Group B Streptococcus: Prevention of Early-Onset Neonatal Sepsis

Platt, Julie; O’Brien, William F.

doi:10.1097/01.ogx.0000050764.67701.8c

Cited by 16 publications

(13 citation statements)

References 49 publications

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“…When a patient is allergic to penicillin, the choices recommended by the CDC are erythromycin and clindamycin. Like other authors, we found that resistance to erythromycin and clindamycin was increasing among GBS [18], so it would be useful to test for antibiotic sensitivity, especially for penicillin-allergic women. Due to antibiotic abuse in the past, there has been an increase in resistant strains of microorganisms, which causes great concern about the restriction of antibiotics.…”

Section: Discussionsupporting

confidence: 80%

Antibiotic Susceptibility Pattern of Anovaginal Isolates of Streptococcus agalactiae from Pregnant Women in Their Late Third Trimester

Lin

Huang

et al. 2004

The Kaohsiung J of Med Scie

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Group B streptococcus (GBS) neonatal sepsis is a serious disease causing newborn mortality and long‐term neurologic sequelae. The Centers for Disease Control and Prevention (CDC) recommend third‐trimester GBS screening and intrapartum antibiotic prophylaxis for high‐risk women. The aim of our study was to identify colonized pregnant women and assess the prevalence of GBS in pregnancy and the susceptibility pattern of GBS in southern Taiwan. We performed the study at the Department of Obstetrics and Gynecology, Kaohsiung Women and Children' Hospital, between January and December 2002. Distal vaginal and anorectal swabs were obtained from pregnant women at 35 or more weeks' gestation. Swabs were used to inoculate selected medium, which was subcultured onto sheep' blood agar after 24 hours. Sensitivity to azithromycin, clindamycin, erythromycin, ofloxacin, penicillin G, tetracycline, trimethoprim/sulfamethoxazole, and vancomycin was tested using the disc diffusion method. Of the 374 pregnant women enrolled in the study, 56 (15%) had positive cultures for GBS. Antibiotic susceptibility was as follows: azithromycin 44.6%, clindamycin 66.1%, erythromycin 70.5%, ofloxacin 70.5%, penicillin G 60.7%, tetracycline 39.3%, trimethoprim/sulfamethoxazole 35.7%, and vancomycin 100%. The CDC recommend penicillin as the first choice for intrapartum prophylaxis, with erythromycin and clindamycin as alternatives for penicillin‐allergic patients. There has been increasing resistance to these antibiotics among GBS. Third‐trimester GBS screening and susceptibility testing for pregnant women should be considered.

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Section: Discussionsupporting

confidence: 80%

Antibiotic Susceptibility Pattern of Anovaginal Isolates of Streptococcus agalactiae from Pregnant Women in Their Late Third Trimester

Lin

Huang

et al. 2004

The Kaohsiung J of Med Scie

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“…[21][22][23][24][25][26] Our incidence of non-GBS organisms did not change, and intrinsically resistant species such as enterococcus and enterobacteria species did not increase either. There was no increased incidence of infection from penicillin-resistant bacteria; nor any loss of GBS sensitivity to penicillin.…”

Section: Discussionmentioning

confidence: 66%

Institution of universal screening for Group B streptococcus (GBS) from a risk management protocol results in reduction of early‐onset GBS disease in a tertiary obstetric unit

Angstetra

Ferguson

Giles

2007

Aust NZ J Obst Gynaeco

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“…GBS infection was first reported in 1938 1 . By 1970, it had increased dramatically and became the leading cause of neonatal death and an important cause of maternal infection.…”

Section: Discussionmentioning

confidence: 99%

Mother with post‐partum group B Streptococcus meningitis and cerebellar abscess

Ghani¹,

Jaafar²,

Ishak³

et al. 2007

J of Obstet and Gynaecol

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We report the case of a 25-year-old Malay woman, admitted for preterm delivery at 35 weeks' gestation. Vaginal swab did not isolate any organism. She delivered a baby girl who developed respiratory distress syndrome, requiring ventilation. Although chest radiograph showed hyaline membrane disease with pneumonia, septic workout was negative. The mother was discharged on the next day. Seven days postpartum, the mother presented with fever and fits and was diagnosed to have meningo-encephalitis. Lumbar puncture isolated group B Streptococcus (GBS) and MRI revealed a superior cerebellar abscess. She was treated and survived the episode. This case illustrates the uncommon situation where GBS infection was confirmed via maternal septic workout rather than neonatal, although both presented with severe disease.

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Group B Streptococcus: Prevention of Early-Onset Neonatal Sepsis

Abstract: After completion of this article, the reader will be able to define the pathogen, describe the methods of transmission and detection, and outline the current recommendations for maternal group B streptococcus therapy.

Cited by 16 publications

References 49 publications

Antibiotic Susceptibility Pattern of Anovaginal Isolates of Streptococcus agalactiae from Pregnant Women in Their Late Third Trimester

Antibiotic Susceptibility Pattern of Anovaginal Isolates of Streptococcus agalactiae from Pregnant Women in Their Late Third Trimester

Institution of universal screening for Group B streptococcus (GBS) from a risk management protocol results in reduction of early‐onset GBS disease in a tertiary obstetric unit

Mother with post‐partum group B Streptococcus meningitis and cerebellar abscess

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