Guillain-Barré Syndrome Outbreak Associated With Zika Virus Infection in French Polynesia

Cao-Lormeau, Van-Mai; Blake, Alexandre; Mons, Sandrine; Lastère, Stéphane; Roche, Claudine; Vanhomwegen, Jessica; Dub, Timothée; Baudouin, Laure; Teissier, Anita; Larre, Philippe; Vial, Anne-Laure; Decam, C.; Choumet, Valérie; Halstead, Susan K.; Willison, Hugh J.; Musset, Lucile; Manuguerra, Jean-Claude; Desprès, Philippe; Fournier, Emmanuel; Mallet, Henri‐Pierre; Musso, Didier; Fontanet, Arnaud; Neil, Jean; Ghawche, F

doi:10.1097/01.ogx.0000489564.35748.52

Cited by 75 publications

(116 citation statements)

References 0 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Inoculating ZIKV into mice triggered motor weakness and paralysis of the limbs, with viral replication detected in the brain tissue, suggesting neurotropism of the virus. The short time between the clinical presentation of ZIKV infection and the appearance GBS, as reported in French Polynesia (44) , may indicate a direct neuropathic effect of the virus, in addition to an immune-mediated effect that damages the peripheral nerves and spinal roots weeks after clinical presentation of the acute viral infection. These and other questions are to be clarified from future studies on the immunopathogenesis of ZIKV.…”

Section: Neurological Involvementmentioning

confidence: 99%

“…The pattern of acute motor axonal neuropathy was predominant among the cases (74%). The average time from infection to the development of neurological symptoms was 6 days (44) . A recent publication questioned the interpretation of the serologic tests performed, stating that the laboratory results were inconclusive due to potential cross reaction of dengue (45) .…”

Section: Neurological Involvementmentioning

confidence: 99%

See 1 more Smart Citation

One year after the Zika virus outbreak in Brazil: from hypotheses to evidence

Brito

Cordeiro

2016

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

In the second quarter of 2015, the association between Zika virus infection and neurological symptoms was confirmed in adults. Moreover, in October 2015 a novel suspicion was raised based on clinical and epidemiological observations: that an association between Zika virus infection and neonatal microcephaly may exist. A year after the first reports on Zika virus in Brazil, many hypotheses and much evidence on the patterns of involvement of the disease and its complications have been produced, both in this country and others; other hypotheses still need to be clarified. This review is a synthesis of a new chapter in the history of medicine; it outlines the main results produced.

show abstract

Section: Neurological Involvementmentioning

confidence: 99%

Section: Neurological Involvementmentioning

confidence: 99%

One year after the Zika virus outbreak in Brazil: from hypotheses to evidence

Brito

Cordeiro

2016

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…* Most persons infected with Zika virus have a mild illness or are asymptomatic. However, increasing evidence supports a link between Zika virus infection during pregnancy and adverse pregnancy and birth outcomes (1), and a possible association between recent Zika virus infection and GuillainBarré syndrome has been reported (2). Although Zika virus is primarily transmitted through the bite of Aedes species of mosquitoes, sexual transmission also has been documented (3).…”

Section: On March 22 2016 This Report Was Posted As An Mmwr Early Rmentioning

confidence: 99%

Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions — United States, 2016

Olson¹,

Iwamoto²,

Perkins³

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

View full text Add to dashboard Cite

“…Guillain-Barré Syndrome (topic #8) is a sickness caused by damage of nerve cells. The tweet "human neural stem cells infected by #zika subsequently trigger an innate immune response that leads to cell death" includes information on how Zika can lead to damage of neural stem cells and causes a disease like Guillain-Barré syndrome [44]. The reader can see how topics #1, #2, #5, and #8 all include information on neural issues following Zika infection, but all focus on different issues and are therefore, three separate topics.…”

Section: Neural Defectsmentioning

confidence: 99%

Identifying Key Topics Bearing Negative Sentiment on Twitter: Insights Concerning the 2015-2016 Zika Epidemic (Preprint)

Mamidi¹,

Miller²,

Banerjee³

et al. 2018

Preprint

View full text Add to dashboard Cite

Background In order to understand public sentiment regarding the Zika virus, social media can be leveraged to understand how positive, negative, and neutral sentiments are expressed in society. Specifically, understanding the characteristics of negative sentiment could help inform federal disease control agencies' efforts to disseminate relevant information to the public about Zika related issues. Objective The purpose of this study was to analyze public sentiment concerning Zika using posts on Twitter and determine the qualitative characteristics of positive, negative and neutral sentiments expressed. Methods Machine learning techniques and algorithms were used to analyze the sentiment of tweets concerning Zika. A supervised machine learning classifier was built to classify tweets into three sentiment categories: positive, neutral, and negative. Tweets in each category were then examined using a topic modeling approach in order to determine the main topics for each category, with focus on the negative category. Results A total of 5,303 tweets were manually annotated and used to train multiple classifiers. These performed moderately well (F1 score = 0.69, 0.68) with text-based feature extraction. All 48,734 tweets were then categorized into the sentiment categories. Ten topics for each sentiment category were identified using topic modeling with a focus on the negative sentiment category. Conclusions Our study demonstrates how sentiment expressed within discussions of epidemics on Twitter can be discovered. This allows public health officials to understand public sentiment regarding an epidemic and enables them to address specific elements of negative sentiment in real-time. Our negative sentiment classifier was able to identify tweets concerning Zika with three broad themes: neural defects, Zika abnormalities, and reports and findings. These broad themes were based on domain expertise and from topics discussed in journals such as MMWR and Vaccine. Since the majority of topics in the negative sentiment category concerned symptoms, officials should focus on spreading information about prevention and treatment research.

show abstract

Guillain-Barré Syndrome Outbreak Associated With Zika Virus Infection in French Polynesia

Cited by 75 publications

References 0 publications

One year after the Zika virus outbreak in Brazil: from hypotheses to evidence

One year after the Zika virus outbreak in Brazil: from hypotheses to evidence

Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions — United States, 2016

Identifying Key Topics Bearing Negative Sentiment on Twitter: Insights Concerning the 2015-2016 Zika Epidemic (Preprint)

Contact Info

Product

Resources

About