Gyrate Atrophy of the Choroid and Retina

Gyrate Atrophy of the Choroid and Retina Diagnosed in Adulthood With a Homozygous OAT Variant: A Case Report Highlighting the Need for Long‐Term Care

“…Furthermore, even among patients who initially respond favorably, the long‐term visual prognosis remains uncertain. Based on such findings, some studies have concluded that diet therapy alone may not be effective in altering disease progression [ 21 ] [ 22 ].…”

Gyrate Atrophy of the Choroid and Retina Diagnosed in Adulthood With a Homozygous OAT Variant: A Case Report Highlighting the Need for Long‐Term Care

“…Furthermore, even among patients who initially respond favorably, the long‐term visual prognosis remains uncertain. Based on such findings, some studies have concluded that diet therapy alone may not be effective in altering disease progression [ 21 ] [ 22 ].…”

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study

“…Several small previous published reports suggest that current therapeutic strategies can potentially play a role in slowing down disease progression, although they do not prevent the development of severe visual impairment. Previous studies have shown a possible beneficial effect of early initiation of a natural protein‐restricted diet on the progression of chorioretinal atrophy [ 12 , 13 ]. Our study provides additional indications of a beneficial effect of a natural protein‐restricted diet in a subset of patients who started dietary therapy at a young age.…”

Clinical characteristics of gyrate atrophy compared with a gyrate atrophy-like retinal phenotype

“…A long-term adherence to this diet can, however, be challenging. 24 Figure 3. Comparison of typical wide-angle colour image, optical coherence tomography (OCT) and fundus autofluorescence images of gyrate atrophy (GA, top) and a gyrate atrophy-like retinal phenotype (GALRP, bottom).…”

Gyrate Atrophy of the Choroid and Retina Diagnosed in Adulthood With a Homozygous OAT Variant: A Case Report Highlighting the Need for Long‐Term Care

“…Furthermore, even among patients who initially respond favorably, the long‐term visual prognosis remains uncertain. Based on such findings, some studies have concluded that diet therapy alone may not be effective in altering disease progression [ 21 ] [ 22 ].…”

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study

“…Several small previous published reports suggest that current therapeutic strategies can potentially play a role in slowing down disease progression, although they do not prevent the development of severe visual impairment. Previous studies have shown a possible beneficial effect of early initiation of a natural protein‐restricted diet on the progression of chorioretinal atrophy [ 12 , 13 ]. Our study provides additional indications of a beneficial effect of a natural protein‐restricted diet in a subset of patients who started dietary therapy at a young age.…”

Clinical characteristics of gyrate atrophy compared with a gyrate atrophy-like retinal phenotype

“…A long-term adherence to this diet can, however, be challenging. 24 Figure 3. Comparison of typical wide-angle colour image, optical coherence tomography (OCT) and fundus autofluorescence images of gyrate atrophy (GA, top) and a gyrate atrophy-like retinal phenotype (GALRP, bottom).…”

Gyrate Atrophy of the Choroid and Retina Diagnosed in Adulthood With a Homozygous OAT Variant: A Case Report Highlighting the Need for Long‐Term Care

“…Furthermore, even among patients who initially respond favorably, the long‐term visual prognosis remains uncertain. Based on such findings, some studies have concluded that diet therapy alone may not be effective in altering disease progression [ 21 ] [ 22 ].…”

Novel Insights Into Gyrate Atrophy of the Choroid and Retina (GACR): A Cohort Study

“…Several small previous published reports suggest that current therapeutic strategies can potentially play a role in slowing down disease progression, although they do not prevent the development of severe visual impairment. Previous studies have shown a possible beneficial effect of early initiation of a natural protein‐restricted diet on the progression of chorioretinal atrophy [ 12 , 13 ]. Our study provides additional indications of a beneficial effect of a natural protein‐restricted diet in a subset of patients who started dietary therapy at a young age.…”

Clinical characteristics of gyrate atrophy compared with a gyrate atrophy-like retinal phenotype

“…A long-term adherence to this diet can, however, be challenging. 24 Figure 3. Comparison of typical wide-angle colour image, optical coherence tomography (OCT) and fundus autofluorescence images of gyrate atrophy (GA, top) and a gyrate atrophy-like retinal phenotype (GALRP, bottom).…”