Greenish Pigmentation of Nail Plates From Bacillus Pyocyaneus Infection

Goldman, Leon

doi:10.1001/archderm.1944.01510080048014

Cited by 22 publications

(15 citation statements)

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“…Dyschromien der Nagelplatte werden durch eine Reihe von Erregern, v. a. durch gramnegative Bakterien hervorgerufen. Am bekanntesten ist die Grünver-färbung der Nägel durch Pseudomonas aerugenosa, über die schon seit den 40er-Jahren berichtet wird [2,7,9,16,23]. Diese Bakterien bilden Pyocyanin, das von der Nagelplatte aufgenommen wird und diese grünlich verfärbt.…”

Section: Besprechungunclassified

Ungues nigri durch Proteus mirabilis

Qadripur¹,

Schauder²,

Schwartz

2001

Der Hautarzt

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Black nails caused by Proteus mirabilis were seen in a motor mechanic and in a petrol pump attendant. Proteus mirabilis is a gram-negative bacillus that generates hydrogen sulfide. This compound reacts with traces of metals in the nail plate such as zinc, nickel, cobalt, iron, manganese, tin, copper and lead. Metal sulfides blacken the nail plate. The protracted course of the discoloration over months corresponds to the slow reactions of metals with hydrogen sulfide. The disappearance of the blackening after topical treatment with chinosol, tincture of iodine and chloramphenicol solution supports the etiologic connection between black nails and Proteus mirabilis. Wet and dirty work encourages the colonisation of Proteus mirabilis between nail fold and nail plate.

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Section: Besprechungunclassified

Ungues nigri durch Proteus mirabilis

Qadripur¹,

Schauder²,

Schwartz

2001

Der Hautarzt

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“…It is salient that a Shanghai study documented, without commenting on pseudomonas nail infections in health care workers, that 80% of 61 patients hospitalized in the intensive care unit for a COVID-19 acute respiratory infection had bronchial aspirates positive for P aeruginosa. 4 Persistent greenish pigmentation of the nail plate, originally described in 1944 by Goldman and Fox, 5 should be viewed as a warning sign. 3,6,7 This nontender paronychial infection is predisposed to by those whose hands are constantly wet ( Figure 1).…”

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confidence: 99%

The Goldman‐Fox syndrome: Treating and preventing green pseudomonas nails in the era of COVID ‐19

Schwartz

Kapila

2020

Dermatologic Therapy

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The Goldman-Fox syndrome, also referred to as the green nail syndrome, was recently spotlighted for its possible association with onychomycosis. 1,2 However, there may be more to the Goldman-Fox syndrome than a Pseudomonas aeruginosa infection of a nail plate often previously damaged by dermatophytes, psoriasis or trauma. 3 This opportunistic bacterium known as the "water bug," P aeruginosa, can produce both localized and systemic infections and be spread cryptically, potentially from the infected nail of a caregiver to a wound or surgical site, and thus represents a potential threat to elderly, neonatal or immunocompromised patients who are at an increased risk of disseminated pseudomonas infection. This pathogen is known to cause pneumonia, endocarditis, otitis externa, urinary tract infections, osteomyelitis and sepsis and also may be evident in skin as necrotizing fasciitis or as ecthyma gangrenosum, the latter a sign of pseudomonas sepsis. It is salient that a Shanghai study documented, without commenting on pseudomonas nail infections in health care workers, that 80% of 61 patients hospitalized in the intensive care unit for a COVID-19 acute respiratory infection had bronchial aspirates positive for P aeruginosa. 4

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“…Dermatology Review/Przegląd Dermatologiczny 2020/6 introduction Nail plate alterations are often observed in the elderly population and can be a sign of an infection or underlying systemic disease [1][2][3][4]. One of the most common nail disorders is fungal infection [5], but other pathogens should also be considered during the diagnostic process.…”

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confidence: 99%

“…One of the most common nail disorders is fungal infection [5], but other pathogens should also be considered during the diagnostic process. Greenish discoloration of the nail plate was first described and linked to be caused by Pseudomonas aeruginosa by Goldman and Fox [4], hence this condition is named Goldman-Fox Syndrome (GFS) as well as chloronychia or green nail syndrome (GNS).…”

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Onycholysis associated with green nail dyschromia

Muth¹,

Królik²,

Kubisiak-Rzepczyk³

et al. 2020

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Introduction. Green nail syndrome is a condition caused by the Pseudomonas aeruginosa infection. It is most often reported in patients with predisposing conditions that favour the growth of this pathogen such as constant exposure of the hands to water, soaps and detergents, especially in elderly persons. Objective. The aim of this study is to present a case of the green nail syndrome in an elderly patient and bring attention to the greenish colour of the nails as a warning sign of the Pseudomonas aeruginosa infection. Case report. An 88-year-old woman with asymptomatic green-yellowish changes on fingernail plates accompanied by onycholysis. The examination for fungal infection was negative, whereas the bacteriological culture of the nail was positive for Pseudomonas aeruginosa. Conclusions. Green coloration of the nails should be a warning sign of the Pseudomonas aeruginosa infection. Treatment with oral ciprofloxacin, especially in elderly patients could be a valuable option for treating the green nail syndrome. streszczenie Wprowadzenie. Zespół zielonych paznokci wywoływany jest przez zakażenie bakterią Pseudomonas aeruginosa. Występuje najczęściej wśród pacjentów w podeszłym wieku, u których stwierdza się czynniki predysponujące do rozwoju tej jednostki chorobowej, takie jak stała ekspozycja rąk na wodę, środki myjące i detergenty. Cel pracy. Celem pracy jest przedstawienie przypadku klinicznego zespołu zielonych paznokci u osoby w podeszłym wieku i zwrócenie uwagi na charakterystyczne zielonkawe zabarwienie paznokci jako objaw, który może wskazywać na zakażenie Pseudomonas aeruginosa. Opis przypadku. Osiemdziesięcioośmioletnia pacjentka zgłosiła się z zielonożółtym zabarwieniem płytki paznokciowej na kilku palcach ręki. Objawowi temu towarzyszyła onycholiza. Wynik badania mykologicznego był ujemny, natomiast w hodowli bakteriologicznej uzyskano Pseudomonas aeruginosa.

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Greenish Pigmentation of Nail Plates From Bacillus Pyocyaneus Infection

Cited by 22 publications

References 1 publication

Ungues nigri durch Proteus mirabilis

Ungues nigri durch Proteus mirabilis

The Goldman‐Fox syndrome: Treating and preventing green pseudomonas nails in the era of COVID ‐19

Onycholysis associated with green nail dyschromia

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