Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group

Reproducibility of histological subtyping of malignant pleural mesothelioma

“…The 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group guidelines recognized difficulties with pattern recognition in small biopsies, and recommended using three main histological types (epithelioid, sarcomatoid, biphasic) with pattern descriptions in medical records, if possible [13]. Histological subtyping/patterns in many carcinomas correlate with patients' clinicopathological characteristics [17][18][19][20][21][22].…”

“…and S.S.) and classified as epithelioid, sarcomatoid or biphasic type, according to the 2004 WHO classification criteria for pleural tumors [9], and used a median of 3 slides per case (range: 1-16). Epithelioid MPM were further subtyped according to their predominant patterns as acinar, adenomatoid (microglandular), micropapillary, solid, tubulopapillary, and trabecular as defined previously [11,13,14] (Fig. 1 and 2).…”

“…The importance of histological subtyping lies in their significant bearing on survival, with epithelioid having the best prognosis [11], whereas the pleomorphic subtype and sarcomatoid MPMs both reportedly have similarly poor outcomes [12]. The 2012 Update of the Consensus Statement from the International Mesothelioma Interest Group recommended that MPM diagnoses include subtype if possible, with histological pattern in the description [13]. So far, only Kadota et al have comprehensively subtyped epithelioid mesothelioma and correlated its clinicopathological characteristics and prognosis, mainly using extrapleural pneumectomy and pleurectomy decortication samples; their study suggested reclassifying pleomorphic epithelioid mesothelioma as a biphasic or sarcomatoid type based on its very poor survival [11], which accords with an earlier study by Ordonez who analyzed 10 pleomorphic mesotheliomas [12].…”

Role of Imaging in Peritoneal Surface Malignancies

“…The epithelioid variety has a much better prognosis as compared to the other varieties and is treated aggressively. The cytological and histologic features of MPM have been described in recent articles [43,44]. The tumor arises from mesothelial cells lining the peritoneal cavity.…”

Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

“…Both cell lines expressed keratin 5/6, podoplanin, WT1, calretinin and mesothelin which are often used as mesothelioma markers for pathological diagnosis (11). On the other hand, neither cell line expressed TTF-1 or CEA; they are not generally expressed in MPM, and are often used as markers of lung adenocarcinoma (11). The expressions of those marker genes of mesothelioma and origin of HMM-1 and HMM-3 cell lines suggested that the two cell lines were mesothelioma cells.…”