2021
DOI: 10.1186/s12877-021-02411-7
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Abstract: Background Grip strength is an indicator of physical function with potential predictive value for health in ageing populations. We assessed whether trends in grip strength from midlife predicted later-life brain health and cognition. Methods 446 participants in an ongoing British birth cohort study, the National Survey of Health and Development (NSHD), had their maximum grip strength measured at ages 53, 60–64, and 69, and subsequently underwent ne… Show more

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Cited by 18 publications
(16 citation statements)
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“…This study did show a reduction in cognition in persons with sarcopenia defined by low muscle mass. Another study of 446 participants from the British birth cohort study found lower whole brain volume and lower score on matrix reasoning, a measure of non-verbal abstract reasoning, with lower grip strength [41]. A Freesurfer-based volumetric MRI study of 26 persons with lower grip strength and 26 matched healthy controls found lower volumes of hippocampal sub-regions right CA1, bilateral presubiculum, the left parasubiculum, left molecular layer, and left hippocampal amygdala transition area [42].…”
Section: Discussionmentioning
confidence: 99%
“…This study did show a reduction in cognition in persons with sarcopenia defined by low muscle mass. Another study of 446 participants from the British birth cohort study found lower whole brain volume and lower score on matrix reasoning, a measure of non-verbal abstract reasoning, with lower grip strength [41]. A Freesurfer-based volumetric MRI study of 26 persons with lower grip strength and 26 matched healthy controls found lower volumes of hippocampal sub-regions right CA1, bilateral presubiculum, the left parasubiculum, left molecular layer, and left hippocampal amygdala transition area [42].…”
Section: Discussionmentioning
confidence: 99%
“…A growing body of evidence supports the contributing role of sociodemographic, physical, and psychological health and wellbeing in interindividual differences in brain structure. For example, a weaker grip strength in midlife have been linked to a smaller whole brain volume in later life (aged 69–71 years) [ 14 ], while greater brain atrophy has been identified in people with depression or poor metabolic health [ 15, 16 ]. The protective effect of a higher educational attainment on brain volume has also been identified in older individuals cross-sectionally [ 17, 18 ] and may be an initial advantage that carries into later life [ 18, 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…8 In view of its power to anticipate impairments that may only become evident several years later, there have been recommendation that measurements of grip strength be used to identify older adults at risk of neurological degeneration and cognitive decline (for example,. [9][10][11] ) Morphometric factors, including height, body-mass, and hand size also contribute to individual differences in grip strength. They do so independently of variations in brain health that account for the associations between grip strength and cognition seen in large cohort studies.…”
Section: Introductionmentioning
confidence: 99%