Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus

Braathen, Lasse R.; Szeimies, Rolf‐Markus; Basset-Séguin, Nicole; Bissonnette, Robert; Foley, Peter; Pariser, David M.; Roelandts, Rik; Wennberg, Ann‐Marie; Morton, C.A.

doi:10.1016/j.jaad.2006.06.006

Cited by 593 publications

(566 citation statements)

References 83 publications

(88 reference statements)

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“…Topical Photodynamic therapy (PDT) has been widely used in dermatology for the treatment of superficial non-melanoma skin cancer (SNMSC) and dysplasia with overall 70-90% clearance rates 1,2,3 . There are British and International Guidelines for the use of PDT in these conditions 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…There are British and International Guidelines for the use of PDT in these conditions 1,2 . The most common diagnoses treated by PDT are superficial basal cell carcinoma (sBCC), Bowen's disease (BD), and actinic keratosis (AK) 1,2,3 . AK is a pre-malignant skin condition arising as a consequence of chronic sun exposure and if left untreated can progress to squamous cell carcinoma (SCC) 4 .…”

Section: Introductionmentioning

confidence: 99%

“…AK and sBCC respond better to PDT than nodular BCC, arguably due to the fact that the prodrug used is taken up and metabolised more efficiently in the superficial layers of skin than in deeper layers 6 . PDT results in excellent cosmetic outcomes, and healing 1,2 . However, results could be improved and based on our Scottish experience, 26% of the lesions require more than one cycle of treatment 3 .…”

Section: Introductionmentioning

confidence: 99%

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Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Kulyk

Ibbotson

Moseley

et al. 2015

Photodiagnosis and Photodynamic Therapy

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3 HighlightsWe developed a handheld device and a time course method for fluorescence imagingThe device can be used to study PpIX formation in healthy and diseased skin PpIX fluorescence grows throughout the 3 hours prior to treatmentThe fluorescence intensity varies between diagnoses and individuals The fluorescence depends on the body site, possibly due to differences in temperature 4 Abstract Background

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Kulyk

Ibbotson

Moseley

et al. 2015

Photodiagnosis and Photodynamic Therapy

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“…These therapeutic options involve different degrees of efficacy and may be followed by different side effects such as secondary infection, slow healing, pain or discomfort, scarring and changes in pigmentation. [12][13][14][15] In 1978, Dougherty et al 16 were the first to use PDT clinically. From that time onwards, it has been used to treat different types of tumor.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][18][19][20][21] PDT has therefore been classified as a treatment option with good therapeutic selectivity, significant cure rates, good tolerability and favorable cosmetic results. Furthermore, it allows larger areas of the body to be treated, thereby enabling multiple actinic keratoses and areas affected by cancer to be treated simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

Ritter

Kuhl

Lenhardt

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Photodynamic therapy is a form of treatment in which a photosensitizing substance is applied to tissue and activated by a light source at a specific wavelength, thus selectively destroying cells. New light sources are being evaluated for use in the treatment of actinic keratoses. OBJECTIVES: To evaluate the efficacy of photodynamic therapy with delta-aminolevulinic acid using a light emitting diode device as a light source in the treatment of actinic keratoses of the face and upper limbs. METHODS: Eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm. RESULTS: A total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. Lesions situated on the back of the hands were clinically cured in 49.2% of cases compared to 81.4% in the cases of lesions in other areas. There was no record of any severe adverse effects and patient satisfaction with the results was high. CONCLUSION: Photodynamic therapy with a diode light emitting source proved effective and well-tolerated for the treatment of actinic keratoses, with results similar to those reported in the literature with other light sources. Keywords: Keratosis; Photobiology; Photochemotherapy Resumo: FUNDAMENTOS: A terapêutica fotodinâmica é técnica de tratamento em que se aplica uma substân-cia fotossensibilizante nos tecidos ativada por uma fonte de luz de comprimento de onda específico, gerando destruição celular seletiva. Estudam-se novas fontes de luz que possam ser usadas no tratamento de ceratoses actínicas. OBJETIVOS: Avaliar a efetividade da terapêutica fotodinâmica com ácido delta-aminolevulínico utilizando como fonte de luz um aparelho emissor de luz de diodos no tratamento de ceratoses actínicas de face e membros superiores. MÉTODOS: Dezoito pacientes com ceratoses actínicas na face ou membros superiores realizaram uma aplicação de creme de ácido delta-aminolevulínico a 20% e foram submetidos à exposição de luz de diodos, comprimento de onda de 630 nm. RESULTADOS: Foram tratadas 328 ceratoses actínicas, obtendo-se cura clínica completa em 210 (64,0%) após 24 semanas. Lesões do dorso das mãos apresentaram cura clínica completa em 49,2%; nas demais áreas esse valor foi de 81,4%. Não houve registro de efeitos adversos graves, e obteve-se bom grau de satisfação dos pacientes com os resultados. CONCLUSÃO: A terapêutica fotodinâmica com fonte de emissão de luz de diodos mostrou-se eficaz e bem tolerada para tratamento de ceratoses actínicas, com resultados semelhantes aos encontrados na literatura utilizando outras fontes luminosas.

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Pathologic Changes After Photodynamic Therapy for Basal Cell Carcinoma and Bowen Disease

Fantini

Greco²,

Cesinaro³

et al. 2008

Arch Dermatol

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To investigate the in vivo reactions and the mechanisms of cell death after photodynamic therapy (PDT) for cutaneous carcinomas. Photodynamic therapy is a new treatment modality for nonmelanoma skin cancers. Its effects on target tissue have been well investigated in vitro, where apoptosis appears to be the main effector mechanism, but its effects remain undefined in vivo. Design: Skin biopsy specimens were obtained sequentially after PDT for basal cell carcinoma and in situ squamous cell carcinoma (Bowen disease). Evidence from routine histologic evaluation was compared with a panel of apoptosis-related (TUNEL [terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling], caspase-3, and Bcl-2) and inflammatory (CD4, CD8, CD20, CD68, and CD56) markers. We used electron microscopy to evaluate cell damage at the ultrastructural level. Main Outcome Measures: Evidence of the mechanisms of tumor cell damage after PDT, detection of histologic and/or immunohistochemical signs of apoptosis, and time course of the tumor destruction and inflammatory reaction. Results: Early epidermal damage and an acute dermal inflammatory response were detected 15 minutes after PDT. In basal cell carcinoma, nodule damage progressed from scant apoptotic cells seen at the dermalepithelial junction to massive destruction seen after 1 and 2 days. The periphery of the basaloid nodules consistently showed earlier and predominant damage, as demonstrated by the perfect coincidence of histologic and immunohistochemical evidence with apoptotic markers (TUNEL and caspase-3 staining). Fibrosis and lentigolike changes were seen in late biopsy specimens. Conclusions: This study defines the time course and characteristics of the skin tumor response to PDT. Taken together, our observations suggest that direct damage to cancer cells is the main effector mechanism leading to PDT response. The involvement of apoptosis is demonstrated by the simultaneous appearance of histologic, immunohistochemical, and ultrastructural markers that occur in the early phases of the cutaneous reaction to PDT. These observations could help to develop future refinements of the PDT technique.

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Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus

Cited by 593 publications

References 83 publications

Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Development of a handheld fluorescence imaging device to investigate the characteristics of protoporphyrin IX fluorescence in healthy and diseased skin

Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

Pathologic Changes After Photodynamic Therapy for Basal Cell Carcinoma and Bowen Disease

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