Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation

Sumara, Grzegorz; Sumara, Olga; Kim, Jason K.; Karsenty, G.

doi:10.1016/j.cmet.2012.09.014

Cited by 186 publications

(241 citation statements)

References 48 publications

(70 reference statements)

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“…Furthermore, serotonin has been shown to regulate glucose-stimulated insulin secretion by the b cells of the pancreas during pregnancy, and it is critical for glucosestimulated insulin secretion in an insulin-resistant state (Ohara-Imaizumi et al 2013, Kim et al 2015. Additionally, mice that were injected with increasing doses of serotonin were shown to have increased circulating leptin (Yamada et al 1989) and free fatty acid concentrations (Sumara et al 2012), which thus links serotonin with the regulation of fatty acid and energy metabolism. At present, little is known about the involvement of serotonin in glucose and energy homeostasis during lactation.…”

Section: Discussionmentioning

confidence: 98%

“…Studies have shown that serotonin is involved in liver glucose uptake mechanisms (Moore et al 2005) and glycogen metabolism (Papadimas et al 2012). Additionally, serotonin has been shown to be increased in mice that are subjected to fasting conditions, which results in the stimulation of lipolysis and liver gluconeogenesis via the serotonin receptor 2b subtype in adipocytes and hepatocytes (Sumara et al 2012). Furthermore, mice that were injected with increasing doses of serotonin responded by proportionally increasing free fatty acids (Sumara et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Laporta

Moore

Weaver

et al. 2015

Journal of Endocrinology

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A 4!4 Latin square design in which varied doses (0, 0.5, 1.0, and 1.5 mg/kg) of 5-hydroxy-L-tryptophan (5-HTP, a serotonin precursor) were intravenously infused into late-lactation, non-pregnant Holstein dairy cows was used to determine the effects of serotonin on calcium and energy metabolism. Infusion periods lasted 4 days, with a 5-day washout between periods. Cows were infused at a constant rate for 1 h each day. Blood was collected pre-and 5, 10, 30, 60, 90, and 120 min post-infusion, urine was collected pre-and post-infusion, and milk was collected daily. All of the 5-HTP doses increased systemic serotonin as compared to the 0 mg/kg dose, and the 1.0 and 1.5 mg/kg doses increased circulating glucose and non-esterified fatty acids (NEFA) and decreased beta-hydroxybutyrate (bHBA) concentrations. Treatment of cows with either 1.0 or 1.5 mg/kg 5-HTP doses decreased urine calcium elimination, and the 1.5 mg/kg dose increased milk calcium concentrations. No differences were detected in the heart rates, respiration rates, or body temperatures of the cows; however, manure scores and defecation frequency were affected. Indeed, cows that received 5-HTP defecated more, and the consistency of their manure was softer. Treatment of late-lactation dairy cows with 5-HTP improved energy metabolism, decreased loss of calcium into urine, and increased calcium secretion into milk. Further research should target the effects of increasing serotonin during the transition period to determine any benefits for post-parturient calcium and glucose metabolism.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows

Laporta

Moore

Weaver

et al. 2015

Journal of Endocrinology

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“…liver through Htr2b [8]. Plasma glycerol, produced by adipose tissue and used for gluconeogenesis, is not increased in gut-specific Tph1 knockout mice during food deprivation, though that is increased in fasted wild-type mice.…”

Section: Sumara Et Al Revealed That Gut-derived Serotonin (Gds) Incrmentioning

confidence: 97%

“…There are several peripheral tissue serotonin receptors (Htr's), and TPH1 has been shown to be expressed in peripheral tissues, which are related to energy metabolism of not only the gut but also pancreatic β cells and adipose tissue [7,8]. The roles of serotonin in energy metabolism in these tissues have been further exposed after these discoveries.…”

Section: Introductionmentioning

confidence: 99%

Energy Homeostasis by the Peripheral Serotonergic System

Watanabe

Rose²,

Kanayama

et al. 2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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Energy homeostasis is maintained by balancing energy intake and energy expenditure. In addition to the central nervous system, several hormones play a key role in energy homeostasis in the whole body. In particular, serotonin is regarded as one of the key regulators of energy homeostasis. Serotonin is unique in that it is able to act in both the brain as a neurotransmitter and the peripheral tissue as a gastrointestinal hormone. In the brain, serotonin is thought of as a pharmacological target for anti-obesity treatments because it greatly inhibits meal size and body weight gain. In contrast, serotonin in the periphery has not been targeted as a strategy for anti-obesity treatment, even though almost all of the serotonin produced in the body is produced in the peripheral tissue. Recently, the peripheral serotonergic signal has been shown to regulate glucose and lipid metabolism through autocrine and paracrine signals in energy homeostasis-related tissues, including the pancreatic β cell, liver, white adipose tissue, brown adipose tissue, and skeletal muscle. Thus, it is possible that the serotonergic system in the peripheral tissue is a new therapeutic target for metabolic disease, including obesity and diabetes. Here, we summarize the role of peripheral serotonin in the regulation of energy homeostasis.

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“…Слід відзначити, що із семи родин серотонінових рецепторів у різних клітинних популяціях печінки найбільш інтенсивно експресуються 5-НТ 2 -рецепто-ри, які опосередковують вплив аутокоїда на метаболічні та регенеративні процеси в тканині цього органа [6][7][8][9]. Нині більшість досліджень гепатотропних ефектів серото-ніну спрямовані на з'ясування його дії на регенерацію і канцерогенез у печінковій тканині [10].…”

Section: вступunclassified