Gut Microbiota: A Key Factor in the Host Health Effects Induced by Pesticide Exposure?

Meng, Zhiyuan; Liu, Li; Yan, Sen; Sun, Wei; Jia, Ming; Tian, Sinuo; Huang, Shan; Zhou, Zhiqiang; Zhu, Wentao

doi:10.1021/acs.jafc.0c04678

Cited by 48 publications

(31 citation statements)

References 161 publications

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Section: The Interaction Of Gut Microbiota and Environmental Hazardsmentioning

confidence: 99%

“…Atrazine, another widely used pesticide, is metabolized by rare gut bacteria Serratiamarcescens and Pseudomonas protegens, causing functional and inherited changes in the gut microbiota (Wang et al, 2020). Thus, from the perspective of Meng et al, the gut microbiota is a key factor in the host health effects induced by pesticides (Meng et al, 2020). Similarly, Chiu et al reviewed the impact of environmental chemicals on gut microbiota and suggested that pesticide exploration contributes to alterations in the composition, gene expression, function, and health effects in the host, including metabolism, immunity, and neurological function (Chiu et al, 2020).…”

Section: Chemical Factorsmentioning

confidence: 99%

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Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

Huang

2022

Front. Cell. Infect. Microbiol.

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Insulin resistance is a hallmark of Alzheimer’s disease (AD), type II diabetes (T2D), and Parkinson’s disease (PD). Emerging evidence indicates that these disorders are typically characterized by alterations in the gut microbiota composition, diversity, and their metabolites. Currently, it is understood that environmental hazards including ionizing radiation, toxic heavy metals, pesticides, particle matter, and polycyclic aromatic hydrocarbons are capable of interacting with gut microbiota and have a non-beneficial health effect. Based on the current study, we propose the hypothesis of “gut microenvironment baseline drift”. According to this “baseline drift” theory, gut microbiota is a temporarily combined cluster of species sharing the same environmental stresses for a short period, which would change quickly under the influence of different environmental factors. This indicates that the microbial species in the gut do not have a long-term relationship; any split, division, or recombination may occur in different environments. Nonetheless, the “baseline drift” theory considers the critical role of the response of the whole gut microbiome. Undoubtedly, this hypothesis implies that the gut microbiota response is not merely a “cross junction” switch; in contrast, the human health or disease is a result of a rich palette of gut-microbiota-driven multiple-pathway responses. In summary, environmental factors, including hazardous and normal factors, are critical to the biological impact of the gut microbiota responses and the dual effect of the gut microbiota on the regulation of biological functions. Novel appreciation of the role of gut microbiota and environmental hazards in the insulin resistance would shed new light on insulin resistance and also promote the development of new research direction and new overcoming strategies for patients.

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Section: The Interaction Of Gut Microbiota and Environmental Hazardsmentioning

confidence: 99%

Section: Chemical Factorsmentioning

confidence: 99%

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

Huang

2022

Front. Cell. Infect. Microbiol.

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“…The emerging exploration of the association between pesticides and the host's gut microbiota has completely changed the traditional understanding of pesticide-induced health effects of the host [36,37]. Several studies have proved the close association between gut microbiota and MetS [40][41][42].…”

Section: Low-dose Chi Disrupted Gut Microbiota Of Micementioning

confidence: 99%

“…Furthermore, the microbiota induced the in ammation of adipose tissue and increased the expression levels of genes responsible for fatty acid uptake in an FXR-dependent manner [34]. In particular, several studies have reported that pesticide exposure can disrupt the gut microbiota of the host [36,37]. Among them, few studies have suggested that the gut microbiota plays an important role in the pesticides' effects on host health [4,38].…”

Section: Introductionmentioning

confidence: 99%

Chlorothalonil induces metabolic syndrome in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways

Meng

Yan

Sun

et al. 2021

Preprint

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Background：The most commonly used organochlorine pesticide, chlorothalonil (CHI), is ubiquitous in a natural environment and poses many adverse effects to organisms. Unfortunately, the toxicity mechanisms of CHI have not been clarified yet.Results: This study found that the low-dose CHI based on acceptable daily intake (ADI) level could induce metabolic syndrome (MetS) in mice, including obesity, hepatic steatosis, dyslipidemia, and insulin resistance. In addition, exposure to low-dose CHI could induce an imbalance in the gut microbiota of mice, resulting in a significant increase in the ratio of Firmicutes to Bacteroidetes. Furthermore, the results of the antibiotic treatment and gut microbiota transplantation experiments showed that the low-dose CHI could induce MetS in mice in a gut microbiota-dependent manner. Based on the results of targeted metabolomics and gene expression analysis, the low-dose CHI could disturb the serum metabolism of bile acids (BAs) in mice, causing the inhibition of the signal response of BAs receptor farnesol X receptor (FXR) and leading to glycolipid metabolism disorders in liver tissue and epididymal white adipose tissue (epiWAT) of mice. The administration of FXR agonist GW4064 and CDCA could significantly improve the low-dose CHI-induced MetS in mice.Conclusions: In conclusion, the low-dose CHI was found to induce MetS in mice by regulating the gut microbiota and BAs metabolism via the FXR signaling pathway. This study provides evidence linking the gut microbiota and pesticides exposure with the progression of MetS, demonstrating the key role of gut microbiota in the toxic effects of pesticides.

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“…In the past few decades, a large number of pesticides have been widely used for plant protection. Pesticides may enter non-target organisms through multiple ways and bring potential health risks ( Meng et al, 2020 ). Generally, the dysbiosis of gut microbiota often occurs simultaneously with the metabolic disorder of host.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Metabolomics of Human Microbiome Studies: Recent Advances in Methods and Applications

Parolin

Zhu²,

Zhu

2021

Front. Mol. Biosci.

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Gut Microbiota: A Key Factor in the Host Health Effects Induced by Pesticide Exposure?

Cited by 48 publications

References 161 publications

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

Gut Microbiota: A Key Regulator in the Effects of Environmental Hazards on Modulates Insulin Resistance

Chlorothalonil induces metabolic syndrome in mice by regulating host gut microbiota and bile acids metabolism via FXR pathways

Editorial: Metabolomics of Human Microbiome Studies: Recent Advances in Methods and Applications

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