Guideline for diagnostic, prevention and treatment of postmenopausal osteoporosis

Grygorieva, N.V.; Kovalenko, V.M.; Коrzh, М.О.; Tatarchuk, T.F.; Dedukh, N.V.; Strafun, S.S.; Dubossarska, Z.M.; Protsenko, G.O.; Kalashnikov, A.V.; Musiіenko, А.S.; Regeda, S.I.; Efimenko, O.O.; Chaykivska, E.F.

doi:10.22141/pjs.13.3.2023.378

Cited by 5 publications

(3 citation statements)

References 189 publications

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“…та локаль них (паракринних і аутокринних) факторів, зокрема, синтезом цитокінів, хемокінів, факторів росту тощо [3]. Нині до цих чинників відносять і вітамін D, який реалізує свою дію в організмі людини у вигляді активного метаболіту -1α,25(OH) 2 D 3 (кальцитріол) [4][5][6]. До «класичних», скелетних ефектів вітаміну D відносять підтримку кальційфосфатного гомеостазу через вплив на абсорбцію та екскрецію вищезазначених мінеральних елементів у шлунково-кишко вому тракті, нирках та регуляцію функціонування прищитоподібних залоз.…”

Section: вступunclassified

“…Нині доведено, що вітамін D через VDR безпосередньо впливає на епігеном і транскриптом клітин [13]. Проведені остан німи десятиліттями дослідження дають змогу детальніше зрозуміти роль вітаміну D у життєдіяльності клітин кісткової тканини [3,4,14], узагальнення цих відомостей обме жені, що і стало підставою для нашого аналізу.…”

Section: вступunclassified

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The Role of Vitamin D in the Functioning of Bone Cells

Dedukh,

Grygorieva

2023

Fiziol Zh

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The review summarizes current literature data on the importance of vitamin D in bone cell function. An analytical search was conducted in the PubMed, MEDLINE, Embase, Scopus, and Web of Science databases from January 1, 2018, to June 01, 2023. The vitamin D metabolite 1α,25(OH)2D3 plays an important role in the regulation of mineral homeostasis and bone metabolism. It has catabolic and anabolic actions on osteoblasts, osteocytes and mature osteoclasts. In this review, we describe the direct and indirect effects of 1α,25(OH)2D3 on the function of mesenchymal stromal cells (MSCs), osteoblasts, osteocytes, and osteoclasts. Among the targets of vitamin D action in bone cells are vitamin D receptor (VDR) and cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1). In osteoblasts and MSCs with CYP27B1 knockout, cell proliferation and differentiation are impaired, and in osteoclasts, the resorption activity and lifespan of these cells are increased. The role of VDR in bone cells was demonstrated in normal and VDR-knockout animal models. The relationship between 1α,25(OH)2D3 – VDR signal transduction by bone cells and calcium balance was analyzed. In osteocytes, as well as in osteoblasts, 1α,25(OH)2D3 regulates the expression of RANKL (receptor activator of nuclear factor kappa-B ligand)), and additionally in osteocytes regulates the expression of FGF-23. The interaction of many other factors in bone cells has been shown to control the biological activity of 1α,25(OH)2D3. Thus, the effect of vitamin D on bone cells is in the phase of active research and requires an in-depth study of the features of its autocrine and paracrine effects. Identification of the molecular links of the mechanism of action of 1α,25(OH)2D3 on bone metabolism will provide a fundamental basis for approaches to the treatment of vitamin D deficiency diseases.

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The Role of Vitamin D in the Functioning of Bone Cells

Dedukh,

Grygorieva

2023

Fiziol Zh

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“…Every third woman and at least every sixth man experience an osteoporotic fracture during their lifetime. According to research conducted at the Ukrainian Osteoporosis Center, the number of women with osteoporo sis in Ukraine today may exceed 1.8 million [5]. Osteoporotic fractures result in reduced life expectancy and loss of patient abilities, with significant sociomedical consequences for both patients and the healthcare system [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the bone biological age using multiple regression and neural network analysis

