H1N1 pneumonia: our experience in 50 patients with a severe clinical course of novel swine-origin influenza A (H1N1) virus (S-OIV)

Valente, Tullio; Lassandro, Francesco; Marino, Maurizio; Squillante, Francesco; Aliperta, M.; Muto, R.

doi:10.1007/s11547-011-0734-1

Cited by 25 publications

(28 citation statements)

References 38 publications

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“…Autopsies show that diffuse alveolar damage, intra-alveolar edema and cellular infiltration are some of the major histopathological findings [2,38–42], which are consistent with the findings in this study. Excessive infiltration of immune cells and injury to the lung parenchyma can compromise gaseous exchange by reducing lung volume and compliance [43].…”

Section: Discussionsupporting

confidence: 91%

Peptide Targeting and Imaging of Damaged Lung Tissue in Influenza-Infected Mice

Thévenin

et al. 2013

Future Microbiol.

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Aim In this study, we investigate whether pH (low) insertion peptide (pHLIP) can target regions of lung injury associated with influenza infection. Materials & methods Fluorophore-conjugated pHLIP was injected intraperitoneally into mice infected with a sublethal dose of H1N1 influenza and visualized histologically. Results pHLIP specifically targeted inflamed lung tissues of infected mice in the later stages of disease and at sites where alveolar type I and type II cells were depleted. Regions of pHLIP-targeted lung tissue were devoid of peroxiredoxin 6, the lung-abundant antioxidant enzyme, and were deficient in pneumocytes. Interestingly, a pHLIP variant possessing mutations that render it insensitive to pH changes was also able to target damaged lung tissue. Conclusion pHLIP holds potential for delivering therapeutics for lung injury during influenza infection. Furthermore, there may be more than one mechanism that enables pHLIP variants to target inflamed lung tissue.

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Section: Discussionsupporting

confidence: 91%

Peptide Targeting and Imaging of Damaged Lung Tissue in Influenza-Infected Mice

Thévenin

et al. 2013

Future Microbiol.

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“…D. A scan obtained at d 97 of illness showed residual subpleural fibrosis in both lower lung lobes. possibly with superimposed secondary bacterial infection at its progressive stage [17]. In our study, superimposed bacterial or fungal infection of the respiratory tract was observed in 3 patients.…”

Section: Discussionsupporting

confidence: 45%

Longitudinal changes of pneumonia complicating novel influenza A (H1N1) by high-resolution computed tomography

Feng

Xia

Shi

et al. 2015

Radiology of Infectious Diseases

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Available online ▪ ▪ ▪ AbstractPurpose: To assess lung lesions in patients with pneumonia complicating novel influenza A (H1N1) by serial high-resolution computed tomography (HRCT) during the early, progressive and convalescent stages. Samples and methods: Serial HRCT scans in 39 patients with pneumonia complicating novel influenza A (H1N1) were reviewed for predominant patterns of lung abnormalities as well as distribution and extent of involvement. Longitudinal changes were assessed at different time points. Results: In the early stage, the most common HRCT finding was patchy ground-glass opacity (GGO) (n ¼ 4, 54.7%). In the progressive stage, bilaterally distributed GGO mixed with consolidation was the most commonly observed feature (n ¼ 28, 71.8%). The diffuse pattern deteriorated to a peak (n ¼ 17, 43.6%) at this stage. In the convalescent stage, the most common finding was fibrosis (n ¼ 25, 64.1%). Averagely, fibrosis was observed at d 18.5 ± 6.4 after the onset of symptoms. Three patterns of longitudinal changes of the lesions were observed, including: type 1, improvement after deterioration; type 2, concurrent improvement and deterioration followed by improvement; and type 3, gradual improvement. Type 1 was the more common pattern (n ¼ 27, 69.2%). Complete serial HRCT scans from initial and final scan were obtained in 24 patients, and the mean CT score peaked at d 8e14 of the illness. Conclusion: HRCT may play a role in detecting and characterizing pulmonary lesions for the cases of pneumonia complicating influenza A. In addition, it may contribute to monitoring longitudinal changes of pneumonia and assessing therapeutic response.

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“…Generally, the lung findings first appeared in the lower zones and then rapidly progressed to the middle and upper zones, and the patchy areas progressed to consolidation. Valente et al (21) reported the reversed halo sign for the first time in H1N1 pneumonia. The reports related to the radiological findings of novel influenza A (H1N1) in children are fewer, but most children demonstrated almost similar radiological findings observed in adults (3-7).…”

Section: Discussionmentioning

confidence: 94%

“…In the study of Teplisky et al (5), which included only CXR examinations in 47 patients, consolidation and GGO had a significantly higher frequency in patients who needed more days of oxygen supplement, and initial CXR with lobar consolidation was observed in patients with a greater risk of intensive care unit admission. Valente et al (21) reported 50 patients with a severe clinical course of novel swine-origin influenza A (H1N1) virus (S-OIV) and found that lesion extent is related to aggressiveness of the illness and that the clinical course is worse in obese patients and that superinfection leads to worsening of clinical conditions. Lopez Delgado et al (25) found thrombocytopenia as a mortality risk factor.…”

Section: Discussionmentioning

confidence: 99%