Gum Guar fiber associated with fructose reduces serum triacylglycerol but did not improve the glucose tolerance in rats

Abstract

IntroductionThe increased intake of dietary fructose can be associated with alterations on energy homeostasis and lipid/carbohydrate metabolism, such as insulin resistance and dislipidemia. On the other hand, the ingestion of soluble fiber gum guar could improve benefic mechanism on glucose tolerance and lipids profile.ObjectiveThe aim of the present study were to investigate the effects of the supplemental feeding partially hydrolyzed gum guar on glucose and lipid homeostasis, in rats fed with fructose solution.MethodsThe study was performed on thirty day-old male Wistar rats randomly assigned into four groups: control(C) or treated with fructose (F-20%), fiber (FB-5%), or fructose plus fiber (F-20% + FB-5% = FF) solution for 30 days on glucose tolerance (OGTT), triacylglycerol concentration in the liver by chloroform/methanol method, glucose, triacylglycerol and total cholesterol serum concentration by assayed by enzymatic colorimetric method, insulin receptor (IR) concentration in the liver by Western Blotting.ResultsThe total body weight gain was not different between groups; in regards of total caloric intake, in the F group was significantly higher and in the FB group was lower than other groups. The triacylglycerol concentration in the liver of FF group was significantly higher than F group, the triacylglycerol concentration in the serum was higher the F group compared with other groups. The OGTT reveal impaired on glucose tolerance in the F, FB, FF compared with C. The IR concentration in the liver was lower in the F, FB, FF compared with C, no significant difference was observed between groups for IR concentration in the gastrocnemius muscle. No significant difference was observed between groups for carcass fat content and serum total cholesterol.ConclusionFructose induced important alterations on glucose tolerance and lipid metabolism, despite of fiber showed reversion of part this alterations. The association fructose plus fiber to seem decrease insulin receptor concentration in the liver, with consequent impair on glucose tolerance.

The response of male and female rats to a high-fructose diet during adolescence following early administration ofHibiscus sabdariffaaqueous calyx extracts

“…58 Fructose feeding for 10 weeks in adolescent rats (150-200 g) had previously been shown to produce hyperinsulinaemia, hypertriglyceridaemia and hyperuricaemia. 59 The findings in this study are at variance with those of Motoyama, 60 who reported that fructose in feed (20%, w/v) for 2 weeks in adult rats produced insulin resistance. The age of the rats at termination (51 days) and the mode of fructose administration could have been factors responsible for the variance.…”

Short sleep duration and obesity: mechanisms and future perspectives

“…Spiegel et al showed that the appetite for energy‐rich foods with high carbohydrate content, including sweets, salty snacks and starchy foods, increased from 33% to 45% after sleep restriction, although the appetite for fruits, vegetables and high‐protein foods was less affected. This preference for such foods is concerning because in addition to presenting a hormone pattern that predisposes to increased energy intake, individuals with sleep loss tend to meet this need with foods of low nutritional quality (Figure ) …”

“…This preference for such foods is concerning because in addition to presenting a hormone pattern that predisposes to increased energy intake, 4 individuals with sleep loss tend to meet this need with foods of low nutritional quality (Figure 2). [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] In a protocol of 14 consecutive days of sleep restriction (5Á5 h of sleep per night) with ad libitum food intake, Nedeltcheva et al 57 indicated that sleep restriction led to an increase in calorie consumption that was attributed to snacking, particularly during the night when the individual would normally be sleeping. This greater opportunity to eat during the evening, which is a time of the day when people become less satisfied by a given amount of food intake and may be more vulnerable to overeating, could promote a higher susceptibility to weight gain.…”

“…Several studies have showed that hyperglycemic and hyperlipidemic conditions contribute to the development of insulin resistance in obese individuals . Some studies with animals have demonstrated that consumption of high fat and/or high carbohydrate diet leads to insulin resistance in several tissues because of inflammatory and disrupted insulin pathways …”

“…[44][45][46] Some studies with animals have demonstrated that consumption of high fat and/or high carbohydrate diet leads to insulin resistance in several tissues because of inflammatory and disrupted insulin pathways. [47][48][49][50]…”