Guttate leukoderma in Darier's disease

Cornelison, R. L.

doi:10.1001/archderm.102.4.447

Cited by 9 publications

(3 citation statements)

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“…Some have solely hypopigmented macules and only subsequently develop more characteristic keratotic papules on the trunk 4,6 . Other individuals have hypopigmented macules on the chest and abdomen present concurrently with greasy, keratotic papules on the scalp and seborrheic areas of the face and trunk 1–3,5 , 7 . The changes associated with Darier's disease, including nail notching and verrucous papules on the dorsal aspect of the hands, have been observed with this variant 2,4–6 .…”

Section: Discussionmentioning

confidence: 96%

“…1 These hypopigmented macules are present in a perifollicular distribution on the neck, trunk, arms, and thighs and have been described as guttate leukoderma in Darier's disease. 2 Originally regarded as postin¯ammatory hypopigmentation, these lesions were later recognized as an early or subclinical form of this acantholytic disorder. 3,4 Histologically, these macules most commonly have a decrease in melanin in the basal layer.…”

Section: Discussionmentioning

confidence: 99%

“…Although Darier's disease was originally described in 1889, this variant characterized by hypopigmented macules in dark‐skinned individuals was first recognized by Goodall and Richmond in 1965 1 . These hypopigmented macules are present in a perifollicular distribution on the neck, trunk, arms, and thighs and have been described as guttate leukoderma in Darier's disease 2 . Originally regarded as postinflammatory hypopigmentation, these lesions were later recognized as an early or subclinical form of this acantholytic disorder 3,4 …”

Section: Discussionmentioning

confidence: 99%

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A unique variant of Darier's disease

Peterson¹,

Lesher²,

Sangüeza³

2001

Int J Dermatology

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A 45-year-old black woman presented with a chief complaint of an increasing number of "light spots" on her face, upper trunk, and legs. She had a 4-year history of a pruritic eruption on the dorsum of her hands. The eruption was particularly pruritic in the summer months. Other family members, including her sister and her daughters, reportedly had a similar dermatologic problem. The patient had been previously evaluated and biopsied by another dermatologist. The earlier biopsy was nondiagnostic, however, and she presented for further evaluation of this problem. On physical examination, the patient had hypopigmented macules along her jawline (Fig. 1), lateral neck, and upper chest. She had similar hypopigmented macules on her thighs. She had hyperkeratosis of the palmoplantar surface of her hands and feet. The dorsum of her hands had numerous coalescing, shiny, flat-topped, hypopigmented papules (Fig. 2), and several of her fingernails had distal, V-shaped notching. A punch biopsy from a papule on the dorsum of her hand was obtained. The epidermis had corps ronds present with focal areas of acantholysis above the basal layer (Fig. 3). The dermis had sparse, superficial, perivascular infiltrates composed of lymphocytes and histiocytes. These changes were consistent with our clinical diagnosis of Darier's disease (keratosis follicularis).

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