Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

4
109
1

Year Published

2003
2003
2023
2023

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 103 publications
(114 citation statements)
references
References 35 publications
4
109
1
Order By: Relevance
“…The opposite effect in Na þ -containing media can be interpreted as an activation of the Na þ /H þ exchange responsible for maintenance of the proton motive force. 31 We confirmed a direct coupling between Na þ /H þ and hPepT1 by showing that Na þ -dependence was not observed in hPepT1-mediated di-and tripeptide transport at pH 5.2. We showed by RT-PCR (Figure 3e) that NHE1, NHE2 and, to a lesser extent, NHE3 are expressed in KG-1 cells.…”
Section: The Monocytic Kg-1 Cell Line Expresses a Functional Hpept1 Tsupporting
confidence: 75%
“…The opposite effect in Na þ -containing media can be interpreted as an activation of the Na þ /H þ exchange responsible for maintenance of the proton motive force. 31 We confirmed a direct coupling between Na þ /H þ and hPepT1 by showing that Na þ -dependence was not observed in hPepT1-mediated di-and tripeptide transport at pH 5.2. We showed by RT-PCR (Figure 3e) that NHE1, NHE2 and, to a lesser extent, NHE3 are expressed in KG-1 cells.…”
Section: The Monocytic Kg-1 Cell Line Expresses a Functional Hpept1 Tsupporting
confidence: 75%
“…What has been less clear is why transport via endogenous H ϩ -oligopeptide symporters exhibits variable dependence upon extracellular sodium, whereas studies using recombinant transporters expressed exogenously indicate that sodium is not required for H ϩ gradient-driven dipeptide uptake (12,39). A recent series of elegant experiments has demonstrated that the apparent sodium dependence of the endogenous symporter activity in Caco-2 tissue culture cells is due to a functional coupling between Na ϩ /H ϩ exchange and oligopeptide uptake (40,41), and that this coupling occurs specifically with an exchanger located on the apical membrane (14). The importance of our work in relation to the previously established findings lies in the fact that we have shown that functional coupling likely occurs in live animals as well as in isolated cell systems with dramatic physiological consequences.…”
Section: Discussionmentioning
confidence: 99%
“…A component of the ileal villus cell BBM, the Na ϩ /H ϩ exchanger NHE3, was also found to be partially associated with lipid rafts (20) and its activity and trafficking is lipid raft dependent (28). A functional coupling between hPepT1 and NHE3 has previously been shown (44). It is therefore reasonable to hypothesize that hPepT1 could also be present in lipid rafts.…”
mentioning
confidence: 85%