Gut bacteria formation and influencing factors

Yang, Jing; Wu, Jian; Li, Yating; Zhang, Yong’e; Cho, William C.; Ju, Xingrong; Schothorst, Evert M. van; Zheng, Yadong

doi:10.1093/femsec/fiab043

Cited by 10 publications

(6 citation statements)

References 117 publications

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“…Certainly, levels of gut microbiota are susceptible to many factors, such as age, gender, diet, geographical location, exercise, drug usage, metabolism, and surgery ( Yang et al, 2021 ). Especially, ketogenic diet can control seizure attack.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbial Characteristics of Adult Patients With Epilepsy

et al. 2022

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ObjectiveTo characterize the intestinal flora of patients with epilepsy and its correlation with epilepsy.MethodsPatients with ages > 18 years were consecutively enrolled from the outpatient department, Affiliated Hospital of Guizhou Medical University from January 2018 to December 2019. A total of 71 subjects were recruited, including epilepsy patients (n = 41) as an observation group and patient family members (n = 30) as a control group. Fresh stool specimens of all the subjects were collected. The 16S ribosomal RNA sequencing was analyzed to determine changes in intestinal flora composition and its correlation with epilepsy. Subgroup analysis was then conducted. All patients with epilepsy were divided into an urban group (n = 21) and a rural group (n = 20) according to the region, and bioinformatics analyses were repeated between subgroups.ResultsLEfSe analysis showed that Fusobacterium, Megasphaera, Alloprevotella, and Sutterella had relatively increased abundance in the epilepsy group at the genus level. Correlation analysis suggested that Fusobacterium sp. (r = 0.584, P < 0.01), Fusobacterium mortiferum (r = 0.560, P < 0.01), Ruminococcus gnavus (r = 0.541, P < 0.01), and Bacteroides fragilis (r = 0.506, P < 0.01) were significantly positively correlated with the occurrence of epilepsy (r ≥ 0.5, P < 0.05). PICRUSt function prediction analysis showed that there were significant differences in 16 pathways between the groups at level 3. Comparing the rural group with the urban group, Proteobacteria increased at the phylum level and Escherichia coli, Fusobacterium varium, Prevotella stercorea, and Prevotellaceae bacterium DJF VR15 increased at the species level in the rural group.ConclusionThere were significant differences in the composition and functional pathways of gut flora between epilepsy patients and patient family members. The Fusobacterium may become a potential biomarker for the diagnosis of epilepsy.

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Section: Discussionmentioning

confidence: 99%

Gut Microbial Characteristics of Adult Patients With Epilepsy

et al. 2022

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“…Moreover, the gastrointestinal tract is one of the critical immune organs of the body, which also helps resist the invasion of exogenous pathogenic factors and maintains the homeostasis of the intestinal environment [ 40 ]. It is normal for the gut microbiota, the host, and the external environment to establish a dynamic equilibrium, and the type and quantity of the gut microbiota are relatively stable [ 41 ]. However, AFB1 exposure disrupts the gut microbiota [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms

et al. 2023

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Aflatoxin B1 (AFB1) is a common mycotoxin that widely occurs in feed and has severe hepatotoxic effects both in humans and animals. Total flavonoids of Rhizoma Drynaria (TFRD), a traditional Chinese medicinal herb, have multiple biological activities and potential hepatoprotective activity. This study investigated the protective effects and potential mechanisms of TFRD against AFB1-induced liver injury. The results revealed that supplementation with TFRD markedly lessened broiler intestinal permeability by increasing the expression of intestinal tight junction proteins, as well as correcting the changes in gut microbiota and liver damage induced by AFB1. Metabolomics analysis revealed that the alterations in plasma metabolites, especially taurolithocholic acid, were significantly improved by TFRD treatment in AFB1-exposed chickens. In addition, these metabolites were closely associated with [Ruminococcus], ACC, and GPX1, indicating that AFB1 may cause liver injury by inducing bile acid metabolism involving the microbiota–gut–liver axis. We further found that TFRD treatment markedly suppressed oxidative stress and hepatic lipid deposition, increased plasma glutathione (GSH) concentrations, and reversed hepatic ferroptosis gene expression. Collectively, these findings indicate that ferroptosis might contribute to the hepatotoxicity of AFB1-exposed chickens through the microbiota–gut–liver axis interaction mechanisms; furthermore, TFRD was confirmed as an herbal extract that could potentially antagonize mycotoxins detrimental effects.

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“…The study showed that there was a significant difference in the mean age between PA patients and primary hypertension patients. Several studies have revealed that age is a factor influencing the gut microbiota (41)(42)(43)(44). As people age, key changes in gut microbiota include compositional instability, reduced overall diversity, and an increase in proinflammatory opportunistic pathogens.…”

Section: Discussionmentioning

confidence: 99%

Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients

et al. 2021

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PurposeThis study aimed to determine the relationships among gut microbiota, primary aldosteronism (PA), and related metabolic disorders.MethodsThe study enrolled 13 PA patients, 26 sex-matched primary hypertension patients, and 26 sex-matched healthy controls. Demographic and clinical characteristics such as age, body mass index (BMI), blood aldosterone–renin ratio, blood potassium, blood glucose, blood lipid parameters, and history of diabetes mellitus (DM) were compared between the three groups. The gut microbiota of each participant was examined by 16S rRNA gene sequencing. Spearman correlation analysis was performed to demonstrate the relationship between gut microbiota and clinical characteristics.ResultsBMI and the percentage of DM in PA patients were higher than those in healthy controls (p < 0.05), but not higher than those in primary hypertension patients (p > 0.05). The gut microbiota of healthy controls and primary hypertension patients had a higher alpha diversity level than that of PA patients. PA patients had fewer short-chain fatty acid (SCFA)-producing genera (Prevotella, Blautia, Coprococcus, Anaerostipes, and Ruminococcus) and more inflammation-associated genera (Megamonas, Sutterella, and Streptococcus) than healthy controls (p < 0.05). The gut microbiota of PA patients was more inclined to encode microbial pathways involved in sugar metabolism, such as starch and sucrose metabolism and fructose and mannose metabolism. Blood potassium was negatively correlated with the relative abundance of Romboutsia (R = −0.364, q = 0.023). Diastolic blood pressure (DBP) was positively correlated with Romboutsia (R = 0.386, q = 0.015). Systolic blood pressure (SBP) was negatively correlated with Blautia (R = −0.349, q = 0.030).ConclusionsThe alteration of gut microbiota in PA patients, especially bacteria and pathways involved in inflammation, SCFAs, and sugar metabolism, may be associated with chronic metabolic disorders.

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Gut bacteria formation and influencing factors

Cited by 10 publications

References 117 publications

Gut Microbial Characteristics of Adult Patients With Epilepsy

Gut Microbial Characteristics of Adult Patients With Epilepsy

Total Flavonoids of Rhizoma Drynariae Mitigates Aflatoxin B1-Induced Liver Toxicity in Chickens via Microbiota-Gut-Liver Axis Interaction Mechanisms

Alteration of Gut Microbiota Relates to Metabolic Disorders in Primary Aldosteronism Patients

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