Abstract:Acquired hemophilia A is an autoimmune disease caused by antibodies against coagulation factor VIII (FVIII). These antibodies, called circulating FVIII anticoagulant or FVIII inhibitor, reduce plasma FVIII activity, which results in excessive bleeding. Acquired hemophilia A is classified as severe hemorrhagic disorder. Typical for this disease are extensive subcutaneous spontaneous blood extravasations, intramuscular and retroperitoneal hematomas, and post--traumatic bleeds, including post-surgery bleeding. In… Show more
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