2020
DOI: 10.1111/jphp.13274
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Abstract: Objectives Synthesizing and characterization of gold nanoparticles (Au NPs) by Ferula persica gum essential oil and investigating in vitro anti-cancer effects. Methods Characterization of NPs was performed. Cytotoxicity and apoptosis were determined on cancerous CT26 and non-cancerous Vero cells using MTT assay and acridine orange/ethidium bromide (AO/EB) staining, respectively. Clonogenic assay was also performed. … Show more

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Cited by 30 publications
(13 citation statements)
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“…The analgesic effect of the essential oil is thought to be either due to its action on acetic acidsensitive visceral receptors or inhibition of synthesis and action of prostaglandins and also cyclooxygenase and/or lipoxygenase in the arachidonic acid cascade at the peripheral route. Hosseinzadeh et al,(2020a), Hosseinzadeh et al,(2020b) performed the synthesis of gold nanoparticles using essential oil obtained from the gum of F. persica Willd. and evaluated their in vitro anticancer effects.…”
Section: Antinociceptive and Hyperalgesia Effectmentioning
confidence: 99%
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“…The analgesic effect of the essential oil is thought to be either due to its action on acetic acidsensitive visceral receptors or inhibition of synthesis and action of prostaglandins and also cyclooxygenase and/or lipoxygenase in the arachidonic acid cascade at the peripheral route. Hosseinzadeh et al,(2020a), Hosseinzadeh et al,(2020b) performed the synthesis of gold nanoparticles using essential oil obtained from the gum of F. persica Willd. and evaluated their in vitro anticancer effects.…”
Section: Antinociceptive and Hyperalgesia Effectmentioning
confidence: 99%
“…The cytotoxicity of gum essential oil from F. persica Willd. on Vero cell lines and murine colon carcinoma (CT26) was demonstrated by MTT assay (Hosseinzadeh et al, 2020a;Hosseinzadeh et al, 2020b). The primary component of the essential oil was alpha-pinene (27%), (Z)-sec-butyl propenyl disulfide (20%), β-pinene (11%), transdihydroagarofuran (6%), allo-aromadendrene (5%), (Z)β-ocimene (4.5%) and α-caryophyllene (3%).…”
Section: Cytotoxic Activitymentioning
confidence: 99%
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“…Sheny et al suggested that terpenoids, including spathulenol, globulol, muurolol, and cadinol, can utilise their tertiary hydroxyl groups to reduce gold ions in the presence of acetone at a high temperature and the oxidised terpenoids attach around the gold nanoparticles through the carboxylate ions, although further investigations are needed to elucidate the exact mechanism [118]. Gold reduction by plant VOCs originated from Artemisia vulgaris and Ferula persica has been achieved after incubation at ambient temperatures for 24 h [119,120]. Green synthesis of silver nanoparticles using plant VOCs has also been reported in several studies using plant VOCs as reducing agents [121,122].…”
Section: Nanoencapsulation Systems For Carrying Plant Volatile Organimentioning
confidence: 99%