GSTM1 and GSTP1 , but not GSTT1 genetic polymorphisms are associated with chronic myeloid leukemia risk and treatment response

Influence of glutathione S‐transferases (GSTM1, GSTT1, and GSTP1) genetic polymorphisms and smoking on susceptibility risk of chronic myeloid leukemia and treatment response

“…The findings showed that GSTM1null and GSTP1M*(AG/ GG) together [GSTM1-null/GSTP1M*(AG/GG)] and with GSTT1 present are associated with CML development and increased risk especially for GSTM1-null/ GSTP1M* genotype is superadditive. This finding is in agreement with other studies (Weich et al, 2016)). We carried out further analysis in order to determine the influence of simultaneous presence of GSTs genetic polymorphisms and smoking as an environmental risk factor that its role well has been fixed for lung cancer.…”

“…Similar results with our findings were clearly described regarding increased risk of CML for the GSTM1/null genotype by Bhat et al (), Lordelo et al () and Al‐Achkar et al (). In contrast, several studies suggested that GSTM1 may not be predisposing factor for CML risk (Taspinar et al, ; Weich et al, ). In this study, no association was found between CML risk and GSTT1 polymorphism, consistent with Weich et al () report, this finding may be due to low frequency of individuals carrying the GSTT1‐null genotype or indicating a protective effect of GSTT1/null on CML risk.…”

“…In contrast, several studies suggested that GSTM1 may not be predisposing factor for CML risk (Taspinar et al, ; Weich et al, ). In this study, no association was found between CML risk and GSTT1 polymorphism, consistent with Weich et al () report, this finding may be due to low frequency of individuals carrying the GSTT1‐null genotype or indicating a protective effect of GSTT1/null on CML risk. Contrary to our data, several studies have described increased risk of CML associated with the GSTT1/null genotype in different ethnicities (Özten et al, ; Taspinar et al, ).…”

“…Several studies determined only the role of GST polymorphisms on CML susceptibility (Al-Achkar, Azeiz, Moassass, & Wafa, 2014;He et al, 2014;Özten et al, 2012) and some studies assessed their impact on treatment response (Davies et al, 2014;Kassogue et al, 2014). A recent study has evaluated the effect of GST polymorphisms on CML susceptibility and treatment response, but the interaction between these genes and environmental exposures or risk factors such as cigarette smoke was not evaluated in CML development (Weich et al, 2016). Little is known about the relation between GST polymorphisms and smoking associated with the risk of CML development, predicting treatment response, and clinical outcome simultaneously.…”

Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk

“…[16] The three GSTs GSTM1, GSTT1, and GSTP1 are the predominant members of the GST family, and deletion of the gene encoding GSTM1 or GSTT1 or the polymorphism Ile105Val (rs1695) of GSTP1 can impact the binding affinity of these enzymes and/or reduce or eliminate cellular GST activity. [1718] The gene encoding GSTP1 is located at 11q13, spanning nearly 2.8 kb and containing seven exons. [19] GSTP1 plays a critical role in the biotransformation and inactivation of toxic and carcinogenetic electrophiles, especially those in cigarette smoke[20] and also inhibits apoptosis and promotes cellular proliferation through interacting with Jun N-terminal kinase (JNK) pathway.…”