Green synthesis of phytochemical-stabilized Au nanoparticles under ambient conditions and their biocompatibility and antioxidative activity

Abstract

Green chemical synthesis of Au nanoparticles (NPs) has been of great interest because of its potential biomedical applications. In this study, we successfully produced phytochemical-induced Au NPs cofunctionalized with gallic acid, protocatechuic acid, and isoflavone. They have a strong antioxidant effect and serve as effective reducing agents, inducing the immediate passivation of Au NPs. The properties of these green chemical Au NPs were characterized by TEM, UV/Vis and FT-IR spectroscopy, and z-potential measurements, and the Au NPs exhibited excellent homogeneity with an average diameter of 20 nm and high dispersity at all pH ranges, with long-term stability as well as excellent cytocompatibility. Molecular dynamics (MD) simulations were also carried out in order to reveal the surface stability of the Au NPs. The computational results indicate that there are strong interactions between the phytochemicals and Au NPs, especially in the Au/protocatechuic acidisoflavone model. Phytochemical-stabilized Au NPs allowed about 40% H 2 O 2 to be removed at an NP concentration of 50 mg mL À1 ; this removal rate is the same as that achieved by 3000 units per mg catalase. Therefore, this novel synthesis route for Au NPs using phytochemical reducing agents may be effectively exploited for nonthermal-assisted reactions and one-pot processes of biological applications.

Seaweed-mediated biosynthesis of silver nanoparticles using Gracilaria corticata for its antifungal activity against Candida spp.

“…5b. This may be achieved by means of high repulsive and attractive forces exist between each nanoparticle (Lee et al 2011). The observed result is well correlated with the TEM studies (Fig.…”

Biosynthesis of Silver Nanoparticles by Chaetomorpha antennina (Boryde Saint-Vincent) Kutzing with Its Antibacterial Activity and Ecological Implication

“…The zeta potential value of Ag Nanoparticles, -31.4 mV, indicated the high stability of AgNanoparticles (Figure 9), it may be due to the high repulsive and attractive force exist between Nanoparticles [24] The similar study had been reported for biosynthesized Silver Nanoparticles by Gracilaria corticata, zeta potential was -26.2 mV [25].…”

Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups

“…The nanoparticles might penetrate into the cell via endocytotic mechanisms such as phagocytosis, pinocytosis, nonspecific endocytosis, receptor-mediated endocytosis, etc. 47,48 TEM studies were also performed to track a detailed cellular uptake of SPIONs ( Figure 5B). The internalization of SPIONs is highly related to their coating material, shape, and size.…”