Gut bacterial profiles in Parkinson's disease: A systematic review

Li, Zhe; Liang, Hongfeng; Hu, Yingyu; Lin, Li Jen; Zheng, Chunye; Fan, Yuzhen; Wu, Bin; Zou, Tao; Luo, Xiaodong; Xinchun, Zhang; Zeng, Yan; Liu, Ziyan; Zhou, Zhicheng; Yue, Zhenyu; Ren, Yi; Li, Zhuo; Q, Su; Xu, Pingyi

doi:10.1111/cns.13990

Cited by 74 publications

(54 citation statements)

References 92 publications

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“…Environmental and social factors may also influence risk for stroke, with recognition of the impact of commensal microorganisms on health and disease. 59,60 Emerging gut-brain-microbiome research using murine models, humanized mouse models, and human clinical trials 61,62 has shown that microbiome-related metabolic changes can be induced by stress, 63 exercise, 64 and even changes in the circadian rhythm. These alterations in metabolite composition have been shown across different brain regions, peripheral organs, and in circulation.…”

Section: Association Of Gut Microbiota With Circulating Metabolitesmentioning

confidence: 99%

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Ament

Patki

Bhave

et al. 2023

J Cereb Blood Flow Metab

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Several metabolite markers are independently associated with incident ischemic stroke. However, prior studies have not accounted for intercorrelated metabolite networks. We used exploratory factor analysis (EFA) to determine if metabolite factors were associated with incident ischemic stroke. Metabolites (n = 162) were measured in a case-control cohort nested in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which included 1,075 ischemic stroke cases and 968 random cohort participants. Cox models were adjusted for age, gender, race, and age-race interaction (base model) and further adjusted for the Framingham stroke risk factors (fully adjusted model). EFA identified fifteen metabolite factors, each representing a well-defined metabolic pathway. Of these, factor 3, a gut microbiome metabolism factor, was associated with an increased risk of stroke in the base (hazard ratio per one-unit standard deviation, HR = 1.23; 95%CI = 1.15–1.31; P = 1.98 × 10−10) and fully adjusted models (HR = 1.13; 95%CI = 1.06–1.21; P = 4.49 × 10−4). The highest tertile had a 45% increased risk relative to the lowest (HR = 1.45; 95%CI = 1.25–1.70; P = 2.24 × 10−6). Factor 3 was also associated with the Southern diet pattern, a dietary pattern previously linked to increased stroke risk in REGARDS (β = 0.11; 95%CI = 0.03–0.18; P = 8.75 × 10−3). These findings highlight the role of diet and gut microbial metabolism in relation to incident ischemic stroke.

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Section: Association Of Gut Microbiota With Circulating Metabolitesmentioning

confidence: 99%

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Ament

Patki

Bhave

et al. 2023

J Cereb Blood Flow Metab

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“…A previous review showed results similar to the current study, expressed as the higher abundance of Verrucomicrobiaceae, Christensenellaceae and Bifidobacteriaceae in PD subjects compared with controls. 55 In addition, it was reported that the abundance of Prevotellaceae is lower in PD subjects compared with controls. While the mentioned review showed different results regarding Ruminococcaceae which have been reported to be highly abundant in PD subjects in 3 studies, 55 in the current research, 10 studies have been selected and analyzed to reflect the conclusion of a non-significant difference between PD and controls.…”

Section: Discussionmentioning

confidence: 99%

“…55 In addition, it was reported that the abundance of Prevotellaceae is lower in PD subjects compared with controls. While the mentioned review showed different results regarding Ruminococcaceae which have been reported to be highly abundant in PD subjects in 3 studies, 55 in the current research, 10 studies have been selected and analyzed to reflect the conclusion of a non-significant difference between PD and controls. Another study by Romano et al showed the results similar to the current studies regarding the abundance of Bifidobacteriaceae, Lachnospiraceae and Faecalibacterium in PD subjects compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the relations between gut microbiota and pathogens and Parkinson’s disease

Zhou¹,

Li²,

Deng³

et al. 2023

Adv Clin Exp Med

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Background. The motor symptoms in patients with Parkinson's disease (PD) are commonly preceded by gastrointestinal (GI) symptoms. The enteric nervous system (ENS) has also been reported to exhibit neuropathological characteristics of PD. Objectives.To evaluate the relationship between the incidence of parkinsonism and alteration in gut microbiota and pathogens. Materials and methods.Studies in different languages that evaluate the relationship between gut microorganisms and PD were included into this meta-analysis. The outcomes of these studies were analyzed using a random effects model; it was also used to calculate the mean difference (MD) with 95% confidence interval (95% CI) in order to quantify the impact of different rehabilitation techniques on clinical parameters. Dichotomous and continuous models were used for the analysis of extracted data. Results.A total of 28 studies were included in our analysis. The analysis of small intestinal bacterial overgrowth showed a significant correlation with Parkinson's subjects compared with controls (p < 0.001). In addition, the presence of Helicobacter pylori (HP) infection was significantly related to the Parkinson's group (p < 0.001). On the other hand, there was a significantly higher abundance level of Bifidobacteriaceae (p = 0.008), Verrucomicrobiaceae (p < 0.001) and Christensenellaceae (p = 0.003) in Parkinson's subjects. In contrast, a significantly lower abundance levels in Parkinson's subjects were found in Faecalibacterium (p = 0.03), Lachnospiraceae (p = 0.005) and Prevotellaceae (p = 0.005). No significant difference was related to Ruminococcaceae. Conclusion.Parkinson's subjects showed a higher degree of alteration of gut microbiota and pathogens compared with normal human subjects. Future multicenter randomized trials are needed.

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“…This is supported by more than 15 cohort studies which found correlations between neurological deterioration and gut dysbiosis characterised by reduced Prevotella, lower levels of faecal short-chain fatty acids (SCFAs), increased lipopolysaccharide-(LPS) producing bacteria, and increased proinflammatory Lactobacillaceae (Li et al, 2023). Murine models have built on this concept.…”

Section: Intestinal Phenotype Hypothesismentioning

confidence: 94%

Microbiota and probiotics: chances and challenges – a symposium report

Ruxton¹,

Kajita²,

Pot³

2023

Gut. Microb.

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The 10 th International Yakult Symposium was held in Milan, Italy, on 13-14 October 2022. Two keynote lectures covered the crewed journey to space and its implications for the human microbiome, and how current regulatory systems can be adapted and updated to ensure the safety of microorganisms used as probiotics or food processing ingredients. The remaining lectures were split into sections entitled 'Chances' and 'Challenges'. The 'Chances' section related to opportunities for the science of probiotics and fermented foods to contribute to diverse areas of health such as irritable bowel syndrome, major depression, Parkinson's Disease, immune dysfunction, infant colic, intensive care, respiratory infections, and promoting healthy longevity. The 'Challenges' section included selecting appropriate clinical trial participants and methodologies to minimise heterogeneity in responses, how to view probiotics in the context of One Health, and understanding how substances of bacterial origin can cross the blood-brain barrier. The symposium provided evidence from cutting-edge research that gut eubiosis is vital for human health and, like space, the microbiota deserves further exploration of its vast potential.

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Gut bacterial profiles in Parkinson's disease: A systematic review

Cited by 74 publications

References 92 publications

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Meta-analysis of the relations between gut microbiota and pathogens and Parkinson’s disease

Microbiota and probiotics: chances and challenges – a symposium report

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