Growth characterization in a cohort of renal allograft recipients

Rico, Mayerly Prada; Hernandez, Monica Fernandez; Castellanos, Marcela C.; Agredo, Olga Lucía Prado; Carvajal, Alejandra Pedraza; Chaparro, Luz E. González; Amaya, Ricardo Gastelbondo; Viveros, Carlos Andrés Benavides

doi:10.1111/petr.13632

Cited by 1 publication

(4 citation statements)

References 28 publications

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“…[Zm1]The above clinical characteristics are consistent with previous reports [1,[13][14][15][16][17] . Data from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) annual report [14] reported that the mean Ht-SDS was -1.4 in a cohort of over 1500 patients aged 19 years or more, with 25% of these patients having a Ht-SDS of -2.3 or worse and 10% being below -3.3.…”

Section: Ht-sds At Last Follow-upsupporting

confidence: 88%

“…In our study 28.8% recipients couldn't met the lower normal limit of height[Zm2] (Ht-SDS <-2), and 64 patients (57.7%) had a height score below -1. Previous other centers reports [15][16]18] showed that the percentage of patients who achieved a normal final height (third centile) ranged from 42 to 75%, as reported in previous studies 62-77% of patients exhibited growth failure at 18 years of age or more.…”

Section: Ht-sds At Last Follow-upsupporting

confidence: 64%

“…Monitoring indicators were measured at average levels during the whole follow-up period. by 20%-48% recipients is not the target height [6][7][8][9][10][13][14][15][16] . In our study pediatric recipients occurred height catch-up growth in the 1 st year after KT with chase rate 47.7%, younger children with more catch-up potential (patient age at KT:<9 years old was 68%,>9 years old was 31%).…”

Section: Ht-sds At Last Follow-upmentioning

confidence: 97%

“…The last follow-up Ht-SDS is affected by baseline Ht-SDS and ∆Ht-SDS. The factors that can affect the baseline Ht-SDS, such as maintenance dialysis duration before transplantation, renal function, serum albumin and serum phosphorus levels of related nutrition, can affect the endpoint Ht-SDS [1,[13][14][15][16][17][18] ,…”

Section: Ht-sds At Last Follow-upmentioning

confidence: 99%

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Catch-up growth of children with graft survival after kidney transplantation: A cohort study

Zhang

Zhong

et al. 2023

Preprint

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Objective: To describe and explore the clinical characteristics and associated factors of growth in children after kidney transplantation (KT). Method: Retrospective study was performed on the clinical data of 111 children who underwent allogeneic KT and met the inclusion criteria (provided by Guangzhou Women and Children’s Medical Center and the Sun Yat-sen University First Affiliated Hospital). Catch-up growth was defined as present if the increment of height standard deviation score (∆Ht-SDS) was ≥0.5 per year. Described the clinical characteristics and compared possible associated factors between children with catch-up growth and no catch-up growth groups. Result: The median age at KT was 9(6,12) years, and 54.1% (60/111) are females. Mean height-SDS before KT was -2.14±1.29, 55.9% (62/111) showed growth retardation. Catch-up growth within the first years post-KT was present in 47.7% (53/111) recipients, the mean ∆Ht-SDS was 0.53±0.71. The Ht-SDS before KT was positively associated with last follow-up Ht-SDS (R=0.78, P<0.001). The baseline Ht-SDS, transplantation age, serum creatinine, and GC dose were significantly lower in the chase group (all P≤0.05), multivariate logistic regression analysis indicated that lower baseline Ht-SDS and serum creatinine were the protect factors for catch-up growth on the 1st year of post-transplantation (OR=0.62, 0.97, respectively, P<0.05). The last follow-up Ht-SDS affected by baseline Ht-SDS and ∆Ht-SDS. HtSDS was no statistical difference among different age groups (patient age at KT: <6years,6-9 years,9-12years,>12years), but ∆Ht-SDS showed significant difference between groups (0.74±0.80, 0.82±0.73, 0.28±0.67, 0.32±0.47, respectively, P<0.05). Younger Children showed significant catch-up rate after KT(<9years:68%,>9years:31%), however the ∆Ht-SDS was decrease in the second year (P<0.05). Conclusion: Growth assessment and management should be performed in any pediatric KT recipients. Even in younger children with more catch-up potential, ∆Ht-SDS decreased significantly at second year, growth continues to be suboptimal after KT. Given that baseline ∆Ht-SDS is a significantly associated factor, it is important for children with severe growth retardation need early identification and plan interventions in terms of growth improvement. We expected the children recipients achieved the ideal target height of post-transplantation.

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