Growth Rate, Early Detection, and Prevention of Melanoma

Lipsker, Dan

doi:10.1001/archderm.142.12.1638

Cited by 32 publications

(7 citation statements)

References 17 publications

(13 reference statements)

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“…Globally, the findings about the GF of CMM support the clinical concept distinguishing CMM of high and low growth rates, each bearing a different prognosis [40–42]. Cancer registries suggested the existence of three unrelated CMM types recognized as (a) thick CMM, with stable incidence over the past decades, (b) thin CMM mainly located on the trunk, and showing a dramatic increase in incidence over the past years, and (c) CMM mainly located on the head and neck region showing a moderate trend in incidence increase over time [43, 44].…”

Section: Immunohistochemistry and Cmm Growth Fractionmentioning

confidence: 86%

Cell Proliferation in Cutaneous Malignant Melanoma: Relationship with Neoplastic Progression

Pierard

2012

ISRN Dermatology

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The establishment of the diagnosis of cutaneous malignant melanoma (CMM) always calls for histopathological confirmation. Further to the recognition of the CMM aspects, immunohistochemistry is helpful, in particular, in determining the size of the replicative compartment and the activity in each of the cell cycle phases (G1, S, G2, M). The involvement of cancer stem cells and transient amplifier cells in CMM genesis is beyond doubt. The proliferation activity is indicative of the neoplastic progression and is often related to the clinical growth rate of the neoplasm. It allows to distinguish high-risk CMM commonly showing a high growth rate, from those CMMs of lower malignancy associated with a more limited growth rate. The recruitment and progression of CMM cells in the cell cycle of proliferation depend on mitogen-activated protein kinase (MAPK) pathway and result from a loss of control normally involving a series of key regulatory cyclins. In addition, the apoptotic pathways potentially counteracting any excess in proliferative activity are out of the dependency of specific regulatory molecular mechanisms. Key molecular components involved in the deregulation of the growth fraction, the cell cycle phases of proliferation, and apoptosis are presently described in CMM.

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Section: Immunohistochemistry and Cmm Growth Fractionmentioning

confidence: 86%

Cell Proliferation in Cutaneous Malignant Melanoma: Relationship with Neoplastic Progression

Pierard

2012

ISRN Dermatology

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“…It has been suggested that thin and thick melanomas are not merely different stages of disease progression but have distinct epidemiologies. 18,19 A recent article by Lipsker reclassifies melanoma into three different subtypes. 19 Type I melanomas are characterized by a fast growth rate, stable incidence, and a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 A recent article by Lipsker reclassifies melanoma into three different subtypes. 19 Type I melanomas are characterized by a fast growth rate, stable incidence, and a poor prognosis. It is hypothesized they are unrelated to sun exposure and do not have mutations in the BRAF gene.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Cutaneous Malignant Melanoma in the Ottawa Region: 1996 to 2006

Nevins

Doucette

et al. 2008

J Cutan Med Surg

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“…Thick tumours, with stable incidence, rapid growth, unpredictable onset, and poor prognosis: this type seems to coincide with the phenotype of "rapidly growing melanomas" [9], or of "thick nodular melanoma" [10] or, from the viewpoint of a busy, coarse practical clinician, "the very melanoma, which has grown so big within few weeks: let's cut it off at once". Such a clinician is not sceptical about depositions of patients testifying that their skin blot has grown rapidly for some weeks and/or was not present before [11]. Of interest, such MMs do not seem to be related to sun exposition, being underrepresented on the trunk and overrepresented on the head and neck skin [3].…”

Section: Type 1 Melanomasmentioning

confidence: 99%

Do "Incidental Melanomas" Exist? If so, how many are they? High Time to Decide

Capella

2019

J. Can. Res. Updates

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Do "Clinically Insignificant, HIstological MElanoma-Like Lesions" (CIHIMELL) -to wit, merely incidental, looking-like-melanoma lesions devoid of intrinsic malignant potential -exist? The question arises from the fact that, in spite of increased diagnoses of completely excised malignant melanoma (MM) in the last two decades, mortality from advanced metastatic disease has not decreased. After a brief review of the literature, the author proposes that the existence of CIHIMELL could be affirmed through post mortem dermoscopy and histological study of any pigmented lesion, clinically or dermoscopically suspected, of several deceased patients undergoing necropsy for death causes unrelated to MM. Should the cumulative prevalence of merely histological melanomas turn out to be exceedingly high and not commensurable with the current death rates of true MM, the discrepancy would tangibly prove that indolent pigmented lesions with morphological aspect of melanoma do exist. This would clearly introduce difficulties that could satisfactorily be dealt with only through a paradigm shift in melanoma surveillance and diagnosis (which could also allow to add a piece of "encouraging uncertainty" to the patient-physician relationship). However, it can be expected that such an enterprise would be countered by several vested academic and commercial interests.

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Growth Rate, Early Detection, and Prevention of Melanoma

Cited by 32 publications

References 17 publications

Cell Proliferation in Cutaneous Malignant Melanoma: Relationship with Neoplastic Progression

Cell Proliferation in Cutaneous Malignant Melanoma: Relationship with Neoplastic Progression

Incidence of Cutaneous Malignant Melanoma in the Ottawa Region: 1996 to 2006

Do "Incidental Melanomas" Exist? If so, how many are they? High Time to Decide

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