Grygorieva,

Pisaruk,

Gurianov

et al. 2024

PJS

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Background. Nowadays, many studies confirm the increased risk of osteoporosis in the elderly. Strategies for optimizing diagnosis include a combined use of various methods, so calculating bone biological age (BA) can also be important for disease prediction. Recently, some new methodological approaches to BA calculation with the mathematical methods implementation were proposed. However, studies utilizing advanced approaches, particularly neural network (NN) in Ukraine, are limited. The purpose of this study was to develop a bone BA model and compare its accuracy using stepwise multiple regression (MLR) and NN analysis methods. Materials and methods. In a single-center cohort study, we retrospectively analyzed the data of 3,071 healthy women aged 40–90 years. The analysis of the study indices included the anthropometric parameters, dual-energy X-ray absorptiometry indices (DXA), and the parameters of the 10-year probability of major osteoporotic fractures (FRAX). For the development of bone BA models, MLR methods were used and the construction of the NN model was performed using a multilayer perceptron model. Results. As a result of the calculation, we received the MLR formula for bone BA determining bone mineral density (BMD) of lumbar spine and radius, minimal femoral and hip BMD as well as Trabecular Bone Score, and FRAX. The MLR equation allowed to calculation of the bone BA with an error of less than 4.9 years for study and control groups and demonstrated the high connection between calculated and chronological (ChrA) ages (R = 0.77; p < 0.00001). The use of NN analysis showed the best results using 6 input variables and 1 internal layer of 7 neurons. The assessment of the connection between BA and ChrA demonstrated a high coefficient of correlation (R = 0.88; p < 0.000001) with an average error of age calculation of less than 3.7 years for the study and control groups. Conclusions. A comparison of the accuracy of both models in bone BA estimation revealed a significant advantage of the deep learning NN, however, the use trained NN model requires specialized software, whereas the MLR formula can be used without additional costs.

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The influence of glucocorticoids on the bone tissue in patients with chronic obstructive pulmonary disease

Masik,

Niushko

2024

PJS

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Background. According to the GOLD guidelines, glucocorticoids (GCs) are recommended for exacerbations of chronic obstructive pulmonary disease (COPD). Bone mineral density (BMD) can be reduced in case of the use of therapeutic doses of GCs. The aim of the study was to determine the influence of GCs on BMD and the frequency of osteoporosis in patients with COPD depending on the prescribed therapy. Materials and methods. We examined 202 patients with COPD (group E) in the acute phase. Group I consisted of 129 patients taking basic dual treatment, group II — 73 patients taking triple therapy with inhaled GCs. During exacerbations, systemic GCs were prescribed at the cumulative dose of 352.94 ± 30.51 mg/year. The bone state was examined using an ultrasound densitometer SONOST-2000. A Speed of Sound (SOS), Broadband Ultrasound Attenuation (BUA), Stiffness index (SI), and T- and Z-scores were determined. Results. Decreases in SI, BUA, T- and Z- scores were established in 43.51 % of the patients from the I group and 83.56 % from the II group (p < 0.05). In the II group, SI was lower by 9.54 %, BUA — by 14.35 %, SOS — by 14.57 %, T- score — by 6.9 %, Z- score — by 25.86 %; in subjects with GOLD 3: BUA — by 40.27 %, SI — by 3.25 %, T- score — by 17.9 %; in patients with GOLD 4: SI — by 19.9 %, BUA — by 77.8 %, T- score — by 5.6 % compared to the I group. Conclusions. Glucocorticoid-induced osteoporosis was diagnosed in 10.71 % of patients from the I group and 20.55 % of the II group. Its frequency depended on the stage of COPD: GOLD 3 — in 22.22 % of patients, GOLD 4 — in 50.0 % of the subjects.

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Guideline for diagnostic, prevention and treatment of postmenopausal osteoporosis

Cited by 5 publications

References 189 publications

The Role of Vitamin D in the Functioning of Bone Cells

The Role of Vitamin D in the Functioning of Bone Cells

Assessment of the bone biological age using multiple regression and neural network analysis

The influence of glucocorticoids on the bone tissue in patients with chronic obstructive pulmonary disease

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