Grey‐scale analysis allows a quantitative evaluation of thyroid echogenicity in the patients with Hashimoto's thyroiditis

Mazziotti, Gherardo; Sorvillo, Francesca; Iorio, Sergio; Carbone, Antonella; Romeo, Antonio; Piscopo, Marco; Capuano, Salvatore; Capuano, Ernesto; Amato, Giovanni; Carella, Carlo

doi:10.1046/j.1365-2265.2003.01829.x

Cited by 71 publications

(81 citation statements)

References 24 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to minimize the operator variability in assessing thyroid echogenicity, only those scans performed by the same operator (S C), who was well trained and had a 5-year experience in thyroid imaging, were selected. According to previous studies, echogenicity was evaluated in both thyroid lobes and in the surrounding neck muscles on the transverse section (12,16). The isthmus was excluded to avoid the interference of reflecting echoes from the tracheal cartilage.…”

Section: Thyroid Usmentioning

confidence: 99%

“…The isthmus was excluded to avoid the interference of reflecting echoes from the tracheal cartilage. Hypoechogenicity was ascertained by comparison of the echo distribution in the thyroid parenchyma with respect to the surrounding neck muscles, and only those scans showing mild to severe generalized hypoechogenicity were selected (12,16).…”

Section: Thyroid Usmentioning

confidence: 99%

“…Rapid improvements in US equipment and the use of standardized computerized algorithms have permitted an objective and quantitative measurement of tissue echogenicity in thyroid diseases (11)(12)(13), as well as in other pathological conditions (14,15). Using a subjective measure of thyroid echogenicity, previous studies demonstrated that in patients with thyroid autoimmune diseases, the presence of circulating thyroid antibodies (Abs) as well as the development of hypothyroidism was closely correlated with the degree of thyroid hypoechogenicity (1,5,11,12,16).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity

Rotondi¹,

Cappelli²,

Leporati³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Thyroid ultrasound (US) scan is a valuable tool for diagnosing thyroid diseases. In autoimmune thyroid disease (AITD), an hypoechoic pattern of the thyroid at US is related to circulating thyroid antibodies (Abs). The aim of this study was to evaluate the diagnostic accuracy of thyroid US for the detection of AITD in patients with morbid obesity. Design: Thyroid US scans showing an hypoechoic pattern of the thyroid were collected from 105 morbid obese patients (body mass index (BMI) O40 kg/m 2 ) and 105 non-obese patients (BMI%30 kg/m 2 ). Results: A thyroid hypoechoic pattern at US was consistent with clinical/biochemical features of AITD in 90/105 (85.7%) non-obese patients and in 22/105 (20.9%) morbid-obese patients (P!0.0001). By performing a complete thyroid work-up, including clinical examination, thyroid morphology, serum hormones, and auto-Ab measurements, the discrepancy between the US pattern and the results of the thyroid Ab tests was justified in 6/15 non-obese patients, and only in 1/83 morbid obese patients. Thus, an unexplained hypoechoic pattern of the thyroid at US, defined as negative tests for thyroid Ab and absence of justifying thyroid disturbances, was found in 2/105 (1.9%) non-obese patients and in 68/105 (64.8%) morbid obese patients (P!0.0001). Conclusions: Our results suggest that i) morbid obesity may affect thyroid morphology, and ii) an hypoechoic pattern of the thyroid at US, a well-established parameter for diagnosing AITD, has a poor diagnostic accuracy when patients with morbid obesity are taken into account.

show abstract

Section: Thyroid Usmentioning

confidence: 99%

Section: Thyroid Usmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity

Rotondi¹,

Cappelli²,

Leporati³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Since subclinical thyroid dysfunction has a tendency to develop into overt thyroid dysfunction (4), the finding of decreased echogenicity or irregularity in echo pattern at thyroid US in these patients with the elevation of thyroid-stimulating hormone (TSH) could perhaps be seen as an early sign of thyroid failure. Most previous studies concern patients with known Hashimoto's thyroiditis (1,3,(5)(6)(7)(8)(9) or patients referred to a hospital with suspicion of thyroid disease (10,11). One study (2) concerns apparently healthy subjects from hospital staff.…”

Section: Introductionmentioning

confidence: 99%

The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population

Vejbjerg¹,

Knudsen²,

Perrild³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

Objective: Patients with overt hypothyroidism show decreased echogenicity of the thyroid at ultrasonography (US). The aim of this study was to investigate the association between echogenicity of the thyroid/irregular echo pattern, and thyroid function in the general population, i.e. subjects without overt thyroid disease. Design: A cross-sectional investigation of 4649 randomly selected adult subjects. Methods: Blood samples were analysed for serum TSH, thyroid hormones and thyroid autoantibodies. US of the thyroid was performed. Results: Participants with decreased echogenicity (nZ379) had a higher mean TSH (1.65 mU/l) compared with subjects with normal echogenicity (1.21 mU/l, P!0.0001). The association was stronger in subjects with markedly decreased echogenicity (4.20 mU/l, P!0.0001). A similar association was seen when the subjects were divided into subgroups according to the level of TSH; more subjects with high levels of TSH had decreased echogenicity (P!0.0001). Likewise, more subjects with high levels of TSH had an irregular echo pattern (P!0.0001). Subjects with decreased echogenicity had a higher risk of having thyroid autoantibodies than subjects without decreased echogenicity (P!0.0001). This association was stronger when echogenicity was markedly decreased. Conclusions: We demonstrated an association between hypoechogenicity at thyroid US and higher levels of serum TSH even in subjects without overt thyroid disease, suggesting decreased echogenicity as an early sign of thyroid dysfunction. Irregular echo pattern, whether accompanied by hypoechogenicity or not, was another possible marker of thyroid failure. This indicates a possible use of thyroid US in detecting early and subclinical thyroid dysfunction.European Journal of Endocrinology 155 547-552

show abstract

“…Der Nachweis von Schilddrüsenautoantikörpern, welche gegen das Enzym Thyreoperoxidase, beziehungsweise gegen das Protein Thyreoglobulin gerichtet sind, gehört, neben dem sonographischen Nachweis eines echoarmen (126,(146)(147)(148)(149)(150) …”

Section: Schilddrüsenautoantikörperunclassified

Kohlenhydratmalassimilation bei der Hashimoto-Thyreoiditis

Heckl¹,

Schafer²,

Dick³

et al. 2012

Z Gastroenterol

View full text Add to dashboard Cite

show abstract

Grey‐scale analysis allows a quantitative evaluation of thyroid echogenicity in the patients with Hashimoto's thyroiditis

Cited by 71 publications

References 24 publications

A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity

A hypoechoic pattern of the thyroid at ultrasound does not indicate autoimmune thyroid diseases in patients with morbid obesity

The association between hypoechogenicity or irregular echo pattern at thyroid ultrasonography and thyroid function in the general population

Kohlenhydratmalassimilation bei der Hashimoto-Thyreoiditis

Contact Info

Product

Resources

About