To evaluate the effect of four agricultural practices on grain yield, two varieties (IT-16 and IT-18) of cowpeas were tested in the agricultural year 2016/2017 an experimental field where the following agricultural practices were tested: tillage, tillage + mulch, zero tillage and zero tillage + mulch. The randomized complete blocks design, a scheme consisting of two factors: agronomic practices and varieties was used. The plant height, number of pods per plant, weight of 100 seeds and grain yield in kg ha-1 were considered as parameters for analysis. From the results, it was concluded that for the yield of grain of different varieties under study, the variety IT-18 subjected to zero tillage + mulch and the variety IT-16 subjected to tillage had better performance achieving 2600.00 kg ha-1 and 1725.00 kg ha-1 respectively; therefore, recommended to the farmers.