2022
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Abstract: Introduction Platelets benefit tissue regeneration by secreting growth factors, and platelet products, for example, platelet lysate (PL), have been clinically applied for tissue rejuvenation. To determine the anti‐ageing efficacy and mechanism of human PL (hPL) on skin, this study conducted clinical retrospective analysis, nude mice‐based in vivo study and human dermal fibroblasts (HDFs)‐based in vitro study. Methods Flow cytometry was employed for quality control of hP… Show more

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Cited by 5 publications
(2 citation statements)
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References 90 publications
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“…The reepithelialization, angiogenesis, and fibroplasia are the main and leading events that happen during this phase 29 . Macrophage-released cytokines, for example, the TGF-β, FGF, and vascular EGF (VEGF) will promote angiogenesis and modulate endothelial cell proliferation 30 . VEGF and receptors play a vital role in regulating angiogenesis and vascular permeability 31 .…”
Section: Discussionmentioning
confidence: 99%
“…The accumulating evidence demonstrates that MI/RI causes myocardial oxidative stress and inflammation, which could eventually trigger apoptosis in the cardiomyocytes [ 6 ]. Mitogen-activated protein kinase (MAPK)/nuclear factor-κB (NF-κB) signaling pathways are involved in the above process of MI/RI [ 7 , 8 , 9 ]. Inflammation might be a significant factor in the whole pathophysiological progression of MI/RI [ 10 ].…”
Section: Introductionmentioning
confidence: 99%