Growth in young rats after termination of sodium selenite exposure: Studies of growth hormone and somatomedin C

Comparison of short-term toxicity between Nano-Se and selenite in mice

“…Growth retardation has long been known to be a major characteristic in selenium-intoxicated animals. Se causes growth retardation through reduction in growth hormone and somatomedin C production (Thorlacius-Ussing et al, 1987;Thorlacius-Ussing et al, 1988;Thorlacius-Ussing, 1990) and in insulin-like growth factor-binding proteins and insulin-like growth factor-I (Gronbaek et al, 1995). The U.S. National Research Council concluded in 1976 that growth inhibition might be the best indicator of toxic effects from selenium.…”

Comparison of short-term toxicity between Nano-Se and selenite in mice

“…Growth retardation has long been known to be a major characteristic in selenium-intoxicated animals. Se causes growth retardation through reduction in growth hormone and somatomedin C production (Thorlacius-Ussing et al, 1987;Thorlacius-Ussing et al, 1988;Thorlacius-Ussing, 1990) and in insulin-like growth factor-binding proteins and insulin-like growth factor-I (Gronbaek et al, 1995). The U.S. National Research Council concluded in 1976 that growth inhibition might be the best indicator of toxic effects from selenium.…”

Oral Intake of Selenium Has no Effect on the Serum Concentrations of Growth Hormone, Insulin-Like Growth Factor-1, Insulin-Like Growth Factor-Binding Proteins 1 and 3 in Healthy Women

“…Animal studies have shown that strongly increased blood Se values are associated with decreased serum levels of IGF-1, suggesting that Se may suppress the secretion of growth hormone and/or IGF-1 (8)(9)(10). Our data show, however, that normal or moderately increased serum and blood concentrations of Se (1.3-4.0 μπιοΐ/ΐ), corresponding to a supplementation with wheat Se or selenomethionine in the 100-400 μg range, have no effects on growth hormonQ ,and IGF-1 concentrations in healthy individuals.…”

A Randomized, Double-Blind, Placebo-Controlled Investigation of Selenium Supplementation in Women at Elevated Risk for Breast Cancer: Lessons for Re-Emergent Interest in Selenium and Cancer

“…Nonetheless, we found no evidence to support this hypothesis, i.e., the first scenario mentioned in the preceding paragraph. Relative to the second scenario, an effect on cumulative proliferative load, there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44]. Elevated IGF-1 and IGBP3 have both recently been affirmed to be risk factors for breast cancer [35,36].…”

“…Circulating levels of IGF-1 and its binding protein, IGFBP3, have been linked to breast cell proliferation and breast cancer risk [35,36]. Since there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44], these endpoints were included as study endpoints. The study duration of this randomized, double-blind, placebo-controlled intervention was 12 months with biospecimen collection at baseline, 6, and 12 months during the intervention.…”

Comparison of short-term toxicity between Nano-Se and selenite in mice

“…Growth retardation has long been known to be a major characteristic in selenium-intoxicated animals. Se causes growth retardation through reduction in growth hormone and somatomedin C production (Thorlacius-Ussing et al, 1987;Thorlacius-Ussing et al, 1988;Thorlacius-Ussing, 1990) and in insulin-like growth factor-binding proteins and insulin-like growth factor-I (Gronbaek et al, 1995). The U.S. National Research Council concluded in 1976 that growth inhibition might be the best indicator of toxic effects from selenium.…”

Oral Intake of Selenium Has no Effect on the Serum Concentrations of Growth Hormone, Insulin-Like Growth Factor-1, Insulin-Like Growth Factor-Binding Proteins 1 and 3 in Healthy Women

“…Animal studies have shown that strongly increased blood Se values are associated with decreased serum levels of IGF-1, suggesting that Se may suppress the secretion of growth hormone and/or IGF-1 (8)(9)(10). Our data show, however, that normal or moderately increased serum and blood concentrations of Se (1.3-4.0 μπιοΐ/ΐ), corresponding to a supplementation with wheat Se or selenomethionine in the 100-400 μg range, have no effects on growth hormonQ ,and IGF-1 concentrations in healthy individuals.…”

A Randomized, Double-Blind, Placebo-Controlled Investigation of Selenium Supplementation in Women at Elevated Risk for Breast Cancer: Lessons for Re-Emergent Interest in Selenium and Cancer

“…Nonetheless, we found no evidence to support this hypothesis, i.e., the first scenario mentioned in the preceding paragraph. Relative to the second scenario, an effect on cumulative proliferative load, there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44]. Elevated IGF-1 and IGBP3 have both recently been affirmed to be risk factors for breast cancer [35,36].…”

“…Circulating levels of IGF-1 and its binding protein, IGFBP3, have been linked to breast cell proliferation and breast cancer risk [35,36]. Since there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44], these endpoints were included as study endpoints. The study duration of this randomized, double-blind, placebo-controlled intervention was 12 months with biospecimen collection at baseline, 6, and 12 months during the intervention.…”

Comparison of short-term toxicity between Nano-Se and selenite in mice

“…Growth retardation has long been known to be a major characteristic in selenium-intoxicated animals. Se causes growth retardation through reduction in growth hormone and somatomedin C production (Thorlacius-Ussing et al, 1987;Thorlacius-Ussing et al, 1988;Thorlacius-Ussing, 1990) and in insulin-like growth factor-binding proteins and insulin-like growth factor-I (Gronbaek et al, 1995). The U.S. National Research Council concluded in 1976 that growth inhibition might be the best indicator of toxic effects from selenium.…”

Oral Intake of Selenium Has no Effect on the Serum Concentrations of Growth Hormone, Insulin-Like Growth Factor-1, Insulin-Like Growth Factor-Binding Proteins 1 and 3 in Healthy Women

“…Animal studies have shown that strongly increased blood Se values are associated with decreased serum levels of IGF-1, suggesting that Se may suppress the secretion of growth hormone and/or IGF-1 (8)(9)(10). Our data show, however, that normal or moderately increased serum and blood concentrations of Se (1.3-4.0 μπιοΐ/ΐ), corresponding to a supplementation with wheat Se or selenomethionine in the 100-400 μg range, have no effects on growth hormonQ ,and IGF-1 concentrations in healthy individuals.…”

A Randomized, Double-Blind, Placebo-Controlled Investigation of Selenium Supplementation in Women at Elevated Risk for Breast Cancer: Lessons for Re-Emergent Interest in Selenium and Cancer

“…Nonetheless, we found no evidence to support this hypothesis, i.e., the first scenario mentioned in the preceding paragraph. Relative to the second scenario, an effect on cumulative proliferative load, there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44]. Elevated IGF-1 and IGBP3 have both recently been affirmed to be risk factors for breast cancer [35,36].…”

“…Circulating levels of IGF-1 and its binding protein, IGFBP3, have been linked to breast cell proliferation and breast cancer risk [35,36]. Since there is a small and controversial literature about whether selenium supplementation alters the metabolism of insulin-like growth factor-1 (IGF-1) and its dominant binding protein, IGFBP-3 [37][38][39][40][41][42][43][44], these endpoints were included as study endpoints. The study duration of this randomized, double-blind, placebo-controlled intervention was 12 months with biospecimen collection at baseline, 6, and 12 months during the intervention.…”