Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Yang, Jungwook; Lee, Y. S.; Kim, Y.; Lee, S. H.; Ryu, Sangwon; Fukuda, Shinji; Hase, Koji; Yang, Changyuan; Lim, Hyun Sul; Kim, M. S.; Kim, Hee Man; Ahn, Sung‐Hoon; Kwon, Bo Eun; Ko, Hyun‐Jeong; Kweon, Mi‐Na

doi:10.1038/mi.2016.42

Cited by 338 publications

(242 citation statements)

References 51 publications

(58 reference statements)

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“…The gut microbiota also regulates the G-protein-coupled bile acid receptor 1 (known as TGR5) (44). Our group has detected increased levels of bile acids in fecal tissue as well as TGR5 in adipose tissue from B. acidifaciens -fed mice (45). Additional studies have suggested that bile acid-TGR5-cAMP signaling pathways enhance energy expenditure in adipose tissue (46, 47).…”

Section: Microbial Regulation Of Metabolitesmentioning

confidence: 87%

The gut microbiota: a key regulator of metabolic diseases

Yang¹,

Kweon²

2016

BMB Reports

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The prevalence of obesity and type 2 diabetes, two closely linked metabolic disorders, is increasing worldwide. Over the past decade, the connection between these disorders and the microbiota of the gut has become a major focus of biomedical research, with recent studies demonstrating the fundamental role of intestinal microbiota in the regulation and pathogenesis of metabolic disorders. Because of the complexity of the microbiota community, however, the underlying molecular mechanisms by which the gut microbiota is associated with metabolic disorders remain poorly understood. In this review, we summarize recent studies that investigate the role of the microbiota in both human subjects and animal models of disease and discuss relevant therapeutic targets for future research. [BMB Reports 2016; 49(10): 536-541]

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Section: Microbial Regulation Of Metabolitesmentioning

confidence: 87%

The gut microbiota: a key regulator of metabolic diseases

Yang¹,

Kweon²

2016

BMB Reports

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“…This shift has significant effects on GH and sugar metabolism in these taxonomic groups. Species such as B. acidifaciens and B. uniformis ameliorate obesity by immunomodulation and improved host metabolism (Gauffin Cano et al, 2012; Yang et al, 2017). However, the mechanism for these effects is unknown.…”

Section: Discussionmentioning

confidence: 99%

Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism

et al. 2018

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SUMMARY Mannose is an important monosaccharide for protein glycosylation in mammals but is an inefficient cellular energy source. Using a C57BL6/J mouse model of diet-induced obesity, we show that mannose supplementation of high-fat-diet-fed mice prevents weight gain, lowers adiposity, reduces liver steatosis, increases endurance and maximal O2 consumption, and improves glucose tolerance. Mannose-supplemented mice have higher fecal energy content, suggesting reduced caloric absorption by the host. Mannose increases the Bacteroidetes to Firmicutes ratio in the gut microbiota, a signature associated with the lean phenotype. These beneficial effects of mannose are observed when supplementation is started early in life. Functional transcriptomic analysis of cecal microbiota revealed profound and coherent changes in microbial energy metabolism induced by mannose that are predicted to lead to reduced energy harvest from complex carbohydrates by gut microbiota. Our results suggest that the gut microbiota contributes to mannose-induced resistance to deleterious effects of a high-fat diet.

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“…However, the abundances of Bacteroides (most abundant sequence: Bacteroides acidifaciens) and Ruminococcus (most abundant sequence: Clostridium fusiformis) correlated negatively with the weight of epididymal adipose tissue. Most recently, Yang et al (32) reported that Bacteroides acidifaciens was significantly increased in feces of dendritic cell-specific autophagyrelated gene 7 (Atg7)-deleted mice, and that the body weight and fat mass of the mice were reduced when compared with control mice. Furthermore, mice fed with Bacteroides acidifaciens showed elevated concentrations of insulin and glucagon-like peptide-1 in the serum, thereby reducing the body weight and fat mass.…”

Section: Discussionmentioning

confidence: 99%

Agaro-Oligosaccharides Regulate Gut Microbiota and Adipose Tissue Accumulation in Mice

Higashimura

Baba

Inoüe

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Gut microbiota are deeply associated with the prevalence of obesity. Agarose is hydrolyzed easily to yield oligosaccharides, designated as agaro-oligosaccharides (AGO). This study evaluated the effects of AGO on obese phenotype and gut microbial composition in mice. Mice were administered AGO in drinking water (AGO-receiving mice). 16S rRNA gene sequencing analyses revealed their fecal microbiota profiles. Serum bile acids were ascertained using a LC-MS/MS system. Compared to the control group, AGO administration significantly reduced epididymal adipose tissue weights and serum non-esterified fatty acid concentrations, but the cecal content weights were increased. Data from the serum bile acid profile show that concentrations of primary bile acids (cholic acid and chenodeoxycholic acid), but not those of secondary bile acids (deoxycholic acid, lithocholic acid, and ursodeoxycholic acid), tended to increase in AGO-receiving mice. 16S rRNA gene sequencing analyses showed that the relative abundances of 15 taxa differed significantly in AGO-receiving mice. Of these, the relative abundances of Rikenellaceae and Lachnospiraceae were found to be positively correlated with epididymal adipose tissue weight. The relative abundances of Bacteroides and Ruminococcus were correlated negatively with epididymal adipose tissue weight. Although the definitive role of gut microbes of AGO-received mice is still unknown, our data demonstrate the possibility that AGO administration affects the gut microbial composition and inhibits obesity in mice.

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Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

Cited by 338 publications

References 51 publications

The gut microbiota: a key regulator of metabolic diseases

The gut microbiota: a key regulator of metabolic diseases

Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism

Agaro-Oligosaccharides Regulate Gut Microbiota and Adipose Tissue Accumulation in Mice

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