Group B streptococcal colonization and the risk of pre-eclampsia

Mulla, Zuber D.; Annavajjhala, Vidhya; González-Sánchez, José Luis; Simon, Michael R.; Nuwayhid, B.

doi:10.1017/s0950268812001598

Cited by 5 publications

(12 citation statements)

References 34 publications

(35 reference statements)

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“…The study reached the same conclusion found in the early 2000’s report using statewide hospital databases in Florida and Texas [26]. Interestingly, our study population had a much greater reduction (59%) than was found for the Florida (27%) and Texas (30%) cohorts.…”

Section: Discussionsupporting

confidence: 90%

“…There was no correlation between GBS colonization and incidence of preeclampsia. The overall GBS colonization and preeclampsia rates were much higher than those found in the present study and in the Florida/Texas cohorts study [26]. It is not clear if the 35% black patients, or the other race/ethnic groups present (44% white, 21% unknown) contributed to such high GBS colonization and preeclampsia rates.…”

Section: Discussioncontrasting

confidence: 89%

“…Regarding the two previously cited case studies where GBS colonization was not correlated with preeclampsia, a likely explanation is the differences in race and geographic locations. In the case-control study of 330 patients at El Paso [7], only 1.5% of the patients were black (the rest were mostly Hispanic white), and only 8.5% of the total 330 of patients were GBS colonized (less than the 12.5% in our study; 12.3% in Florida cohort; 14.1% in Texas cohort [26]). The study of 60,029 patients at Duke Health affiliated hospitals 5 contained 35% black patients, a GBS colonization rate of 21.6%, and a preeclampsia rate of 11.6%.…”

Section: Discussionmentioning

confidence: 66%

“…One possible explanation is that the denominators, the preeclampsia rates among the GBS negative patients, were lower in the Florida (3.8%) and Texas cohorts (4.2%) than in our study (6.7%), while the numerators, the preeclampsia rates for GBS colonized patients in Florida and Texas (2.8% and 2.9%), were similar to that in our study (2.7%). The higher rate of preeclampsia among our GBS negative patients compared with such patients in the Florida and Texas cohorts is not surprising as the patients in our study were mostly African Americans (93%), whereas African Americans comprised just 22% of the Florida cohort and 12% of the Texas cohort [26]. African American women are known to have a high risk of preeclampsia compared with other races [9].…”

Section: Discussionmentioning

confidence: 93%

See 3 more Smart Citations

Maternal Infection with Group B Streptococcus Correlates Inversely with Preeclampsia in Pregnant African American Women

Kwon

Cheng

Zhou

et al. 2023

Preprint

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Objective: Preeclampsia is more prevalent in African American women than other races. GBS colonization rate in African American women is the highest among different races. We hypothesized there is an association between GBS colonization and preeclampsia among pregnant African American women. Study Design: We evaluated the relationship between GBS colonization and preeclampsia in 11,766 patients records (93% were African Americans patients) between 2010 and 2017. Results: The preeclampsia rate of GBS colonized patients (2.6%) was 59% less than that of GBS-negative patients (6.3%). This inverse correlation was independently significant after adjusting for other potential risk factors for preeclampsia: chronic hypertension, gestational diabetes mellitus and diabetes mellitus and other covariates. Further analysis among the patients without these risk factors also confirmed that the preeclampsia rate of GBS colonized patients (2.6%) was 55% less than that of GBS negative patients (5.7%). Similarly, patients with HSV+ or HIV+ had lower incidence of preeclampsia than those with HSV- or HIV-. Conclusions: The unexpected finding of an inverse relationship between GBS colonization and preeclampsia suggests that the maternal immune response to GBS infection may be beneficial in reducing preeclampsia among African American patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 93%

See 2 more Smart Citations

Maternal Infection with Group B Streptococcus Correlates Inversely with Preeclampsia in Pregnant African American Women

Kwon

Cheng

Zhou

et al. 2023

Preprint

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“…The experimental result indicated a decreased number of Streptococcus species in the PE group, thus suggesting that Streptococcus bacteria may be correlated with the occurrence of PE (Chang et al 2020 ). Other research (Mulla et al 2013 ) has suggested that Streptococcus may be associated with tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and other cytokines. Streptococcus induced TNF-α (Zaga et al 2004 ; Kwak et al 2000 ; Rosati et al 1998 ; Hunolstein et al 1997 ) and IL-6 (Zaga et al 2004 ; Kwak et al 2000 ; Rosati et al 1998 ).…”

Section: Discussionmentioning

confidence: 99%

The causal role of intestinal microbiome in development of pre-eclampsia

Xiong

Wang

Pei

et al. 2023

Funct Integr Genomics

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The correlation of pre-eclampsia (PE) and intestinal microbiome has been widely demonstrated in existing research, whereas their causal relationship has been rarely explored. The causal relationship between intestinal microbiome and PE risk was examined using large-scale genome-wide association studies (GWAS) summary statistics. To be specific, the causal microbial taxa for PE were identified using the two-sample Mendelian randomization (MR) method. The results were verified to be robust through comprehensive sensitive analyses, and the independence of causal relationship was ensured through novel multivariable MR analyses. The possibility of reverse relationships was ruled out through reverse-direction MR analyses. Lastly, the biofunction was explored through enrichment analysis, and a series of validations of PE results in a second GWAS were performed to confirm the results. After correction, four microbial taxa, including Streptococcus genus for PE (FDR q = 0.085), Olsenella genus for PE (FDR q = 0.085), Enterobacteriales order for PE (FDR q = 0.0134), and Akkermansia genus for PE (FDR q = 0.015), had a causal relationship to diverse joint PE (FDR q < 0.15). Moreover, when three different methods were employed on basis of the nominal significance (P < 0.05), five suggestive microbial taxa took on significance. The effect of heterogeneity and horizontal pleiotropy was excluded through sensitive analysis, and the possibility of horizontal pleiotropy of BMI was ruled out through multivariable MR analysis. The protective mechanism of the identified taxa against PE was illustrated through GO enrichment analysis and KEGG pathways. A number of microbial taxa had a causal relationship to PE. The result of this study provides more insights into intestinal microbiome in the pathology of PE.

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