Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes

Abstract

Autologous platelet concentrate contains relatively high concentrations of PDGF-AB, PDGF-BB, TGF-beta1, and IGF-I, but their potential influence on periodontal regeneration remains unclear.

Therapeutic effect of Lianbeijuqin (a Chinese herbal cocktail) on periodontitis in rat

“…Cells (1.5×10 6 ) were seeded in a 48-well plate and cultured for 4 h. Then, the cells were incubated separately with different concentrations of LBJQ (200, 400 and 800 μg/mL) and LPS (100 ng/mL) for another 8 h. Finally, the culture media were collected for assay of TNF-α, IL-1β and IL-6 with commercial ELISA kits.…”

“…Besides tooth loss, periodontitis is associated with other discomforts such as gomphiasis, swelling and aching of gum, fever and bromopnea [3,4]. Current treatment and periodontal tissue regeneration strategies for periodontitis involve scaling, root planning and regenerative surgeries [5,6]. However, strategies for radical treatment of periodontitis are still limited [7].…”

Platelet Rich Plasma in Reconstructive Periodontal Therapy

“…Although it is not well clarified, PRP presents its effects through enhancement of soft and hard tissue healing processes. Since the actual amount of regenerated tissue and the course of soft tissue healing are dependent on the individual healing potential, which is significantly influenced by the presence and amount of the PGFs naturally available in the wound, the increased local concentrations of PGFs with the application of PRP in periodontal wound site enhance the healing outcome (Christgau et al, 2006a). In the early stages of the healing process, PGFs within PRP attract undifferentiated mesenchymal cells within the fibrin matrix and trigger cell division.…”

“…Furthermore, it is very difficult and expensive to use such materials when full mouth bone defects are present. The ability to incorporate PGFs into the periodontal wound healing site with the application of PRP provides a promising approach to reach the established regenerative goals (Christgau et al, 2006a(Christgau et al, , 2006b. It is also possible to treat multiple intrabony defects in the same mouth with PRP prepared with the blood drawn from the same patient.…”

“…An animal experimental study provides an evidence of the positive role of PPP as a potential osteoinductive biologic tissue adhesive (Abiraman et al, 2002). In a recent animal study, it has been shown that PPP enhances bone formation based on radiographic and histologic findings (Findikcioglu et al, 2009 (Christgau et al, 2006a). Other than growth factors, it was also suggested that because of its fibrinogen content PRP reacts with thrombin to induce fibrin clot formation (Camargo et al, 2005).…”