Guinea pig soleus and extensor digitorum longus: A study on single-skinned fibers

Takagi, Akio; Endo, Makoto

doi:10.1016/0014-4886(77)90161-3

Cited by 43 publications

(27 citation statements)

References 13 publications

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“…Results obtained in many species, including rabbit (404), rat (762), guinea pig (779), and humans (219, 669), consistently indicate that the threshold for activation is lower in slow than in fast muscle fibers, whereas the Hill coefficient n is higher in fast than in slow fibers (FIG. 8A).…”

Section: Response Of Myofibrils To Calciummentioning

confidence: 91%

Fiber Types in Mammalian Skeletal Muscles

Schiaffino

Reggiani

2011

Physiological Reviews

2,243

2,465

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Mammalian skeletal muscle comprises different fiber types, whose identity is first established during embryonic development by intrinsic myogenic control mechanisms and is later modulated by neural and hormonal factors. The relative proportion of the different fiber types varies strikingly between species, and in humans shows significant variability between individuals. Myosin heavy chain isoforms, whose complete inventory and expression pattern are now available, provide a useful marker for fiber types, both for the four major forms present in trunk and limb muscles and the minor forms present in head and neck muscles. However, muscle fiber diversity involves all functional muscle cell compartments, including membrane excitation, excitation-contraction coupling, contractile machinery, cytoskeleton scaffold, and energy supply systems. Variations within each compartment are limited by the need of matching fiber type properties between different compartments. Nerve activity is a major control mechanism of the fiber type profile, and multiple signaling pathways are implicated in activity-dependent changes of muscle fibers. The characterization of these pathways is raising increasing interest in clinical medicine, given the potentially beneficial effects of muscle fiber type switching in the prevention and treatment of metabolic diseases.

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Section: Response Of Myofibrils To Calciummentioning

confidence: 91%

Fiber Types in Mammalian Skeletal Muscles

Schiaffino

Reggiani

2011

Physiological Reviews

2,243

2,465

View full text Add to dashboard Cite

show abstract

“…It is possible that skeletal muscle fibres from other mammals exhibit similar large variations in Ca2+ sensitivity at room temperature. If so, such a variability could account for previously reported apparently inconsistent differences between Ca2+ sensitivity in slow-and fast-twitch muscle fibres (Kerrick et al 1976;Takagi & Endo, 1977).…”

Section: Ca2+ Activation In Mammalian Skeletal Musclesmentioning

confidence: 88%

Calcium‐activated force responses in fast‐ and slow‐twitch skinned muscle fibres of the rat at different temperatures.

Stephenson¹,

Williams²

1981

The Journal of Physiology

373

392

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“…The difference between Ca2' and Sr2+ functional activation characteristics of fast and slow skeletal muscle fibres can be used to determine the functional fibre type. Indeed, it is generally assumed that fast skeletal muscle fibres are less sensitive to Sr2+ than slow fibres (Takagi & Endo, 1977). The difference (pCa,, -pSr,,) or A criterion, was used to reflect the relative affinity of a fibre to Ca2+ or Sr2+.…”

Section: Determination Of Tension-pca and Tension-psr Relationshipsmentioning

confidence: 99%

Evolution of contractile and elastic properties of rat soleus muscle fibres under unloading conditions

Toursel¹,

Stevens²,

Mounier³

1999

Experimental Physiology

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S U M M A R YRats were submitted to 14 days of hindlimb suspension in order to examine the contractile and elastic properties of the soleus muscles under disuse conditions. The calcium/strontium activation properties, the maximal shortening velocity ( V J , as well as the time behaviour of force transients following quick releases and the T, curves characterizing the active part of the s8eries elastic elements, were determined on single chemically skinned fibres. After the functional measurements, the fibres were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis in order to analyse both the myosin heavy (MHC) and light (MLC) chain isoforms. According to the MHC and MLC composition, two groups of fibres were defined after hindlimb suspension: a group of slow fibres expressing the slow set of both MHC and MLC isoforms, and a group of fast fibres coexpressing the slow and fast MHC and MLC isoforms with a predominant expression of the fast ones. For the first group, the contractile as well as the elastic properties were found to be close to those of control slow soleus fibres. For the second group, both contractile and elastic properties were modified insofar as they became close to those found in a fast muscle such as the extensor digitorum longus. We suggested that between the two populations found in the soleus muscle after hindlimb suspension the modifications in the contractile properties, as well as the alterations in the elastic characteristics, were concomitant to the changes in both MHC and MLC compositions.

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Guinea pig soleus and extensor digitorum longus: A study on single-skinned fibers

Cited by 43 publications

References 13 publications

Fiber Types in Mammalian Skeletal Muscles

Fiber Types in Mammalian Skeletal Muscles

Calcium‐activated force responses in fast‐ and slow‐twitch skinned muscle fibres of the rat at different temperatures.

Evolution of contractile and elastic properties of rat soleus muscle fibres under unloading conditions

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