeres tend to shorten slowly over years of aging but are active and dynamic, especially when examined over short periods. In the early studies of telomeres in single-celled organisms called protozoa, Blackburn and Greider observed, "telomeres are dynamic structures in vivo, being acted on by shortening and lengthening activities" (4). They discovered telomerase, an intracellular enzyme that has an RNA reverse transcriptase component that lengthens telomeres. Telomerase-mediated elongation of telomeres occurs through de novo synthes...

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Habitual physical exercise has beneficial effects on telomere length in postmenopausal women

Abstract: Habitual physical exercise is associated with greater telomere length in postmenopausal women. This finding suggests that habitual physical exercise in postmenopausal women may reduce telomere attrition.

Cited by 49 publications

References 53 publications

Effect of Galactose Ingestion Before and During Exercise on Substrate Oxidation, Postexercise Satiety, and Subsequent Energy Intake in Females

Effect of Galactose Ingestion Before and During Exercise on Substrate Oxidation, Postexercise Satiety, and Subsequent Energy Intake in Females

Health, physical exercise and fear of aging: anti-aging problematizations in amateur bodybuilders speeches

How “Reversible” Is Telomeric Aging?

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